xiii
tical products waste, and parabens. As we also have laboratory experience working
on some of these EDCs to experimentally explore the mechanistic details of them
by inducing pathological alteration and causing diseases like hepatotoxicity, mutagenicity, nephrotoxicity, genotoxicity, teratogenicity, and immunotoxicity, we also
felt the potential urge for exposing the roles of bisphenol A (a toxic, mutagenic,
carcinogenic, and endocrine disruptor) and aflatoxins (substituted bisfuranocoumarins, a secondary fungal metabolite).
We think that this communal etiology we have so far provided from the introduction of endocrinology till the dysfunction and occurrence of MDs with a potential
role of EDCs can significantly support the need for a better understanding of these
dysfunctions to reveal unusual therapeutic targets for the development of pharmaceutical drugs. This can be achieved by utilizing nanotechnology, a rapidly flourishing field that has emerged as cutting-edge technology in the twenty-first century
indicating a promising future. Therefore, we are successful in showing how such
novel technologies along with other therapeutic candidate molecules or techniques
and/or preventive methods can ameliorate the hazardous effects of EDCs that occur
in the form of induction and prevalence of MDs. The most important ones that we
have discussed here, though certainly not the only ones, are the roles of nanoparticles in the management of metabolic disorders, intermittent fasting, herbs, and
spices as a natural medicine for MDs. Similarly, bioactive compounds like polyphenols, phytosterols, carotenoids, prebiotics, vitamins, and flavonoids can effectively
be used in treating EDCs-induced diabetes mellitus, hypertension, obesity, hyperlipidemia, and non-alcoholic fatty liver disease.
The chapters given in this book actually depict a comprehensive view into the
rising areas of research in the pathobiology of EDCs-induced MDs. This book also
includes in-depth assessments on a variety of therapeutic targets of the endocrine
system that can be either focused on reverting the MDs or preventing enduring damage to bypass the occurrence and/or progression of MDs. We are confident that the
contents of this book will motivate and encourage not only the challenging deliberations but will also instigate innovative paths of research to further widen the information, awareness, and responsiveness towards pathogenic EDCs with the eventual
objective of rendering this information provided in this book into therapeutic
novelties.
Faisalabad, Pakistan
Muhammad Sajid Hamid Akash
Faisalabad, Pakistan
Kanwal Rehman
Islamabad, Pakistan
Muhammad Zaffar Hashmi
Preface
tical products waste, and parabens. As we also have laboratory experience working
on some of these EDCs to experimentally explore the mechanistic details of them
by inducing pathological alteration and causing diseases like hepatotoxicity, mutagenicity, nephrotoxicity, genotoxicity, teratogenicity, and immunotoxicity, we also
felt the potential urge for exposing the roles of bisphenol A (a toxic, mutagenic,
carcinogenic, and endocrine disruptor) and aflatoxins (substituted bisfuranocoumarins, a secondary fungal metabolite).
We think that this communal etiology we have so far provided from the introduction of endocrinology till the dysfunction and occurrence of MDs with a potential
role of EDCs can significantly support the need for a better understanding of these
dysfunctions to reveal unusual therapeutic targets for the development of pharmaceutical drugs. This can be achieved by utilizing nanotechnology, a rapidly flourishing field that has emerged as cutting-edge technology in the twenty-first century
indicating a promising future. Therefore, we are successful in showing how such
novel technologies along with other therapeutic candidate molecules or techniques
and/or preventive methods can ameliorate the hazardous effects of EDCs that occur
in the form of induction and prevalence of MDs. The most important ones that we
have discussed here, though certainly not the only ones, are the roles of nanoparticles in the management of metabolic disorders, intermittent fasting, herbs, and
spices as a natural medicine for MDs. Similarly, bioactive compounds like polyphenols, phytosterols, carotenoids, prebiotics, vitamins, and flavonoids can effectively
be used in treating EDCs-induced diabetes mellitus, hypertension, obesity, hyperlipidemia, and non-alcoholic fatty liver disease.
The chapters given in this book actually depict a comprehensive view into the
rising areas of research in the pathobiology of EDCs-induced MDs. This book also
includes in-depth assessments on a variety of therapeutic targets of the endocrine
system that can be either focused on reverting the MDs or preventing enduring damage to bypass the occurrence and/or progression of MDs. We are confident that the
contents of this book will motivate and encourage not only the challenging deliberations but will also instigate innovative paths of research to further widen the information, awareness, and responsiveness towards pathogenic EDCs with the eventual
objective of rendering this information provided in this book into therapeutic
novelties.
Faisalabad, Pakistan
Muhammad Sajid Hamid Akash
Faisalabad, Pakistan
Kanwal Rehman
Islamabad, Pakistan
Muhammad Zaffar Hashmi
Preface