170
19. Ruder AM, Hein MJ, Hopf NB, Waters MA. Mortality among 24,865 workers exposed to
polychlorinated biphenyls (PCBs) in three electrical capacitor manufacturing plants: a tenyear update. Int J Hyg Environ Health. 2014;217(2):176–87.
20. Safe SH. Hazard and risk assessment of chemical mixtures using the toxic equivalency factor
approach. Environ Health Perspect. 1998;106(suppl 4):1051–8.
21. Murphy MO, Petriello MC, Han SG, Sunkara M, Morris AJ, Esser K, et al. Exercise protects
against PCB-induced inflammation and associated cardiovascular risk factors. Environ Sci
Pollut Res. 2016;23(3):2201–11.
22. Nishihara Y, Utsumi K. 2, 5, 2′, 5'-Tetrachlorobiphenyl impairs the bioenergetic functions of
isolated rat liver mitochondria. Biochem Pharmacol. 1986;35(19):3335–9.
23. Nishihara Y, Robertson L, Oesch F, Utsumi K. The effects of tetrachlorobiphenyls on the
electron transfer reaction of isolated rat liver mitochondria. Life Sci. 1986;38(7):627–35.
24. Mildaziene V, Nauciene Z, Baniene R, Grigiene J. Multiple effects of 2, 2, 5,
5- tetrachlorobiphenyl on oxidative phosphorylation in rat liver mitochondria. Toxicol Sci.
2002;65(2):220–7.
25. Aly HA, Domènech Ò. Aroclor 1254 induced cytotoxicity and mitochondrial dysfunction in
isolated rat hepatocytes. Toxicology. 2009;262(3):175–83.
26. Hennig B, Reiterer G, Toborek M, Matveev SV, Daugherty A, Smart E, et al. Dietary fat
interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density
lipoprotein receptor. Environ Health Perspect. 2004;113(1):83–7.
27. Shi X, Wahlang B, Wei X, Yin X, Falkner KC, Prough RA, et al. Metabolomic analysis of
the effects of polychlorinated biphenyls in nonalcoholic fatty liver disease. J Proteome Res.
2012;11(7):3805–15.
28. Wahlang B, Falkner KC, Gregory B, Ansert D, Young D, Conklin DJ, et al. Polychlorinated
biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in
male C57BL6/J mice. J Nutr Biochem. 2013;24(9):1587–95.
29. Arzuaga X, Reiterer G, Majkova Z, Kilgore MW, Toborek M, Hennig B. PPARα ligands
reduce PCB-induced endothelial activation: possible interactions in inflammation and atherosclerosis. Cardiovasc Toxicol. 2007;7(4):264–72.
30. Boverhof DR, Burgoon LD, Tashiro C, Chittim B, Harkema JR, Jump DB, et al. Temporal
and dose-dependent hepatic gene expression patterns in mice provide new insights into
TCDD-Mediated hepatotoxicity. Toxicol Sci. 2005;85(2):1048–63.
31. Lu H, Cui W, Klaassen CD. Nrf2 protects against 2, 3, 7, 8-tetrachlorodibenzo-pdioxin (TCDD)-induced oxidative injury and steatohepatitis. Toxicol Appl Pharmacol.
2011;256(2):122–35.
32. Angrish MM, Mets BD, Jones AD, Zacharewski TR. Dietary fat is a lipid source in 2, 3, 7,
8-tetrachlorodibenzo-ρ-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice. Toxicol
Sci. 2012;128(2):377–86.
33. Al-Eryani L, Wahlang B, Falkner K, Guardiola J, Clair H, Prough R, et al. Identification of
environmental chemicals associated with the development of toxicant-associated fatty liver
disease in rodents. Toxicol Pathol. 2015;43(4):482–97.
34. Nault R, Fader KA, Lydic TA, Zacharewski TR. Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice elicited by 2, 3, 7,
8- tetrachlorodibenzo-p-dioxin. Chem Res Toxicol. 2017;30(4):1060–75.
35. Pierre S, Chevallier A, Teixeira-Clerc F, Ambolet-Camoit A, Bui L-C, Bats A-S, et al.
Aryl hydrocarbon receptor–dependent induction of liver fibrosis by dioxin. Toxicol Sci.
2013;137(1):114–24.
36. Lakshman M, Ghosh P, Chirtel S. Mechanism of action of 2, 3, 7, 8-tetrachlorodibenzo-pdioxin on intermediary metabolism in the rat. J Pharmacol Exp Ther. 1991;258(1):317–9.
37. Kawano Y, Nishiumi S, Tanaka S, Nobutani K, Miki A, Yano Y, et al. Activation of the aryl
hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport.
Arch Biochem Biophys. 2010;504(2):221–7.
W. Hassan et al.
19. Ruder AM, Hein MJ, Hopf NB, Waters MA. Mortality among 24,865 workers exposed to
polychlorinated biphenyls (PCBs) in three electrical capacitor manufacturing plants: a tenyear update. Int J Hyg Environ Health. 2014;217(2):176–87.
20. Safe SH. Hazard and risk assessment of chemical mixtures using the toxic equivalency factor
approach. Environ Health Perspect. 1998;106(suppl 4):1051–8.
21. Murphy MO, Petriello MC, Han SG, Sunkara M, Morris AJ, Esser K, et al. Exercise protects
against PCB-induced inflammation and associated cardiovascular risk factors. Environ Sci
Pollut Res. 2016;23(3):2201–11.
22. Nishihara Y, Utsumi K. 2, 5, 2′, 5'-Tetrachlorobiphenyl impairs the bioenergetic functions of
isolated rat liver mitochondria. Biochem Pharmacol. 1986;35(19):3335–9.
23. Nishihara Y, Robertson L, Oesch F, Utsumi K. The effects of tetrachlorobiphenyls on the
electron transfer reaction of isolated rat liver mitochondria. Life Sci. 1986;38(7):627–35.
24. Mildaziene V, Nauciene Z, Baniene R, Grigiene J. Multiple effects of 2, 2, 5,
5- tetrachlorobiphenyl on oxidative phosphorylation in rat liver mitochondria. Toxicol Sci.
2002;65(2):220–7.
25. Aly HA, Domènech Ò. Aroclor 1254 induced cytotoxicity and mitochondrial dysfunction in
isolated rat hepatocytes. Toxicology. 2009;262(3):175–83.
26. Hennig B, Reiterer G, Toborek M, Matveev SV, Daugherty A, Smart E, et al. Dietary fat
interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density
lipoprotein receptor. Environ Health Perspect. 2004;113(1):83–7.
27. Shi X, Wahlang B, Wei X, Yin X, Falkner KC, Prough RA, et al. Metabolomic analysis of
the effects of polychlorinated biphenyls in nonalcoholic fatty liver disease. J Proteome Res.
2012;11(7):3805–15.
28. Wahlang B, Falkner KC, Gregory B, Ansert D, Young D, Conklin DJ, et al. Polychlorinated
biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in
male C57BL6/J mice. J Nutr Biochem. 2013;24(9):1587–95.
29. Arzuaga X, Reiterer G, Majkova Z, Kilgore MW, Toborek M, Hennig B. PPARα ligands
reduce PCB-induced endothelial activation: possible interactions in inflammation and atherosclerosis. Cardiovasc Toxicol. 2007;7(4):264–72.
30. Boverhof DR, Burgoon LD, Tashiro C, Chittim B, Harkema JR, Jump DB, et al. Temporal
and dose-dependent hepatic gene expression patterns in mice provide new insights into
TCDD-Mediated hepatotoxicity. Toxicol Sci. 2005;85(2):1048–63.
31. Lu H, Cui W, Klaassen CD. Nrf2 protects against 2, 3, 7, 8-tetrachlorodibenzo-pdioxin (TCDD)-induced oxidative injury and steatohepatitis. Toxicol Appl Pharmacol.
2011;256(2):122–35.
32. Angrish MM, Mets BD, Jones AD, Zacharewski TR. Dietary fat is a lipid source in 2, 3, 7,
8-tetrachlorodibenzo-ρ-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice. Toxicol
Sci. 2012;128(2):377–86.
33. Al-Eryani L, Wahlang B, Falkner K, Guardiola J, Clair H, Prough R, et al. Identification of
environmental chemicals associated with the development of toxicant-associated fatty liver
disease in rodents. Toxicol Pathol. 2015;43(4):482–97.
34. Nault R, Fader KA, Lydic TA, Zacharewski TR. Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice elicited by 2, 3, 7,
8- tetrachlorodibenzo-p-dioxin. Chem Res Toxicol. 2017;30(4):1060–75.
35. Pierre S, Chevallier A, Teixeira-Clerc F, Ambolet-Camoit A, Bui L-C, Bats A-S, et al.
Aryl hydrocarbon receptor–dependent induction of liver fibrosis by dioxin. Toxicol Sci.
2013;137(1):114–24.
36. Lakshman M, Ghosh P, Chirtel S. Mechanism of action of 2, 3, 7, 8-tetrachlorodibenzo-pdioxin on intermediary metabolism in the rat. J Pharmacol Exp Ther. 1991;258(1):317–9.
37. Kawano Y, Nishiumi S, Tanaka S, Nobutani K, Miki A, Yano Y, et al. Activation of the aryl
hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport.
Arch Biochem Biophys. 2010;504(2):221–7.
W. Hassan et al.