509
metabolites, 252
migration, 254
on neuroendocrine system, 259–260
on obesity, 254, 255
as obesogen and diabetogenic, 258
oxidative potential, 252
peroxisome proliferator-activated
receptors, 252
polycarbonate plastics, 252
receptors, 252
sources, BPA exposure, 253
xenoestrogen substance, 258
Β-cells, pancreatic islets, 258
Blood calcium levels, 13
Blood glucose level, 358
Blood pressure, 434
Body mass index (BMI), 312
Brain development, 90
Brominated FRs (BFRs), 224, 226, 230
antagonistic activity, 232
biotransformation, 230
bromine-decorated aromatic rings, 230
cost-effective and efficient, 233
in vivo, 232
oxidative stress and inflammatory
response, 230
PBDPEs, 228
performance, efficiency and costeffectiveness, 226
thyroid gland in rodents, 231
Brownian NPs, 426
C
Cadmium
and arsenic, 207
catabolic processes, 206
exposure, 206
gluconeogenesis, 208
glucose-6-phosphate dehydrogenase, 207
glycogenolysis, 207
glycolysis, 205
hexokinase and phosphofructokinase, 206
lipid peroxidation, 208
non-occupational sources, 205
pentose phosphate pathway, 207
placenta, 208
pyruvate kinase enzymes, 206
Calcitonin, 11
Carbohydrate metabolism, 44, 394
Carbohydrates, 396, 397
Carbohydrates metabolism
galactosemia, 71
Carcinogenicity, 382
Cardiovascular disease (CVD), 126, 168
Catecholamine, 14
Central diabetes insipidus
primary, 31
secondary, 31
signs and symptoms, 31
Ceramic NPs, 433
Chaperone therapy, 75
C8 Health Project, 313
Chemical messengers, 243
Chemiluminescence assay, 335
Chemko factory, 162
Chick embryo-toxicity test (CHEST), 336
Childhood obesity, 152, 155
long-term consequences, 155
management, 155
measurement, 155
prevention strategies, 156
short-term consequences, 155
Chlorophyllin, 386
Chromaffin ectodermal, 14
Cigarette smoking
caseation, 346
inflammatory response and oxidative
stress, 350
on metabolic pathway, 348
prevalence, 345
SHS, 346 (see also Tobacco smoking)
Coacervation method, 417
Congenital adrenal hyperplasia (CAH), 77
steroidogenesis, 77
Cori’s disease, 50
Corticosterone, 15
Cortisol secretion, 15, 394, 400, 403
Coumestrol, 499
Critical developmental periods, 126
Cryoprotectants, 425
Curcumin, 500
Cushing's syndrome, 28
Cytochrome P450 (CYP450) system, 383
Cytolethality, 192
D
Dendrimers, 432
Depression related medications, 361
Detergents, 344
Diabetes, 34, 35, 453
complications, 35
Diabetes mellitus (DM), 128, 194
definition, 310
Diabetic foot infection (DFI), 128
Diabetic ketoacidosis (DKA), 36
Diabetic pancreas, 88
Index
metabolites, 252
migration, 254
on neuroendocrine system, 259–260
on obesity, 254, 255
as obesogen and diabetogenic, 258
oxidative potential, 252
peroxisome proliferator-activated
receptors, 252
polycarbonate plastics, 252
receptors, 252
sources, BPA exposure, 253
xenoestrogen substance, 258
Β-cells, pancreatic islets, 258
Blood calcium levels, 13
Blood glucose level, 358
Blood pressure, 434
Body mass index (BMI), 312
Brain development, 90
Brominated FRs (BFRs), 224, 226, 230
antagonistic activity, 232
biotransformation, 230
bromine-decorated aromatic rings, 230
cost-effective and efficient, 233
in vivo, 232
oxidative stress and inflammatory
response, 230
PBDPEs, 228
performance, efficiency and costeffectiveness, 226
thyroid gland in rodents, 231
Brownian NPs, 426
C
Cadmium
and arsenic, 207
catabolic processes, 206
exposure, 206
gluconeogenesis, 208
glucose-6-phosphate dehydrogenase, 207
glycogenolysis, 207
glycolysis, 205
hexokinase and phosphofructokinase, 206
lipid peroxidation, 208
non-occupational sources, 205
pentose phosphate pathway, 207
placenta, 208
pyruvate kinase enzymes, 206
Calcitonin, 11
Carbohydrate metabolism, 44, 394
Carbohydrates, 396, 397
Carbohydrates metabolism
galactosemia, 71
Carcinogenicity, 382
Cardiovascular disease (CVD), 126, 168
Catecholamine, 14
Central diabetes insipidus
primary, 31
secondary, 31
signs and symptoms, 31
Ceramic NPs, 433
Chaperone therapy, 75
C8 Health Project, 313
Chemical messengers, 243
Chemiluminescence assay, 335
Chemko factory, 162
Chick embryo-toxicity test (CHEST), 336
Childhood obesity, 152, 155
long-term consequences, 155
management, 155
measurement, 155
prevention strategies, 156
short-term consequences, 155
Chlorophyllin, 386
Chromaffin ectodermal, 14
Cigarette smoking
caseation, 346
inflammatory response and oxidative
stress, 350
on metabolic pathway, 348
prevalence, 345
SHS, 346 (see also Tobacco smoking)
Coacervation method, 417
Congenital adrenal hyperplasia (CAH), 77
steroidogenesis, 77
Cori’s disease, 50
Corticosterone, 15
Cortisol secretion, 15, 394, 400, 403
Coumestrol, 499
Critical developmental periods, 126
Cryoprotectants, 425
Curcumin, 500
Cushing's syndrome, 28
Cytochrome P450 (CYP450) system, 383
Cytolethality, 192
D
Dendrimers, 432
Depression related medications, 361
Detergents, 344
Diabetes, 34, 35, 453
complications, 35
Diabetes mellitus (DM), 128, 194
definition, 310
Diabetic foot infection (DFI), 128
Diabetic ketoacidosis (DKA), 36
Diabetic pancreas, 88
Index