11. Pico Y, Alvarez-Ruiz R, Alfarhan AH, El-Sheikh MA, Alobaid SM, Barcelo D (2019) Uptake
and accumulation of emerging contaminants in soil and plant treated with wastewater under
real-world environmental conditions in the Al Hayer area (Saudi Arabia). Sci Total Environ
652:562–572
12. Dolliver H, Kumar K, Gupta S (2007) Sulfamethazine uptake by plants from manure-amended
soil. J Environ Qual 36:1224–1230
13. Wu C, Spongberg AL, Witter JD, Fang M, Czajkowski KP (2010) Uptake of pharmaceutical
and personal care products by soybean plants from soils applied with biosolids and irrigated
with contaminated water. Environ Sci Technol 44:6157–6161
14. de Santiago-Martín A, Meffe R, Teijón G, Martínez Hernández V, López-Heras I, Alonso
Alonso C, Arenas Romasanta M, de Bustamante I (2020) Pharmaceuticals and trace metals in
the surface water used for crop irrigation: risk to health or natural attenuation? Sci Total
Environ 705:135825
15. Martínez-Piernas AB, Polo-López MI, Fernández-Ibáñez P, Agüera A (2018) Validation and
application of a multiresidue method based on liquid chromatography-tandem mass spectrometry for evaluating the plant uptake of 74 microcontaminants in crops irrigated with treated
municipal wastewater. J Chromatogr A 1534:10–21
16. Beltrán EM, Pablos MV, Fernández Torija C, Porcel MÁ, González-Doncel M (2020) Uptake
of atenolol, carbamazepine and triclosan by crops irrigated with reclaimed water in a Mediterranean scenario. Ecotoxicol Environ Saf 191:110171
17. Jones-Lepp TL, Sanchez CA, Moy T, Kazemi R (2010) Method development and application
to determine potential plant uptake of antibiotics and other drugs in irrigated crop production
systems. J Agric Food Chem 58(22):11568–11573
18. Martínez-Piernas AB, Plaza-Bolaños P, Fernández-Ibáñez P, Agüera A (2019) Organic
microcontaminants in tomato crops irrigated with reclaimed water grown under field conditions: occurrence, uptake, and health risk assessment. J Agric Food Chem 67(25):6930–6939
19. Riemenschneider C, Al-Raggad M, Moeder M, Seiwert B, Salameh E, Reemtsma T (2016)
Pharmaceuticals, their metabolites, and other polar pollutants in field-grown vegetables irrigated with treated municipal wastewater. J Agric Food Chem 64(29):5784–5792
20. Malchi T, Maor Y, Tadmor G, Shenker M, Chefetz B (2014) Irrigation of root vegetables with
treated wastewater: evaluating uptake of pharmaceuticals and the associated human health
risks. Environ Sci Technol 48(16):9325–9333
21. Franklin AM, Williams CF, Andrews DM, Woodward EE, Watson JE (2016) Uptake of three
antibiotics and an antiepileptic drug by wheat crops spray irrigated with wastewater treatment
plant effluent. J Environ Qual 45(2):546–554
22. Calderón-Preciado D, Matamoros V, Savé R, Muñoz P, Biel C, Bayona JM (2013) Uptake of
microcontaminants by crops irrigated with reclaimed water and groundwater under real field
greenhouse conditions. Environ Sci Pollut Res 20(6):3629–3638
23. Shenker M, Harush D, Ben-Ari J, Chefetz B (2011) Uptake of carbamazepine by cucumber
plants – a case study related to irrigation with reclaimed wastewater. Chemosphere
82:905–910
24. Christou A, Karaolia P, Hapeshi E, Michael C, Fatta-Kassinos D (2017) Long-term wastewater irrigation of vegetables in real agricultural systems: concentration of pharmaceuticals in
soil, uptake and bioaccumulation in tomato fruits and human health risk assessment. Water
Res 109:24–34
25. Sabourin L, Duenk P, Bonte-Gelok S, Payne M, Lapen DR, Topp E (2012) Uptake of
pharmaceuticals, hormones and parabens into vegetables grown in soil fertilized with municipal biosolids. Sci Total Environ 431:233–236
26. Cantarero R, Richter P, Brown S, Ascar L, Ahumada I (2017) Effects of applying biosolids to
soils on the adsorption and bioavailability of 17α-ethinylestradiol and triclosan in wheat
plants. Environ Sci Pollut Res 24:12847–12859
Uptake and Effects of Pharmaceuticals in the Soil-Plant-Earthworm System
213
and accumulation of emerging contaminants in soil and plant treated with wastewater under
real-world environmental conditions in the Al Hayer area (Saudi Arabia). Sci Total Environ
652:562–572
12. Dolliver H, Kumar K, Gupta S (2007) Sulfamethazine uptake by plants from manure-amended
soil. J Environ Qual 36:1224–1230
13. Wu C, Spongberg AL, Witter JD, Fang M, Czajkowski KP (2010) Uptake of pharmaceutical
and personal care products by soybean plants from soils applied with biosolids and irrigated
with contaminated water. Environ Sci Technol 44:6157–6161
14. de Santiago-Martín A, Meffe R, Teijón G, Martínez Hernández V, López-Heras I, Alonso
Alonso C, Arenas Romasanta M, de Bustamante I (2020) Pharmaceuticals and trace metals in
the surface water used for crop irrigation: risk to health or natural attenuation? Sci Total
Environ 705:135825
15. Martínez-Piernas AB, Polo-López MI, Fernández-Ibáñez P, Agüera A (2018) Validation and
application of a multiresidue method based on liquid chromatography-tandem mass spectrometry for evaluating the plant uptake of 74 microcontaminants in crops irrigated with treated
municipal wastewater. J Chromatogr A 1534:10–21
16. Beltrán EM, Pablos MV, Fernández Torija C, Porcel MÁ, González-Doncel M (2020) Uptake
of atenolol, carbamazepine and triclosan by crops irrigated with reclaimed water in a Mediterranean scenario. Ecotoxicol Environ Saf 191:110171
17. Jones-Lepp TL, Sanchez CA, Moy T, Kazemi R (2010) Method development and application
to determine potential plant uptake of antibiotics and other drugs in irrigated crop production
systems. J Agric Food Chem 58(22):11568–11573
18. Martínez-Piernas AB, Plaza-Bolaños P, Fernández-Ibáñez P, Agüera A (2019) Organic
microcontaminants in tomato crops irrigated with reclaimed water grown under field conditions: occurrence, uptake, and health risk assessment. J Agric Food Chem 67(25):6930–6939
19. Riemenschneider C, Al-Raggad M, Moeder M, Seiwert B, Salameh E, Reemtsma T (2016)
Pharmaceuticals, their metabolites, and other polar pollutants in field-grown vegetables irrigated with treated municipal wastewater. J Agric Food Chem 64(29):5784–5792
20. Malchi T, Maor Y, Tadmor G, Shenker M, Chefetz B (2014) Irrigation of root vegetables with
treated wastewater: evaluating uptake of pharmaceuticals and the associated human health
risks. Environ Sci Technol 48(16):9325–9333
21. Franklin AM, Williams CF, Andrews DM, Woodward EE, Watson JE (2016) Uptake of three
antibiotics and an antiepileptic drug by wheat crops spray irrigated with wastewater treatment
plant effluent. J Environ Qual 45(2):546–554
22. Calderón-Preciado D, Matamoros V, Savé R, Muñoz P, Biel C, Bayona JM (2013) Uptake of
microcontaminants by crops irrigated with reclaimed water and groundwater under real field
greenhouse conditions. Environ Sci Pollut Res 20(6):3629–3638
23. Shenker M, Harush D, Ben-Ari J, Chefetz B (2011) Uptake of carbamazepine by cucumber
plants – a case study related to irrigation with reclaimed wastewater. Chemosphere
82:905–910
24. Christou A, Karaolia P, Hapeshi E, Michael C, Fatta-Kassinos D (2017) Long-term wastewater irrigation of vegetables in real agricultural systems: concentration of pharmaceuticals in
soil, uptake and bioaccumulation in tomato fruits and human health risk assessment. Water
Res 109:24–34
25. Sabourin L, Duenk P, Bonte-Gelok S, Payne M, Lapen DR, Topp E (2012) Uptake of
pharmaceuticals, hormones and parabens into vegetables grown in soil fertilized with municipal biosolids. Sci Total Environ 431:233–236
26. Cantarero R, Richter P, Brown S, Ascar L, Ahumada I (2017) Effects of applying biosolids to
soils on the adsorption and bioavailability of 17α-ethinylestradiol and triclosan in wheat
plants. Environ Sci Pollut Res 24:12847–12859
Uptake and Effects of Pharmaceuticals in the Soil-Plant-Earthworm System
213