Clomipramine
(CMP)
Phase I: N-desmethyl-CMP,
N,
N-didesmethyl-CMP, CMP-N-oxide,
2-OH-CMP, 8-OH-CMP, 10-OH-CMP,
8-OH-N-desmethyl-CMP
Phase II: 2-OH-CMP-Gluc,
8-OH-CMP-Gluc, 2-OH-N-desmethylCMP-Gluc
Phase I: OH-CLP (unidentified position
of OH), N-desmethyl-CMP,
OH-Ndesmethyl-CLP (unidentified position of
OH)
Lepidium sativum
[34]
Diazepam
(DZP)
Phase I: N-desmethyl-DZP
(nordazepam), OH-DZP
(temazepam),
N-desmethyl-OH-DZP
(oxazepam)
Phase I: N-desmethyl-DZP
(nordazepam), OH-DZP
(temazepam),
N-desmethyl-OH-DZP
(oxazepam)
Raphanus sativus, Beta vulgaris,
Cucumis sativus
[35, 36]
Diclofenac
(DCF)
Phase I: 4-OH-DCF,
3
0
-OH-DCF, 4
0
,5diOH-DCF
Phase II: DCF-AGluc, 30
-OH-4
0
methoxy-DCF, 30
-OH-DCF-Sulf, 4-OH-DCF-Sulf,
3
0
-OH-DCF-Gluc, 4-OH-DCF-Gluc
Phase I: 4-OH-DCF
Phase II: 4-OH-DCF-Hex, DCF-HexMal, OH-DCF-Hex-Mal, DCF-Gln,
DCF-Glu, 4-OH-DCF-GSH
Hordeum vulgare,
hairy root cell culture of Armoracia rusticana,
Cucumber
and radish (horse radish), Typha
latifolia
[37–40]
Ibuprofen (IBU) Phase I: 1-OH-IBU, 2-OH-IBU,
3-OH-IBU, carboxy-IBU
Phase II: IBU-AGluc
Phase I: OH-IBU (unidentified position
of OH), 1-OH-IBU, 2-OH-IBU, diOHIBU, carboxy-IBU
Phase II: IBU-Glu, OH-IBU-Gluc,
IBU-Hex, IBU-Hex-Hex, OH-IBU-Hex,
OH-IBU-Glu, IBU-Glu, OH-IBU-Glu,
OH-IBU-Ser, acetyl-IBU-Hex,
OH-acetyl-IBU-Hex, IBU-Hex-Mal,
IBU-DeOHex-Hex, acetyl-IBUDeOHex-Hex
Phragmites australis, Vigna
unguiculata L. Walp, Arabidopsis
thaliana
(cells), Typha angustifolia,
Lemna gibba
[41–47]
Iopromide
(IOP)
Not metabolized
Phase I: Dehydro-IOP, di-dehydro-IOP,
IOP-carboxylic acid, dehydro-IOP-carboxylic acid, IOP-dicarboxylic acid,
dehydro-IOP-dicarboxylic acid,
de-carboxy-didehydro-IOP-carboxylic
acid, di-iodo-IOP
Typha latifolia
[48]
(continued)
Metabolism of Pharmaceuticals in Plants and Their Associated Microbiota
235