and composition of CA3 branched
dendritic spines and their synaptic
relationships with mossy fiber boutons
in the rat hippocampus. The Journal of
Comparative Neurology. 1992;325:
169-182
[53] Press WH, Teukolsky SA, Vetterling
WT, Flannery BP. Numerical Recipes in
Fortran. The Art of Scientific
Computing. 2nd ed. Cambridge:
Cambridge University Press; 1992
[54] Melani A, Turchi A, Vannucchi M,
Cipriani C, Gianfriddo M, et al. ATP
extracellular concentrations are
increased in the rat striatum during in
vivo ischemia. Neurochemistry
International. 2005;47:442-448
[55] Jiang L, Maret W, Vallee B. The
glutathione redox couple modulates zinc
transfer from metallothionein to zincdepleted sorbitol dehydrogenase.
Proceedings of the National Academy of
Sciences of the United States of
America. 1998;95:3483-3488
[56] Kay A. Evidence for chelatable zinc
in the extracellular space of the
hippocampus, but little evidence for
synaptic release of Zn. The Journal of
Neuroscience. 2003;23:6847-6855
[57] Fraústo da Silva JJR, Williams RJP.
The Biological Chemistry of the
Elements. The Inorganic Chemistry of
Life. New York: Oxford University
Press; 1991
[58] Conti R, LIsman J. The high
variance of AMPA receptor- and NMDA
receptor-mediated responses at single
hippocampal synapses: Evidence for
multiquantal release. Proceedings of the
National Academy of Sciences of the
United States of America. 2003;100:
4885-4890
[59] Bischofberger J, Engel D, Frotscher
M, Jonas P. Timing and efficacy of
transmitter release at mossy fiber
synapses in the hippocampal network.
European Journal of Physiology. 2006.
DOI: 10.1007/s00424-006-0093-2
[60] Hallermann S, Pawlu C, Jonas P,
Heckmann M. A large pool of releasable
vesicles in a cortical glutamatergic
synapse. Proceedings of the National
Academy of Sciences of the United
States of America. 2003;100:8975-8980
[61] Wenzel H, Cole T, Born D,
Schwartzkroin P. Ultrastructural
localization of zinc transporter-3 (ZnT3) to synaptic vesicle membranes within
mossy fiber boutons in the hippocampus
of mouse and monkey. Proceedings of
the National Academy of Sciences of the
United States of America. 1997;94:
12676-12681
[62] Rollenhagen A, Sätzler K, Rodríguez
EP, Jonas P, Frotscher M, Lübke JH.
Structural determinants of transmission
at large hippocampal mossy fiber
synapses. The Journal of Neuroscience.
2007;27:10434-10444
[63] Savtchenko LP, Rusakov DA.
Glutamate escape from a tortuous
synaptic cleft of the hippocampal mossy
fibre synapse. Neurochemistry
International. 2004;45:479-484
[64] Harris KM, Sultan P. Variation in
number, location and size of synaptic
vesicles provides an anatomical basis
for the nonuniform probability of
release at hippocampal CA1 synapses.
Neuropharmacology. 1995;34:1387-1395
[65] Kessler JP. Control of cleft
glutamate concentration and glutamate
spill-out by perisynaptic glia: Uptake
and diffusion barriers. PLoS One. 2013;
8(8):e70791
[66] Hires S, Zhu Y, Tsien R. Optical
measurement of synaptic glutamate
spillover and reuptake by linker
optimized glutamate-sensitive
fluorescent reporters. Proceedings of the
National Academy of Sciences of the
United States of America. 2008;105:
4411-4416
129
Computer Simulations of Hippocampal Mossy Fiber Cleft Zinc Movements
DOI: http://dx.doi.org/10.5772/intechopen.90094
dendritic spines and their synaptic
relationships with mossy fiber boutons
in the rat hippocampus. The Journal of
Comparative Neurology. 1992;325:
169-182
[53] Press WH, Teukolsky SA, Vetterling
WT, Flannery BP. Numerical Recipes in
Fortran. The Art of Scientific
Computing. 2nd ed. Cambridge:
Cambridge University Press; 1992
[54] Melani A, Turchi A, Vannucchi M,
Cipriani C, Gianfriddo M, et al. ATP
extracellular concentrations are
increased in the rat striatum during in
vivo ischemia. Neurochemistry
International. 2005;47:442-448
[55] Jiang L, Maret W, Vallee B. The
glutathione redox couple modulates zinc
transfer from metallothionein to zincdepleted sorbitol dehydrogenase.
Proceedings of the National Academy of
Sciences of the United States of
America. 1998;95:3483-3488
[56] Kay A. Evidence for chelatable zinc
in the extracellular space of the
hippocampus, but little evidence for
synaptic release of Zn. The Journal of
Neuroscience. 2003;23:6847-6855
[57] Fraústo da Silva JJR, Williams RJP.
The Biological Chemistry of the
Elements. The Inorganic Chemistry of
Life. New York: Oxford University
Press; 1991
[58] Conti R, LIsman J. The high
variance of AMPA receptor- and NMDA
receptor-mediated responses at single
hippocampal synapses: Evidence for
multiquantal release. Proceedings of the
National Academy of Sciences of the
United States of America. 2003;100:
4885-4890
[59] Bischofberger J, Engel D, Frotscher
M, Jonas P. Timing and efficacy of
transmitter release at mossy fiber
synapses in the hippocampal network.
European Journal of Physiology. 2006.
DOI: 10.1007/s00424-006-0093-2
[60] Hallermann S, Pawlu C, Jonas P,
Heckmann M. A large pool of releasable
vesicles in a cortical glutamatergic
synapse. Proceedings of the National
Academy of Sciences of the United
States of America. 2003;100:8975-8980
[61] Wenzel H, Cole T, Born D,
Schwartzkroin P. Ultrastructural
localization of zinc transporter-3 (ZnT3) to synaptic vesicle membranes within
mossy fiber boutons in the hippocampus
of mouse and monkey. Proceedings of
the National Academy of Sciences of the
United States of America. 1997;94:
12676-12681
[62] Rollenhagen A, Sätzler K, Rodríguez
EP, Jonas P, Frotscher M, Lübke JH.
Structural determinants of transmission
at large hippocampal mossy fiber
synapses. The Journal of Neuroscience.
2007;27:10434-10444
[63] Savtchenko LP, Rusakov DA.
Glutamate escape from a tortuous
synaptic cleft of the hippocampal mossy
fibre synapse. Neurochemistry
International. 2004;45:479-484
[64] Harris KM, Sultan P. Variation in
number, location and size of synaptic
vesicles provides an anatomical basis
for the nonuniform probability of
release at hippocampal CA1 synapses.
Neuropharmacology. 1995;34:1387-1395
[65] Kessler JP. Control of cleft
glutamate concentration and glutamate
spill-out by perisynaptic glia: Uptake
and diffusion barriers. PLoS One. 2013;
8(8):e70791
[66] Hires S, Zhu Y, Tsien R. Optical
measurement of synaptic glutamate
spillover and reuptake by linker
optimized glutamate-sensitive
fluorescent reporters. Proceedings of the
National Academy of Sciences of the
United States of America. 2008;105:
4411-4416
129
Computer Simulations of Hippocampal Mossy Fiber Cleft Zinc Movements
DOI: http://dx.doi.org/10.5772/intechopen.90094