12. Papaioannou D, Koukoulakis PH, Lambropoulou D, Papageorgiou M, Kalavrouziotis IK
(2019) The dynamics of the pharmaceutical and personal care product interactive capacity
under the effect of artificial enrichment of soil with heavy metals and of wastewater reuse. Sci
Total Environ 662:537–546. https://doi.org/10.1016/j.scitotenv.2019.01.111
13. Barra Caracciolo A, Topp E, Grenni P (2015) Pharmaceuticals in the environment: biodegradation and effects on natural microbial communities. A review. J Pharm Biomed Anal
106:25–36. https://doi.org/10.1016/j.jpba.2014.11.040
14. Afzal M, Khan QM, Sessitsch A (2014) Endophytic bacteria: prospects and applications for
the phytoremediation of organic pollutants. Chemosphere 117:232–242. https://doi.org/10.
1016/j.chemosphere.2014.06.078
15. Sauvêtre A, Schröder P (2015) Uptake of carbamazepine by rhizomes and endophytic bacteria
of Phragmites australis. Front Plant Sci 6:83. https://doi.org/10.3389/fpls.2015.00083
16. Weyens N, van der Lelie D, Taghavi S, Vangronsveld J (2009) Phytoremediation: plantendophyte partnerships take the challenge. Curr Opin Biotechnol 20:248–254. https://doi.org/
10.1016/j.copbio.2009.02.012
17. Agrawal N, Shahi SK (2015) An environmental cleanup strategy-microbial transformation of
xenobiotic compounds. Int J Curr Microbiol App Sci 4:429–461
18. Miransari M (2013) Soil microbes and the availability of soil nutrients. Acta Physiol Plant
35:3075–3084. https://doi.org/10.1007/s11738-013-1338-2
19. Diekmann F, Nepovim A, Schröder P (2004) Influence of Serratia liquifaciens and a xenobiotic glutathione conjugate on the detoxification enzymes in a hairy root culture of horseradish
(Armoracia rusticana). J Appl Bot 78:64–67
20. Chuang YH, Liu CH, Sallach JB, Hammerschmidt R, Zhang W, Boyd SA, Li H (2019)
Mechanistic study on uptake and transport of pharmaceuticals in lettuce from water. Environ
Int 131:104976. https://doi.org/10.1016/j.envint.2019.104976
21. Kvesitadze G, Khatisashvili G, Sadunishvili T, Kvesitadze E (2016) Plants for remediation:
uptake, translocation and transformation of organic pollutants. In: Plants, pollutants and
remediation. Springer, Dordrecht, pp 241–308. https://doi.org/10.1007/978-94-017-7194-8_
12
22. Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K,
Staveley JP, Verslycke T, Ankley GT, Beazley KF, Belanger SE, Berninger JP,
Carriquiriborde P, Coors A, DeLeo PC, Dyer SD, Ericson JF, Gagné F, Giesy JP, Gouin T,
Hallstrom L, Karlsson MV, Joakim Larsson DG, Lazorchak JM, Mastrocco F, McLaughlin A,
McMaster ME, Meyerhoff RD, Moore R, Parrott JL, Snape JR, Murray-Smith R, Servos MR,
Sibley PK, Straub JO, Szabo ND, Topp E, Tetreault GR, Trudeau VL, Van Der Kraak G
(2012) Pharmaceuticals and personal care products in the environment: what are the big
questions? Environ Health Perspect 120:1221–1229. https://doi.org/10.1289/ehp.1104477
23. Kah M, Brown CD (2008) Log D: lipophilicity for ionisable compounds. Chemosphere
72:1401–1408. https://doi.org/10.1016/j.chemosphere.2008.04.074
24. Xing L, Glen RC (2002) Novel methods for the prediction of logP, Pka, and logD. J Chem Inf
Comput Sci 42:796–805. https://doi.org/10.1021/ci010315d
25. Briggs GG, Bromilow RH, Evans AA, Williams M (1983) Relationships between lipophilicity
and the distribution of non-ionised chemicals in barley shoots following uptake by the roots.
Pestic Sci 14:492–500. https://doi.org/10.1002/ps.2780140506
26. Schröder P, Collins C (2002) Conjugating enzymes involved in xenobiotic metabolism of
organic xenobiotics in plants. Int J Phytoremediation 4:247–265. https://doi.org/10.1080/
15226510208500086
27. Wild E, Dent J, Thomas GO, Jones KC (2005) Direct observation of organic contaminant
uptake, storage, and metabolism within plant roots. Environ Sci Technol 39:3695–3702.
https://doi.org/10.1021/es048136a
28. Cousins IT, Mackay D (2001) Strategies for including vegetation compartments in multimedia
models. Chemosphere 44:643–654. https://doi.org/10.1016/S0045-6535(00)00514-2
Uptake and Translocation of Pharmaceuticals in Plants:. . .
133
(2019) The dynamics of the pharmaceutical and personal care product interactive capacity
under the effect of artificial enrichment of soil with heavy metals and of wastewater reuse. Sci
Total Environ 662:537–546. https://doi.org/10.1016/j.scitotenv.2019.01.111
13. Barra Caracciolo A, Topp E, Grenni P (2015) Pharmaceuticals in the environment: biodegradation and effects on natural microbial communities. A review. J Pharm Biomed Anal
106:25–36. https://doi.org/10.1016/j.jpba.2014.11.040
14. Afzal M, Khan QM, Sessitsch A (2014) Endophytic bacteria: prospects and applications for
the phytoremediation of organic pollutants. Chemosphere 117:232–242. https://doi.org/10.
1016/j.chemosphere.2014.06.078
15. Sauvêtre A, Schröder P (2015) Uptake of carbamazepine by rhizomes and endophytic bacteria
of Phragmites australis. Front Plant Sci 6:83. https://doi.org/10.3389/fpls.2015.00083
16. Weyens N, van der Lelie D, Taghavi S, Vangronsveld J (2009) Phytoremediation: plantendophyte partnerships take the challenge. Curr Opin Biotechnol 20:248–254. https://doi.org/
10.1016/j.copbio.2009.02.012
17. Agrawal N, Shahi SK (2015) An environmental cleanup strategy-microbial transformation of
xenobiotic compounds. Int J Curr Microbiol App Sci 4:429–461
18. Miransari M (2013) Soil microbes and the availability of soil nutrients. Acta Physiol Plant
35:3075–3084. https://doi.org/10.1007/s11738-013-1338-2
19. Diekmann F, Nepovim A, Schröder P (2004) Influence of Serratia liquifaciens and a xenobiotic glutathione conjugate on the detoxification enzymes in a hairy root culture of horseradish
(Armoracia rusticana). J Appl Bot 78:64–67
20. Chuang YH, Liu CH, Sallach JB, Hammerschmidt R, Zhang W, Boyd SA, Li H (2019)
Mechanistic study on uptake and transport of pharmaceuticals in lettuce from water. Environ
Int 131:104976. https://doi.org/10.1016/j.envint.2019.104976
21. Kvesitadze G, Khatisashvili G, Sadunishvili T, Kvesitadze E (2016) Plants for remediation:
uptake, translocation and transformation of organic pollutants. In: Plants, pollutants and
remediation. Springer, Dordrecht, pp 241–308. https://doi.org/10.1007/978-94-017-7194-8_
12
22. Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K,
Staveley JP, Verslycke T, Ankley GT, Beazley KF, Belanger SE, Berninger JP,
Carriquiriborde P, Coors A, DeLeo PC, Dyer SD, Ericson JF, Gagné F, Giesy JP, Gouin T,
Hallstrom L, Karlsson MV, Joakim Larsson DG, Lazorchak JM, Mastrocco F, McLaughlin A,
McMaster ME, Meyerhoff RD, Moore R, Parrott JL, Snape JR, Murray-Smith R, Servos MR,
Sibley PK, Straub JO, Szabo ND, Topp E, Tetreault GR, Trudeau VL, Van Der Kraak G
(2012) Pharmaceuticals and personal care products in the environment: what are the big
questions? Environ Health Perspect 120:1221–1229. https://doi.org/10.1289/ehp.1104477
23. Kah M, Brown CD (2008) Log D: lipophilicity for ionisable compounds. Chemosphere
72:1401–1408. https://doi.org/10.1016/j.chemosphere.2008.04.074
24. Xing L, Glen RC (2002) Novel methods for the prediction of logP, Pka, and logD. J Chem Inf
Comput Sci 42:796–805. https://doi.org/10.1021/ci010315d
25. Briggs GG, Bromilow RH, Evans AA, Williams M (1983) Relationships between lipophilicity
and the distribution of non-ionised chemicals in barley shoots following uptake by the roots.
Pestic Sci 14:492–500. https://doi.org/10.1002/ps.2780140506
26. Schröder P, Collins C (2002) Conjugating enzymes involved in xenobiotic metabolism of
organic xenobiotics in plants. Int J Phytoremediation 4:247–265. https://doi.org/10.1080/
15226510208500086
27. Wild E, Dent J, Thomas GO, Jones KC (2005) Direct observation of organic contaminant
uptake, storage, and metabolism within plant roots. Environ Sci Technol 39:3695–3702.
https://doi.org/10.1021/es048136a
28. Cousins IT, Mackay D (2001) Strategies for including vegetation compartments in multimedia
models. Chemosphere 44:643–654. https://doi.org/10.1016/S0045-6535(00)00514-2
Uptake and Translocation of Pharmaceuticals in Plants:. . .
133