at hippocampal mossy fiber synapses.
Neuron. 2000;26:187-196
[20] Li Y, Hough CJ, Suh SW, Sarvey JM,
Frederickson CJ. Rapid translocation of
Zn
2+ from presynaptic terminals into
postsynaptic hippocampal neurons after
physiological stimulation. Journal of
Neurophysiology. 2001;86:2597-2604
[21] Li Y, Hough CJ, Frederickson CJ,
Sarvey JM. Induction of mossy
fiber!Ca3 long-term potentiation
requires translocation of synaptically
released Zn
2+ . The Journal of
Neuroscience. 2001b;21:8015-8025
[22] Quinta-Ferreira ME, Matias CM,
Arif M, Dionísio JC. Measurement of
presynaptic zinc changes in
hippocampal mossy fibers. Brain
Research. 2004;1026:1-10
[23] Qian J, Noebels JL. Visualization of
transmitter release with zinc
fluorescencedetection at the mouse
hippocampal mossy fibre synapse. The
Journal of Physiology. 2005;566:747-758
[24] Quinta-Ferreira ME, Matias CM.
Tetanically released zinc inhibits
hippocampal mossy fiber calcium, zinc
and postsynaptic responses. Brain
Research. 2005;1047:1-9
[25] Ketterman J, Li Y. Presynaptic
evidence for zinc release at the mossy
fiber synapse of rat hippocampus.
Journal of Neuroscience Research. 2008;
86:422-434
[26] Khan M, Goldsmith CR, Huang Z,
Georgiou J, Luyben TT, Roder JC, et al.
Two-photon imaging of Zn
2+ dynamics
in mossy fiber boutons of adult
hippocampal slices. Proceedings of the
National Academy of Sciences of the
United States of America. 2014;111:
6786-6791
[27] Vergnano A, Rebola N, Savtchenko
L, Pinheiro P, Casado M, Kieffer B, et al.
Zinc dynamics and action at excitatory
synapses. Neuron. 2014;82:1101-1114
[28] Paoletti P, Arscher P, Neyton C.
High-affinity zinc inhibition of NMDA
NR1–NR2A receptors. The Journal of
Neuroscience. 1997;17:5711-5725
[29] Gao X-M, Sakai K, Roberts R, Dean
B, Tamminga C. Ionotropic glutamate
receptors and expression of N-methylD-aspartate receptor subunits in
subregions of human hippocampus:
Effects of schizophrenia. The American
Journal of Psychiatry. 2000;157(7):11411149
[30] Lehre K, Danbolt N. The number of
glutamate transporter subtype
molecules at glutamatergic synapses:
Chemical and stereological
quantification in young adult rat brain.
The Journal of Neuroscience. 1998;18:
8751-8757
[31] Vanenberg R, Mitrovic A, Johnston
G. Molecular basis for differential
inhibition of glutamate transporter
subtypes by zinc ions. Molecular
Pharmacology. 1998;54:189-196
[32] Nusser Z, Lujan R, Laube G, Roberts
JD, Molnar E, Somogyi P. Cell type and
pathway dependence of synaptic AMPA
receptor number and variability in the
hippocampus. Neuron. 1998;21:545-559
[33] Bresink I, Ebert B, Parsons C,
Mutschler E. Zinc changes AMPA
receptor properties: Results of binding
studies and patch clamp recordings.
Neuropharmacology. 1996;35:503-509
[34] Mott D, Beneviste M, Dingledine R.
pH-dependent inhibition of kainite
receptors by zinc. The Journal of
Neuroscience. 2008;13:1659-1671
[35] Zini S, Tremblay Roisin M-P, BenAri Y. Two binding sites for [
3 H]
glibenclamide in the rat brain. Brain
Research. 1991;542:151-154
[36] Bloc A, Cens T, Cruz H, Dunant Y.
Zinc-induced changes in ionic currents
of clonal rat pancreatic-cells: Activation
127
Computer Simulations of Hippocampal Mossy Fiber Cleft Zinc Movements
DOI: http://dx.doi.org/10.5772/intechopen.90094
Neuron. 2000;26:187-196
[20] Li Y, Hough CJ, Suh SW, Sarvey JM,
Frederickson CJ. Rapid translocation of
Zn
2+ from presynaptic terminals into
postsynaptic hippocampal neurons after
physiological stimulation. Journal of
Neurophysiology. 2001;86:2597-2604
[21] Li Y, Hough CJ, Frederickson CJ,
Sarvey JM. Induction of mossy
fiber!Ca3 long-term potentiation
requires translocation of synaptically
released Zn
2+ . The Journal of
Neuroscience. 2001b;21:8015-8025
[22] Quinta-Ferreira ME, Matias CM,
Arif M, Dionísio JC. Measurement of
presynaptic zinc changes in
hippocampal mossy fibers. Brain
Research. 2004;1026:1-10
[23] Qian J, Noebels JL. Visualization of
transmitter release with zinc
fluorescencedetection at the mouse
hippocampal mossy fibre synapse. The
Journal of Physiology. 2005;566:747-758
[24] Quinta-Ferreira ME, Matias CM.
Tetanically released zinc inhibits
hippocampal mossy fiber calcium, zinc
and postsynaptic responses. Brain
Research. 2005;1047:1-9
[25] Ketterman J, Li Y. Presynaptic
evidence for zinc release at the mossy
fiber synapse of rat hippocampus.
Journal of Neuroscience Research. 2008;
86:422-434
[26] Khan M, Goldsmith CR, Huang Z,
Georgiou J, Luyben TT, Roder JC, et al.
Two-photon imaging of Zn
2+ dynamics
in mossy fiber boutons of adult
hippocampal slices. Proceedings of the
National Academy of Sciences of the
United States of America. 2014;111:
6786-6791
[27] Vergnano A, Rebola N, Savtchenko
L, Pinheiro P, Casado M, Kieffer B, et al.
Zinc dynamics and action at excitatory
synapses. Neuron. 2014;82:1101-1114
[28] Paoletti P, Arscher P, Neyton C.
High-affinity zinc inhibition of NMDA
NR1–NR2A receptors. The Journal of
Neuroscience. 1997;17:5711-5725
[29] Gao X-M, Sakai K, Roberts R, Dean
B, Tamminga C. Ionotropic glutamate
receptors and expression of N-methylD-aspartate receptor subunits in
subregions of human hippocampus:
Effects of schizophrenia. The American
Journal of Psychiatry. 2000;157(7):11411149
[30] Lehre K, Danbolt N. The number of
glutamate transporter subtype
molecules at glutamatergic synapses:
Chemical and stereological
quantification in young adult rat brain.
The Journal of Neuroscience. 1998;18:
8751-8757
[31] Vanenberg R, Mitrovic A, Johnston
G. Molecular basis for differential
inhibition of glutamate transporter
subtypes by zinc ions. Molecular
Pharmacology. 1998;54:189-196
[32] Nusser Z, Lujan R, Laube G, Roberts
JD, Molnar E, Somogyi P. Cell type and
pathway dependence of synaptic AMPA
receptor number and variability in the
hippocampus. Neuron. 1998;21:545-559
[33] Bresink I, Ebert B, Parsons C,
Mutschler E. Zinc changes AMPA
receptor properties: Results of binding
studies and patch clamp recordings.
Neuropharmacology. 1996;35:503-509
[34] Mott D, Beneviste M, Dingledine R.
pH-dependent inhibition of kainite
receptors by zinc. The Journal of
Neuroscience. 2008;13:1659-1671
[35] Zini S, Tremblay Roisin M-P, BenAri Y. Two binding sites for [
3 H]
glibenclamide in the rat brain. Brain
Research. 1991;542:151-154
[36] Bloc A, Cens T, Cruz H, Dunant Y.
Zinc-induced changes in ionic currents
of clonal rat pancreatic-cells: Activation
127
Computer Simulations of Hippocampal Mossy Fiber Cleft Zinc Movements
DOI: http://dx.doi.org/10.5772/intechopen.90094