of ATP-sensitive K+ channels. The
Journal of Physiology. 2000;529:723-734
[37] Furuta A, Martin LJ, Lin CL, DykesHoberg M, Rothstein JD. Cellular and
synaptic localization of the neuronal
glutamate transporters excitatory amino
acid transporter 3 and 4. Neuroscience.
1997;81:1031-1042
[38] Dehnes Y, Chaudhry FA,
Ullensvang K, Lehre KP, StormMathisen J, Danbolt NC. The glutamate
transporter EAAT4 in rat cerebellar
Purkinje cells: A glutamate-gated
chloride channel concentrated near the
synapse in parts of the dendritic
membrane facing astroglia. The Journal
of Neuroscience. 1998;18:3606-3619
[39] Mitrovic AD, Plesko F, Vanenberg
RJ. Zn
2+ inhibits the anion conductance
of the glutamate transporter EAAT4.
The Journal of Biological Chemistry.
2001;276:26071-26076
[40] Jones O, Bernstein G, Jones E,
Jugloff D, Law M, et al. N-type calcium
channels in the developing rat
hippocampus: Subunit, complex, and
regional expression. The Journal of
Neuroscience. 1997;17:6152-6164
[41] Büsselberg D, Michael D, Evans M,
Carpenter O, Haas H. Zinc (Zn
2+ ) blocks
voltage gated calcium channels in
cultured rat dorsal root ganglion cells.
Brain Research. 1992;593:77-81
[42] Hell J, Westenbroek R, Warner C,
Ahlijanian M, Prystay W, et al.
Identification and differential
subcellular localization of the neuronal
class C and class D L-type calcium
channel α subunits. The Journal of Cell
Biology. 1993;123:949-962
[43] Frederickson CJ, Suh SW, Silva D,
Frederickson CJ, Thomson RB.
Importance of zinc in the central
nervous system: The zinc-containing
neuron. The Journal of Nutrition. 2000;
130:1471-1478
[44] Colvin RA, Fontaine CP, Laskowski
M, Thomas D. Zn
2+ transporters and Zn
2+
homeostasis in neurons. European
Journal of Pharmacology. 2003;479:
171-185
[45] Colvin R, Bush A, Volitakis I,
Fontaine C, Thomas D, Kikuchi K, et al.
Insights into Zn
2+ homeostasis in
neurons from experimental and
modeling studies. American Journal of
Physiology. Cell Physiology. 2008;294:
726-742
[46] Huang L, Tepaamorndech S. The
SLC30 family of zinc transporters—A
review of current understanding of their
biological and pathophysiological roles.
Molecular Aspects of Medicine. 2013;34:
548-560
[47] Sensi S, Paoletti P, Koh J, Aizenman
E, Bush A, Hershfinkel M. The
neurophysiology and pathology of brain
zinc. The Journal of Neuroscience. 2011;
31:16076-16085
[48] Ueno S, Tsukamoto M, Hirano T,
Kikuchi K, Yamada M, et al. Mossy fiber
Zn
2+ spillover modulates heterosynaptic
N-methyl-d-aspartate receptor activity
in hippocampal CA3 circuits. The
Journal of Cell Biology. 2002;158:
215-220
[49] Bourne JN, Harris KM. Dendritic
spines. eLS. 2007. DOI: 10.1002/
9780470015902.a0000093.pub2
[50] Savtchenko LP, Rusakov DA. The
optimal height of the synaptic cleft.
Proceedings of the National Academy of
Sciences of the United States of
America. 2008;104:1823-1828
[51] Rollenhagen A, Lübke JHR. The
mossy fiber Bouton: The “common” or
the “unique” synapse? Frontiers in
Synaptic Neuroscience. 2010;2:2. DOI:
10.3389/fnsyn.2010.00002
[52] Chicurel ME, Harris KM. Threedimensional analysis of the structure
128
Advances in Neural Signal Processing
Journal of Physiology. 2000;529:723-734
[37] Furuta A, Martin LJ, Lin CL, DykesHoberg M, Rothstein JD. Cellular and
synaptic localization of the neuronal
glutamate transporters excitatory amino
acid transporter 3 and 4. Neuroscience.
1997;81:1031-1042
[38] Dehnes Y, Chaudhry FA,
Ullensvang K, Lehre KP, StormMathisen J, Danbolt NC. The glutamate
transporter EAAT4 in rat cerebellar
Purkinje cells: A glutamate-gated
chloride channel concentrated near the
synapse in parts of the dendritic
membrane facing astroglia. The Journal
of Neuroscience. 1998;18:3606-3619
[39] Mitrovic AD, Plesko F, Vanenberg
RJ. Zn
2+ inhibits the anion conductance
of the glutamate transporter EAAT4.
The Journal of Biological Chemistry.
2001;276:26071-26076
[40] Jones O, Bernstein G, Jones E,
Jugloff D, Law M, et al. N-type calcium
channels in the developing rat
hippocampus: Subunit, complex, and
regional expression. The Journal of
Neuroscience. 1997;17:6152-6164
[41] Büsselberg D, Michael D, Evans M,
Carpenter O, Haas H. Zinc (Zn
2+ ) blocks
voltage gated calcium channels in
cultured rat dorsal root ganglion cells.
Brain Research. 1992;593:77-81
[42] Hell J, Westenbroek R, Warner C,
Ahlijanian M, Prystay W, et al.
Identification and differential
subcellular localization of the neuronal
class C and class D L-type calcium
channel α subunits. The Journal of Cell
Biology. 1993;123:949-962
[43] Frederickson CJ, Suh SW, Silva D,
Frederickson CJ, Thomson RB.
Importance of zinc in the central
nervous system: The zinc-containing
neuron. The Journal of Nutrition. 2000;
130:1471-1478
[44] Colvin RA, Fontaine CP, Laskowski
M, Thomas D. Zn
2+ transporters and Zn
2+
homeostasis in neurons. European
Journal of Pharmacology. 2003;479:
171-185
[45] Colvin R, Bush A, Volitakis I,
Fontaine C, Thomas D, Kikuchi K, et al.
Insights into Zn
2+ homeostasis in
neurons from experimental and
modeling studies. American Journal of
Physiology. Cell Physiology. 2008;294:
726-742
[46] Huang L, Tepaamorndech S. The
SLC30 family of zinc transporters—A
review of current understanding of their
biological and pathophysiological roles.
Molecular Aspects of Medicine. 2013;34:
548-560
[47] Sensi S, Paoletti P, Koh J, Aizenman
E, Bush A, Hershfinkel M. The
neurophysiology and pathology of brain
zinc. The Journal of Neuroscience. 2011;
31:16076-16085
[48] Ueno S, Tsukamoto M, Hirano T,
Kikuchi K, Yamada M, et al. Mossy fiber
Zn
2+ spillover modulates heterosynaptic
N-methyl-d-aspartate receptor activity
in hippocampal CA3 circuits. The
Journal of Cell Biology. 2002;158:
215-220
[49] Bourne JN, Harris KM. Dendritic
spines. eLS. 2007. DOI: 10.1002/
9780470015902.a0000093.pub2
[50] Savtchenko LP, Rusakov DA. The
optimal height of the synaptic cleft.
Proceedings of the National Academy of
Sciences of the United States of
America. 2008;104:1823-1828
[51] Rollenhagen A, Lübke JHR. The
mossy fiber Bouton: The “common” or
the “unique” synapse? Frontiers in
Synaptic Neuroscience. 2010;2:2. DOI:
10.3389/fnsyn.2010.00002
[52] Chicurel ME, Harris KM. Threedimensional analysis of the structure
128
Advances in Neural Signal Processing