Sarkar B, Tiwari S, Patel R, Dubey G (2011) High performance thin layer chromatographic
method for quantification of piperine in an ayurvedic formulation. Asian J Pharm Life Sci 1
(2):128–132
Schöbel N, Radtke D, Lübbert M, Gisselmann G, Lehmann R, Cichy A, Schreiner BS, Altmüller J,
Spector AC, Spehr J, Hatt H, Wetzel CH (2012) Trigeminal ganglion neurons of mice show
intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced
responses. PLoS ONE 7(11):e48005
Schönherr R (2005) Clinical relevance of ion channels for diagnosis and therapy of cancer.
J Membr Biol 205(3):175–184
Schulz JB, Weller M, Klockgether T (1996) Potassium deprivation-induced apoptosis of cerebellar
granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like
protease activity, and reactive oxygen species. J Neurosci 16(15):4696–4706
Shailajan S, Sayed N, Joshi H, Tiwary B (2011) Standardization of an ayurvedic formulation:
Trikatu Churna using bioanalytical tools. Int J Res Ayurveda Pharm 2(6):1676–1678
Shao B, Cui C, Ji H, Tang J, Wang Z, Liu H, Qin M, Li X, Wu L (2015) Enhanced oral
bioavailability of piperine by self-emulsifying drug delivery systems: in vitro, in vivo and
in situ intestinal permeability studies. Drug Deliv 22(6):740–747
Sigrist S, Franco-Cereceda A, Muff R, Henke H, Lundberg JM, Fischer JA (1986) Specific
receptor and cardiovascular effects of calcitonin gene-related peptide. Endocrinology 119
(1):381–389
Singh A, Pawar VK, Jakhmola V, Parabia MH, Awasthi R, Sharma G (2010) In Vivo assessment
of enhanced bioavailability of metronidazole with piperine in rabbits. Res J Pharm Biol Chem
Sci 1:273–278
Singh M, Varshneya C, Telang RS, Srivastava AK (2005) Alteration of pharmacokinetics of
oxytetracycline following oral administration of Piper longum in hens. J Vet Sci 6(3):197–200
Singh NK, Kumar P, Gupta DK, Singh S, Singh VK (2011) UV-spectrophotometric method
development for estimation of piperine in Chitrakadi Vati. Der Pharmacia Lettre 3(3):178–182
Soutar DA, Doucette CD, Liwski RS, Hoskin DW (2017) Piperine, a Pungent Alkaloid from Black
Pepper, Inhibits B Lymphocyte Activation and Effector Functions. Phytotherapy Research 31
(3):466–474
Sunila ES, Kuttan G (2004) Immunomodulatory and antitumor activity of Piper longum Linn. and
piperine. J Ethnopharm 90(2):339–346
Thurman JM (2007) Triggers of inflammation after renal ischemia/reperfusion. Clin Immunol 123
(1):7–13
Tomson T, Almkvist O, Nilsson BY, Svensson JO, Bertilsson L (1990) Carbamazepine-10,
11-epoxide in epilepsy pilot study. Arch Neurol 47(8):888–892
Trinchieri G, Sher A (2007) Cooperation of Toll-like receptor signals in innate immune defence.
Nat Rev Immunol 7(3):179–190
Unchern S, Saito H, Nishiyama N (1997) Selective cytotoxicity of piperine on cultured rat
hippocampal neurons in comparison with cultured astrocytes: the possible involvement of lipid
peroxidation. Biol Pharm Bull 20(9):958–961
Unchern S, Saito H, Nishiyama N (1998) Death of cerebellar granule neurons induced by piperine
is distinct from that induced by low potassium medium. Neurochem Res 23(1):97–102
Vyas A, Jain V, Singh D, Singh M, Shukla SS, Pandey R, Swarnlata S, Saraf S (2011) TLC
densitometric method for the estimation of piperine in ayurvedic formulation Trikatu churna.
Orient J Chem 27(1):301–304
Williams HD, Trevaskis NL, Charman SA, Shanker RM, Charman WN, Pouton CW, Porter CJH
(2013) Strategies to address low drug solubility in discovery and development. Pharmacol Rev
65(1):315
Wolff SP (1993) Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative
stress in the aetiology of diabetes mellitus and complications. Br Med Bull 49(3):642–652
Wonderlin WF, Strobl JS (1996) Potassium channels, proliferation and G1 progression. J Membr
Biol 154(2):91–107
790
N. Sachan et al.
method for quantification of piperine in an ayurvedic formulation. Asian J Pharm Life Sci 1
(2):128–132
Schöbel N, Radtke D, Lübbert M, Gisselmann G, Lehmann R, Cichy A, Schreiner BS, Altmüller J,
Spector AC, Spehr J, Hatt H, Wetzel CH (2012) Trigeminal ganglion neurons of mice show
intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced
responses. PLoS ONE 7(11):e48005
Schönherr R (2005) Clinical relevance of ion channels for diagnosis and therapy of cancer.
J Membr Biol 205(3):175–184
Schulz JB, Weller M, Klockgether T (1996) Potassium deprivation-induced apoptosis of cerebellar
granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like
protease activity, and reactive oxygen species. J Neurosci 16(15):4696–4706
Shailajan S, Sayed N, Joshi H, Tiwary B (2011) Standardization of an ayurvedic formulation:
Trikatu Churna using bioanalytical tools. Int J Res Ayurveda Pharm 2(6):1676–1678
Shao B, Cui C, Ji H, Tang J, Wang Z, Liu H, Qin M, Li X, Wu L (2015) Enhanced oral
bioavailability of piperine by self-emulsifying drug delivery systems: in vitro, in vivo and
in situ intestinal permeability studies. Drug Deliv 22(6):740–747
Sigrist S, Franco-Cereceda A, Muff R, Henke H, Lundberg JM, Fischer JA (1986) Specific
receptor and cardiovascular effects of calcitonin gene-related peptide. Endocrinology 119
(1):381–389
Singh A, Pawar VK, Jakhmola V, Parabia MH, Awasthi R, Sharma G (2010) In Vivo assessment
of enhanced bioavailability of metronidazole with piperine in rabbits. Res J Pharm Biol Chem
Sci 1:273–278
Singh M, Varshneya C, Telang RS, Srivastava AK (2005) Alteration of pharmacokinetics of
oxytetracycline following oral administration of Piper longum in hens. J Vet Sci 6(3):197–200
Singh NK, Kumar P, Gupta DK, Singh S, Singh VK (2011) UV-spectrophotometric method
development for estimation of piperine in Chitrakadi Vati. Der Pharmacia Lettre 3(3):178–182
Soutar DA, Doucette CD, Liwski RS, Hoskin DW (2017) Piperine, a Pungent Alkaloid from Black
Pepper, Inhibits B Lymphocyte Activation and Effector Functions. Phytotherapy Research 31
(3):466–474
Sunila ES, Kuttan G (2004) Immunomodulatory and antitumor activity of Piper longum Linn. and
piperine. J Ethnopharm 90(2):339–346
Thurman JM (2007) Triggers of inflammation after renal ischemia/reperfusion. Clin Immunol 123
(1):7–13
Tomson T, Almkvist O, Nilsson BY, Svensson JO, Bertilsson L (1990) Carbamazepine-10,
11-epoxide in epilepsy pilot study. Arch Neurol 47(8):888–892
Trinchieri G, Sher A (2007) Cooperation of Toll-like receptor signals in innate immune defence.
Nat Rev Immunol 7(3):179–190
Unchern S, Saito H, Nishiyama N (1997) Selective cytotoxicity of piperine on cultured rat
hippocampal neurons in comparison with cultured astrocytes: the possible involvement of lipid
peroxidation. Biol Pharm Bull 20(9):958–961
Unchern S, Saito H, Nishiyama N (1998) Death of cerebellar granule neurons induced by piperine
is distinct from that induced by low potassium medium. Neurochem Res 23(1):97–102
Vyas A, Jain V, Singh D, Singh M, Shukla SS, Pandey R, Swarnlata S, Saraf S (2011) TLC
densitometric method for the estimation of piperine in ayurvedic formulation Trikatu churna.
Orient J Chem 27(1):301–304
Williams HD, Trevaskis NL, Charman SA, Shanker RM, Charman WN, Pouton CW, Porter CJH
(2013) Strategies to address low drug solubility in discovery and development. Pharmacol Rev
65(1):315
Wolff SP (1993) Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative
stress in the aetiology of diabetes mellitus and complications. Br Med Bull 49(3):642–652
Wonderlin WF, Strobl JS (1996) Potassium channels, proliferation and G1 progression. J Membr
Biol 154(2):91–107
790
N. Sachan et al.