Raol YH, Brooks-Kayal AR (2012) Experimental models of seizures and epilepsies. Prog Mol
Biol Transl Sci 105:57–82
Rathod SS (2014) Extraction of piperine from Piper longum using ultrasound. Industr Crops Prod
58:259–264
Rauscher FM, Sanders RA, Watkins Iii JB (2000) Effects of piperine on antioxidant pathways in
tissues from normal and streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 14
(6):329–334
Reddy AC, Lokesh BR (1992) Studies on spice principles as antioxidants in the inhibition of lipid
peroxidation of rat liver microsomes. Mol Cell Biochem 111(1–2):117–124
Reen RK, Singh J (1991) In vitro and in vivo inhibition of pulmonary cytochrome P450 activities
by piperine, a major ingredient of piper species. Indian J Exp Biol 29(6):568–573
Ren T, Hu M, Cheng Y, Shek TL, Xiao M, Ho NJ, Zhang C, Leung SSY, Zuo Z (2019a)
Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy
control. Eur J Pharm Sci 137:104988
Ren T, Yang M, Xiao M, Zhu J, Xie W, Zuo Z (2019b) Time-dependent inhibition of
carbamazepine metabolism by piperine in anti-epileptic treatment. Life Sci 218:314–323
Ren T, Zuo Z (2019) Role of piperine in CNS diseases: pharmacodynamics, pharmacokinetics and
drug interactions. Expert Opin Drug Metab Toxicol 15(10):849–867
Ridderstad Wollberg A, Ericsson-Dahlstrand A, Juréus A, Ekerot P, Simon S, Nilsson M,
Wiklund SJ, Berg AL, Ferm M, Sunnemark D, Johansson R (2014) Pharmacological inhibition
of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for
multiple sclerosis. Proc Natl Acad Sci U S a 111(14):5409–5414
Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbí AL, Sánchez-Mateos
P, Rodríguez-Fernández JL (2005) The chemokine receptor CCR7 activates in dendritic cells
two signaling modules that independently regulate chemotaxis and migratory speed. J Immunol
174(7):4070–4080
Rode S, Bhujbal P, Sandhya P (2013) Quantification of piperine and 18-b glycyrrhetinic acid in
herbal formulation “Eladi Gutika.” Acta Chromatographica 25(1):135–146
Rodgers G, Doucette CD, Soutar DA, Liwski RS, Hoskin DW (2016) Piperine impairs the
migration and T cell-activating function of dendritic cells. Toxicol Lett 242:23–33
Roshanbakhsh H, Elahdadi Salmani M, Dehghan S, Nazari A, Javan M, Pourabdolhossein F
(2020) Piperine ameliorated memory impairment and myelin damage in lysolecethin induced
hippocampal demyelination. Life Sci 253:117671
Rout K, Rout O, Mishra S (2007) Estimation of piperine in commercial Ayurvedic formulations.
J Planar Chromatogr – Modern TLC 20(6): 447–450
Sachan N, Chandra P, Pal D (2015) Assessment of gastroprotective potential of Delonix regia (Boj
Ex Hook) Raf against ethanol and cold restrain stress-induced ulcer in rats. Trop J Pharm Res
14(6):1063–1070
Saha S, Pal D (2016) Molecular Docking, synthesis, in vitro HDAC inhibition activity and
antiproliferative activity against breast cancer cell line of hydroxyacetamide derivatives. Trop J
Pharm Res 15(7):1401–1411
Sakagami Y, Mizoguchi Y, Seki S, Kobayashi K, Morisawa S, Yamamoto S (1989) Effect of
arachidonate derivatives on cell viability in isolated rat hepatocytes: cytotoxicity of
15-hydroperoxyeicosatetraenoic acid. Gastroenterol Jpn 24(5):583
Samuel M, Oliver SV, Coetzee M, Brooke BD (2016) The larvicidal effects of black pepper (Piper
nigrum L.) and piperine against insecticide resistant and susceptible strains of Anopheles
malaria vector mosquitoes. Parasites Vectors 9(1): 238
Sánchez-Sánchez N, Riol-Blanco L, Rodríguez-Fernández JL (2006) The multiple personalities of
the chemokine receptor CCR7 in dendritic cells. J Immunol 176(9):5153–5159
Sannigrahi S, Mazumder UK, Pal D, Mishra SL (2012) Terpenoids of methanol extract of C.
infortunatum exhibit anticancer activity against Ehrlich’s ascites carcinoma (EAC) in mice.
Pharm Biol 50(3): 304–309
22 Piperine: Sources, Properties, Applications …
789
Biol Transl Sci 105:57–82
Rathod SS (2014) Extraction of piperine from Piper longum using ultrasound. Industr Crops Prod
58:259–264
Rauscher FM, Sanders RA, Watkins Iii JB (2000) Effects of piperine on antioxidant pathways in
tissues from normal and streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 14
(6):329–334
Reddy AC, Lokesh BR (1992) Studies on spice principles as antioxidants in the inhibition of lipid
peroxidation of rat liver microsomes. Mol Cell Biochem 111(1–2):117–124
Reen RK, Singh J (1991) In vitro and in vivo inhibition of pulmonary cytochrome P450 activities
by piperine, a major ingredient of piper species. Indian J Exp Biol 29(6):568–573
Ren T, Hu M, Cheng Y, Shek TL, Xiao M, Ho NJ, Zhang C, Leung SSY, Zuo Z (2019a)
Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy
control. Eur J Pharm Sci 137:104988
Ren T, Yang M, Xiao M, Zhu J, Xie W, Zuo Z (2019b) Time-dependent inhibition of
carbamazepine metabolism by piperine in anti-epileptic treatment. Life Sci 218:314–323
Ren T, Zuo Z (2019) Role of piperine in CNS diseases: pharmacodynamics, pharmacokinetics and
drug interactions. Expert Opin Drug Metab Toxicol 15(10):849–867
Ridderstad Wollberg A, Ericsson-Dahlstrand A, Juréus A, Ekerot P, Simon S, Nilsson M,
Wiklund SJ, Berg AL, Ferm M, Sunnemark D, Johansson R (2014) Pharmacological inhibition
of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for
multiple sclerosis. Proc Natl Acad Sci U S a 111(14):5409–5414
Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbí AL, Sánchez-Mateos
P, Rodríguez-Fernández JL (2005) The chemokine receptor CCR7 activates in dendritic cells
two signaling modules that independently regulate chemotaxis and migratory speed. J Immunol
174(7):4070–4080
Rode S, Bhujbal P, Sandhya P (2013) Quantification of piperine and 18-b glycyrrhetinic acid in
herbal formulation “Eladi Gutika.” Acta Chromatographica 25(1):135–146
Rodgers G, Doucette CD, Soutar DA, Liwski RS, Hoskin DW (2016) Piperine impairs the
migration and T cell-activating function of dendritic cells. Toxicol Lett 242:23–33
Roshanbakhsh H, Elahdadi Salmani M, Dehghan S, Nazari A, Javan M, Pourabdolhossein F
(2020) Piperine ameliorated memory impairment and myelin damage in lysolecethin induced
hippocampal demyelination. Life Sci 253:117671
Rout K, Rout O, Mishra S (2007) Estimation of piperine in commercial Ayurvedic formulations.
J Planar Chromatogr – Modern TLC 20(6): 447–450
Sachan N, Chandra P, Pal D (2015) Assessment of gastroprotective potential of Delonix regia (Boj
Ex Hook) Raf against ethanol and cold restrain stress-induced ulcer in rats. Trop J Pharm Res
14(6):1063–1070
Saha S, Pal D (2016) Molecular Docking, synthesis, in vitro HDAC inhibition activity and
antiproliferative activity against breast cancer cell line of hydroxyacetamide derivatives. Trop J
Pharm Res 15(7):1401–1411
Sakagami Y, Mizoguchi Y, Seki S, Kobayashi K, Morisawa S, Yamamoto S (1989) Effect of
arachidonate derivatives on cell viability in isolated rat hepatocytes: cytotoxicity of
15-hydroperoxyeicosatetraenoic acid. Gastroenterol Jpn 24(5):583
Samuel M, Oliver SV, Coetzee M, Brooke BD (2016) The larvicidal effects of black pepper (Piper
nigrum L.) and piperine against insecticide resistant and susceptible strains of Anopheles
malaria vector mosquitoes. Parasites Vectors 9(1): 238
Sánchez-Sánchez N, Riol-Blanco L, Rodríguez-Fernández JL (2006) The multiple personalities of
the chemokine receptor CCR7 in dendritic cells. J Immunol 176(9):5153–5159
Sannigrahi S, Mazumder UK, Pal D, Mishra SL (2012) Terpenoids of methanol extract of C.
infortunatum exhibit anticancer activity against Ehrlich’s ascites carcinoma (EAC) in mice.
Pharm Biol 50(3): 304–309
22 Piperine: Sources, Properties, Applications …
789