498
Bioactive Compounds Against EDCs Induced Hyperlipidemia
Black mulberry has demonstrate positive results for the treatment of hypercholesterolemia, obesity, and diabetes [82]. Phenolics compounds in black mulberry possess antioxidant property [83–85]. Berberine is a bioactive compound found in
berberries which downregulate genes involved in synthesis of lipids.
Effect of Bioactive Compounds Against EDCs Induced
NAFLD
Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver disorders
ranging from steatosis to non-alcoholic steato-hepatitis (NASH), fibrosis, cirrhosis,
and hepatocellular carcinoma. EDCs have gained special attention for their ability
to impair hepatic function. Plasticizers (bisphenol A), persistent organic pollutants
(dioxins), organotins (tributyltin), organochlorines (dichlorodiphenyltrichloroethane) are examples of some EDCs that might cause NAFLD through peripheral
Table 28.3 Bioactive compounds against EDC’s induced obesity
Sr.
#
Bioactive
compounds
Source
Mechanism of action
Therapeutic
property
1. Fiber
• Citrus fruit
• Oatmeal
• Barley
• Apple
Enhance fat and glucose
metabolism
• Anti- obesity
agent
2. Omega 3 and
Omega 6
• Fish
• Flaxseed
• Soyabeans
• Vegetable oil
• Corn
Reduce plasma triglycerides
• Anti-obesity agent
3. Vitamin C and
Vitamin E
• Citrus fruit
• Almonds
• Peanuts
• Sunflower
Decrease lipid peroxidation
and proinflammatory cytokines
• Anti-obesity agent
• Antiinflammatory
4. Bioactive
peptides
• Egg
• Fish
• Meat
Scavenge free radicals and
reduce cholesterol
• Anti-obesity agent
• Antioxidant
5. Minerals
• Milk
• Green vegetables
• Cashew nuts
Increase lipolysis
• Anti-obesity agent
6. Phytochemicals • Vegetables
• Grains
• Fruit
Prevent accumulation of fats
through burning extra calories
• Anti-obesity agent
7. Probiotics
• Milk
• Yogurt
Inhibition of α-amylase and
pancreatic lipase activity
• Anti-obesity agent
T. H. Mallhi et al.