Koleva II, van Beek TA, Soffers AE, Dusemund B, Rietjens IM (2012) Alkaloids in the human
food chain–natural occurrence and possible adverse effects. Mol Nutr Food Res 56(1):30–52
Korsmeyer SJ, Yin XM, Oltvai ZN, Veis-Novack DJ, Linette GP (1995) Reactive oxygen species
and the regulation of cell death by the Bcl-2 gene family. Biochim Biophys Acta 1271(1):63–
66
Kumar S, Singhal V, Roshan R, Sharma A, Rembhotkar GW, Ghosh B (2007) Piperine inhibits
TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of
NF-kappaB and IkappaB kinase activation. Eur J Pharmacol 575(1–3):177–186
Kurts C, Panzer U, Anders HJ, Rees AJ (2013) The immune system and kidney disease: basic
concepts and clinical implications. Nat Rev Immunol 13(10):738–753
Lassmann H, Bradl M (2017) Multiple sclerosis: experimental models and reality. Acta
Neuropathol 133(2):223–244
Li C, Wang Z, Wang Q, Ka Yan Ho RL, Huang Y, Chow MSS, Kei Lam CW, Zuo Z (2018)
Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination- in vitro and in vivo investigation using a taxane-resistant prostate cancer model.
Oncotarget 9(3):3338–3352
Li S, Wang C, Li W, Koike K, Nikaido T, Wang MW (2007) Antidepressant-like effects of
piperine and its derivative, antiepilepsirine. J Asian Nat Prod Res 9(3–5):421–430
Ling H, Edelstein C, Gengaro P, Meng X, Lucia S, Knotek M, Wangsiripaisan A, Shi Y, Schrier R
(1999) Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase
knockout mice. Am J Physiol 277(3):F383-390
Liu Z, Hu Q, Wang W, Lu S, Wu D, Ze S, He J, Huang Y, Chen W, Xu Y, Lu W, Huang J (2020)
Natural product piperine alleviates experimental allergic encephalomyelitis in mice by
targeting dihydroorotate dehydrogenase. Biochem Pharmacol 177: 114000
Lutz MB, Kukutsch N, Ogilvie ALJ, Rößner S, Koch F, Romani N, Schuler G (1999) An
advanced culture method for generating large quantities of highly pure dendritic cells from
mouse bone marrow. J Immunol Methods 223(1):77–92
Makar TK, Nedergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper AJ (1994) Vitamin E,
ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in
cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in
antioxidative processes in the brain. J Neurochem 62(1):45–53
Manley PW, Furet P, Bold G, Brüggen J, Mestan J, Meyer T, Schnell CR, Wood J, Haberey M,
Huth A, Krüger M, Menrad A, Ottow E, Seidelmann D, Siemeister G, Thierauch KH (2002)
Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors.
J Med Chem 45(26):5687–5693
Matough FA, Budin SB, Hamid ZA, Alwahaibi N, Mohamed J (2012) The role of oxidative stress
and antioxidants in diabetic complications. Sultan Qaboos University Med J 12(1):5–18
Matyszak MK, Citterio S, Rescigno M, Ricciardi-Castagnoli P (2000) Differential effects of
corticosteroids during different stages of dendritic cell maturation. Eur J Immunol 30(4):1233–
1242
McNamara FN, Randall A, Gunthorpe MJ (2005) Effects of piperine, the pungent component of
black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 144(6):781–790
Mishra A, Punia JK, Bladen C, Zamponi GW, Goel RK (2015) Anticonvulsant mechanisms of
piperine, a piperidine alkaloid. Channels 9(5):317–323
Miyauchi T, Ishikawa T, Sugishita Y, Saito A, Goto K (1987) Effects of capsaicin on
nonadrenergic noncholinergic nerves in the guinea pig atria: role of calcitonin gene-related
peptide as cardiac neurotransmitter. J Cardiovasc Pharmacol 10(6):675–682
Miyauchi T, Ishikawa T, Sugishita Y, Saito A, Goto K (1988) Effects of piperine on calcitonin
gene-related peptide (CGRP)-containing nerves in the isolated rat atria. Neurosci Lett 91
(2):222–227
Mohammadi M, Najafi H, Mohamadi Yarijani Z, Vaezi G, Hojati V (2019) Protective effect of
piperine in ischemia-reperfusion induced acute kidney injury through inhibition of inflammation and oxidative stress. J Trad Complem Med
22 Piperine: Sources, Properties, Applications …
787
food chain–natural occurrence and possible adverse effects. Mol Nutr Food Res 56(1):30–52
Korsmeyer SJ, Yin XM, Oltvai ZN, Veis-Novack DJ, Linette GP (1995) Reactive oxygen species
and the regulation of cell death by the Bcl-2 gene family. Biochim Biophys Acta 1271(1):63–
66
Kumar S, Singhal V, Roshan R, Sharma A, Rembhotkar GW, Ghosh B (2007) Piperine inhibits
TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of
NF-kappaB and IkappaB kinase activation. Eur J Pharmacol 575(1–3):177–186
Kurts C, Panzer U, Anders HJ, Rees AJ (2013) The immune system and kidney disease: basic
concepts and clinical implications. Nat Rev Immunol 13(10):738–753
Lassmann H, Bradl M (2017) Multiple sclerosis: experimental models and reality. Acta
Neuropathol 133(2):223–244
Li C, Wang Z, Wang Q, Ka Yan Ho RL, Huang Y, Chow MSS, Kei Lam CW, Zuo Z (2018)
Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination- in vitro and in vivo investigation using a taxane-resistant prostate cancer model.
Oncotarget 9(3):3338–3352
Li S, Wang C, Li W, Koike K, Nikaido T, Wang MW (2007) Antidepressant-like effects of
piperine and its derivative, antiepilepsirine. J Asian Nat Prod Res 9(3–5):421–430
Ling H, Edelstein C, Gengaro P, Meng X, Lucia S, Knotek M, Wangsiripaisan A, Shi Y, Schrier R
(1999) Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase
knockout mice. Am J Physiol 277(3):F383-390
Liu Z, Hu Q, Wang W, Lu S, Wu D, Ze S, He J, Huang Y, Chen W, Xu Y, Lu W, Huang J (2020)
Natural product piperine alleviates experimental allergic encephalomyelitis in mice by
targeting dihydroorotate dehydrogenase. Biochem Pharmacol 177: 114000
Lutz MB, Kukutsch N, Ogilvie ALJ, Rößner S, Koch F, Romani N, Schuler G (1999) An
advanced culture method for generating large quantities of highly pure dendritic cells from
mouse bone marrow. J Immunol Methods 223(1):77–92
Makar TK, Nedergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper AJ (1994) Vitamin E,
ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in
cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in
antioxidative processes in the brain. J Neurochem 62(1):45–53
Manley PW, Furet P, Bold G, Brüggen J, Mestan J, Meyer T, Schnell CR, Wood J, Haberey M,
Huth A, Krüger M, Menrad A, Ottow E, Seidelmann D, Siemeister G, Thierauch KH (2002)
Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors.
J Med Chem 45(26):5687–5693
Matough FA, Budin SB, Hamid ZA, Alwahaibi N, Mohamed J (2012) The role of oxidative stress
and antioxidants in diabetic complications. Sultan Qaboos University Med J 12(1):5–18
Matyszak MK, Citterio S, Rescigno M, Ricciardi-Castagnoli P (2000) Differential effects of
corticosteroids during different stages of dendritic cell maturation. Eur J Immunol 30(4):1233–
1242
McNamara FN, Randall A, Gunthorpe MJ (2005) Effects of piperine, the pungent component of
black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 144(6):781–790
Mishra A, Punia JK, Bladen C, Zamponi GW, Goel RK (2015) Anticonvulsant mechanisms of
piperine, a piperidine alkaloid. Channels 9(5):317–323
Miyauchi T, Ishikawa T, Sugishita Y, Saito A, Goto K (1987) Effects of capsaicin on
nonadrenergic noncholinergic nerves in the guinea pig atria: role of calcitonin gene-related
peptide as cardiac neurotransmitter. J Cardiovasc Pharmacol 10(6):675–682
Miyauchi T, Ishikawa T, Sugishita Y, Saito A, Goto K (1988) Effects of piperine on calcitonin
gene-related peptide (CGRP)-containing nerves in the isolated rat atria. Neurosci Lett 91
(2):222–227
Mohammadi M, Najafi H, Mohamadi Yarijani Z, Vaezi G, Hojati V (2019) Protective effect of
piperine in ischemia-reperfusion induced acute kidney injury through inhibition of inflammation and oxidative stress. J Trad Complem Med
22 Piperine: Sources, Properties, Applications …
787