171
38. Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, et al. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology. 2010;139(2):653–63.
39. Senft AP, Dalton TP, Nebert DW, Genter MB, Hutchinson RJ, Shertzer HG. Dioxin
increases reactive oxygen production in mouse liver mitochondria. Toxicol Appl Pharmacol.
2002;178(1):15–21.
40. Aly HA, Domènech Ò. Cytotoxicity and mitochondrial dysfunction of 2, 3, 7,
8- tetrachlorodibenzo-p-dioxin (TCDD) in isolated rat hepatocytes. Toxicol Lett.
2009;191(1):79–87.
41. Hwang HJ, Dornbos P, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ. Mitochondrialtargeted aryl hydrocarbon receptor and the impact of 2, 3, 7, 8-tetrachlorodibenzo-pdioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol.
2016;304:121–32.
42. Senft AP, Dalton TP, Nebert DW, Genter MB, Puga A, Hutchinson RJ, et al. Mitochondrial
reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free Radic
Biol Med. 2002;33(9):1268–78.
43. Duval C, Teixeira-Clerc F, Leblanc AF, Touch S, Emond C, Guerre-Millo M, et al. Chronic
exposure to low doses of dioxin promotes liver fibrosis development in the C57BL/6J dietinduced obesity mouse model. Environ Health Perspect. 2016;125(3):428–36.
44. Heindel JJ, Blumberg B, Cave M, Machtinger R, Mantovani A, Mendez MA, et al. Metabolism
disrupting chemicals and metabolic disorders. Reprod Toxicol. 2017;68:3–33.
45. Chamorro-García R, Sahu M, Abbey RJ, Laude J, Pham N, Blumberg B. Transgenerational
inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis
elicited by prenatal exposure to the obesogen tributyltin in mice. Environ Health Perspect.
2013;121(3):359–66.
46. Ghosh S, Murinova L, Trnovec T, Loffredo CA, Washington K, Mitra PS, et al. Biomarkers
linking PCB exposure and obesity. Curr Pharm Biotechnol. 2014;15(11):1058–68.
47. Valvi D, Mendez MA, Martinez D, Grimalt JO, Torrent M, Sunyer J, et al. Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study. Environ Health Perspect. 2011;120(3):451–7.
48. Casas M, Nieuwenhuijsen M, Martínez D, Ballester F, Basagaña X, Basterrechea M, et al.
Prenatal exposure to PCB-153, p, p′-DDE and birth outcomes in 9000 mother–child pairs:
Exposure–response relationship and effect modifiers. Environ Int. 2015;74:23–31.
49. Liu Y, Peterson KE. Maternal exposure to synthetic chemicals and obesity in the offspring:
recent findings. Curr Environ Health Rep. 2015;2(4):339–47.
50. Suarez-Lopez JR, Lee D-H, Porta M, Steffes MW, Jacobs DR Jr. Persistent organic pollutants
in young adults and changes in glucose related metabolism over a 23-year follow-up. Environ
Res. 2015;137:485–94.
51. Beydoun HA, Khanal S, Zonderman AB, Beydoun MA. Sex differences in the association of
urinary bisphenol-A concentration with selected indices of glucose homeostasis among US
adults. Ann Epidemiol. 2014;24(2):90–7.
52. Alonso-Magdalena P, Morimoto S, Ripoll C, Fuentes E, Nadal A. The estrogenic effect
of bisphenol A disrupts pancreatic β-cell function in vivo and induces insulin resistance.
Environ Health Perspect. 2005;114(1):106–12.
53. Gray SL, Shaw AC, Gagne AX, Chan HM. Chronic exposure to PCBs (Aroclor 1254) exacerbates obesity-induced insulin resistance and hyperinsulinemia in mice. J Toxicol Environ
Health A. 2013;76(12):701–15.. Epub 2013/08/29. eng
54. Bell JA, Kivimaki M, Hamer M. Metabolically healthy obesity and risk of incident type 2
diabetes: a meta-analysis of prospective cohort studies. Obes Rev. 2014;15(6):504–15.
55. Lee D-H, Lind PM, Jacobs DR, Salihovic S, Van Bavel B, Lind L. Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the
elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study.
Diabetes Care. 2011;34(8):1778–84.
11 Role of Polychlorinated Biphenyls as EDCs in Metabolic Disorders
38. Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, et al. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology. 2010;139(2):653–63.
39. Senft AP, Dalton TP, Nebert DW, Genter MB, Hutchinson RJ, Shertzer HG. Dioxin
increases reactive oxygen production in mouse liver mitochondria. Toxicol Appl Pharmacol.
2002;178(1):15–21.
40. Aly HA, Domènech Ò. Cytotoxicity and mitochondrial dysfunction of 2, 3, 7,
8- tetrachlorodibenzo-p-dioxin (TCDD) in isolated rat hepatocytes. Toxicol Lett.
2009;191(1):79–87.
41. Hwang HJ, Dornbos P, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ. Mitochondrialtargeted aryl hydrocarbon receptor and the impact of 2, 3, 7, 8-tetrachlorodibenzo-pdioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol.
2016;304:121–32.
42. Senft AP, Dalton TP, Nebert DW, Genter MB, Puga A, Hutchinson RJ, et al. Mitochondrial
reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free Radic
Biol Med. 2002;33(9):1268–78.
43. Duval C, Teixeira-Clerc F, Leblanc AF, Touch S, Emond C, Guerre-Millo M, et al. Chronic
exposure to low doses of dioxin promotes liver fibrosis development in the C57BL/6J dietinduced obesity mouse model. Environ Health Perspect. 2016;125(3):428–36.
44. Heindel JJ, Blumberg B, Cave M, Machtinger R, Mantovani A, Mendez MA, et al. Metabolism
disrupting chemicals and metabolic disorders. Reprod Toxicol. 2017;68:3–33.
45. Chamorro-García R, Sahu M, Abbey RJ, Laude J, Pham N, Blumberg B. Transgenerational
inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis
elicited by prenatal exposure to the obesogen tributyltin in mice. Environ Health Perspect.
2013;121(3):359–66.
46. Ghosh S, Murinova L, Trnovec T, Loffredo CA, Washington K, Mitra PS, et al. Biomarkers
linking PCB exposure and obesity. Curr Pharm Biotechnol. 2014;15(11):1058–68.
47. Valvi D, Mendez MA, Martinez D, Grimalt JO, Torrent M, Sunyer J, et al. Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study. Environ Health Perspect. 2011;120(3):451–7.
48. Casas M, Nieuwenhuijsen M, Martínez D, Ballester F, Basagaña X, Basterrechea M, et al.
Prenatal exposure to PCB-153, p, p′-DDE and birth outcomes in 9000 mother–child pairs:
Exposure–response relationship and effect modifiers. Environ Int. 2015;74:23–31.
49. Liu Y, Peterson KE. Maternal exposure to synthetic chemicals and obesity in the offspring:
recent findings. Curr Environ Health Rep. 2015;2(4):339–47.
50. Suarez-Lopez JR, Lee D-H, Porta M, Steffes MW, Jacobs DR Jr. Persistent organic pollutants
in young adults and changes in glucose related metabolism over a 23-year follow-up. Environ
Res. 2015;137:485–94.
51. Beydoun HA, Khanal S, Zonderman AB, Beydoun MA. Sex differences in the association of
urinary bisphenol-A concentration with selected indices of glucose homeostasis among US
adults. Ann Epidemiol. 2014;24(2):90–7.
52. Alonso-Magdalena P, Morimoto S, Ripoll C, Fuentes E, Nadal A. The estrogenic effect
of bisphenol A disrupts pancreatic β-cell function in vivo and induces insulin resistance.
Environ Health Perspect. 2005;114(1):106–12.
53. Gray SL, Shaw AC, Gagne AX, Chan HM. Chronic exposure to PCBs (Aroclor 1254) exacerbates obesity-induced insulin resistance and hyperinsulinemia in mice. J Toxicol Environ
Health A. 2013;76(12):701–15.. Epub 2013/08/29. eng
54. Bell JA, Kivimaki M, Hamer M. Metabolically healthy obesity and risk of incident type 2
diabetes: a meta-analysis of prospective cohort studies. Obes Rev. 2014;15(6):504–15.
55. Lee D-H, Lind PM, Jacobs DR, Salihovic S, Van Bavel B, Lind L. Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the
elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study.
Diabetes Care. 2011;34(8):1778–84.
11 Role of Polychlorinated Biphenyls as EDCs in Metabolic Disorders