251
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Switzerland AG 2021
M. S. H. Akash et al. (eds.), Endocrine Disrupting Chemicals-induced
Metabolic Disorders and Treatment Strategies, Emerging Contaminants
and Associated Treatment Technologies,
https://doi.org/10.1007/978-3-030-45923-9_16
Chapter 16
Bisphenol A as an EDC in Metabolic
Disorders
Kanwal Irshad, Kanwal Rehman, Hina Sharif, Muhammad Tariq,
Ghulam Murtaza, Muhammad Ibrahim,
and Muhammad Sajid Hamid Akash
Abstract Bisphenol A (BPA) is a man-made chemical substance that is used in our
daily life for the production of many plastic wares. In this chapter, sources of BPA
exposure and its effects on human being have been summarized in detail. Many
in vivo and in vitro studies show that BPA is considered as a toxic, mutagenic, carcinogenic, and endocrine disruptor. BPA has the ability to disrupt many metabolic
pathways that alter the metabolism of carbohydrates and lipids that may lead to the
development of metabolic disorders. BPA has its role in disturbing the functions of
the liver and alters the production of insulin from β-cells of pancreatic islets. BPA
also interferes with the utilization of glucose in the muscles and in the adipose tissues. It also disrupts the regulation of glucose metabolism in the central nervous
system via the neuroendocrine system that leads to the intolerance of glucose and
insulin which promotes metabolic syndrome. This discussion proves that BPA
exposure is a major risk factor for metabolic diseases.
Keywords Bisphenol A · Metabolic disorder · Adipose tissues · Glucose
metabolism
K. Irshad · H. Sharif · M. S. H. Akash (*)
Department of Pharmaceutical Chemistry, Government College University Faisalabad,
Faisalabad, Pakistan
K. Rehman
Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan
M. Tariq
Department of Pharmacology, Lahore Pharmacy College, Lahore, Pakistan
G. Murtaza
Department of Pharmacy, COMSATS University Islamabad, Lahore, Pakistan
M. Ibrahim
Department of Applied Chemistry, Government College University Faisalabad, Faisalabad,
Pakistan
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Switzerland AG 2021
M. S. H. Akash et al. (eds.), Endocrine Disrupting Chemicals-induced
Metabolic Disorders and Treatment Strategies, Emerging Contaminants
and Associated Treatment Technologies,
https://doi.org/10.1007/978-3-030-45923-9_16
Chapter 16
Bisphenol A as an EDC in Metabolic
Disorders
Kanwal Irshad, Kanwal Rehman, Hina Sharif, Muhammad Tariq,
Ghulam Murtaza, Muhammad Ibrahim,
and Muhammad Sajid Hamid Akash
Abstract Bisphenol A (BPA) is a man-made chemical substance that is used in our
daily life for the production of many plastic wares. In this chapter, sources of BPA
exposure and its effects on human being have been summarized in detail. Many
in vivo and in vitro studies show that BPA is considered as a toxic, mutagenic, carcinogenic, and endocrine disruptor. BPA has the ability to disrupt many metabolic
pathways that alter the metabolism of carbohydrates and lipids that may lead to the
development of metabolic disorders. BPA has its role in disturbing the functions of
the liver and alters the production of insulin from β-cells of pancreatic islets. BPA
also interferes with the utilization of glucose in the muscles and in the adipose tissues. It also disrupts the regulation of glucose metabolism in the central nervous
system via the neuroendocrine system that leads to the intolerance of glucose and
insulin which promotes metabolic syndrome. This discussion proves that BPA
exposure is a major risk factor for metabolic diseases.
Keywords Bisphenol A · Metabolic disorder · Adipose tissues · Glucose
metabolism
K. Irshad · H. Sharif · M. S. H. Akash (*)
Department of Pharmaceutical Chemistry, Government College University Faisalabad,
Faisalabad, Pakistan
K. Rehman
Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan
M. Tariq
Department of Pharmacology, Lahore Pharmacy College, Lahore, Pakistan
G. Murtaza
Department of Pharmacy, COMSATS University Islamabad, Lahore, Pakistan
M. Ibrahim
Department of Applied Chemistry, Government College University Faisalabad, Faisalabad,
Pakistan