Cotgreave IA, Moldéus P, Orrenius S (1988) Host biochemical defense mechanisms against
prooxidants. Annu Rev Pharmacol Toxicol 28:189–212
D’Hooge R, Pei YQ, Raes A, Lebrun P, van Bogaert PP, de Deyn PP (1996) Anticonvulsant
activity of piperine on seizures induced by excitatory amino acid receptor agonists.
Arzneimittelforschung 46(6):557–560
da Cruz GMP, Felipe CFB, Scorza FA, da Costa MAC, Tavares AF, Menezes MLF, de
Andrade GM, Leal LKAM, Brito GAC, da Graça N-M, Cavalheiro EA, de Barros Viana GS
(2013) Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Pharmacol Biochem Behav 104:144–153
Dama MS, Varshneya C, Dardi MS, Katoch VC (2008) Effect of trikatu pretreatment on the
pharmacokinetics of pefloxacin administered orally in mountain Gaddi goats. J Vet Sci 9
(1):25–29
de la Rosa M, Rutz S, Dorninger H, Scheffold A (2004) Interleukin-2 is essential for CD4+CD25+
regulatory T cell function. Eur J Immunol 34(9):2480–2488
Derosa G, Maffioli P, Sahebkar A (2016) Piperine and Its Role in Chronic Diseases. Adv Exp Med
Biol 928:173–184
Diplock AT (1982) The modulating influence of vitamin E in biological membrane unsaturated
phospholipid metabolism. Acta Vitaminol Enzymol 4(4):303–309
Eksioglu EA, Mahmood SS, Chang M, Reddy V (2007) GM-CSF promotes differentiation of
human dendritic cells and T lymphocytes toward a predominantly type 1 proinflammatory
response. Exp Hematol 35(8):1163–1171
Elnaggar YS, Etman SM, Abdelmonsif DA, Abdallah OY (2015) Novel piperine-loaded
Tween-integrated monoolein cubosomes as brain-targeted oral nanomedicine in Alzheimer’s
disease: pharmaceutical, biological, and toxicological studies. Int J Nanomedicine 10:5459–
5473
Fidler IJ (1985) Immunomodulation of macrophages for cancer and antiviral therapy. Wiley , New
York
Fidler IJ (1988) Targeting of immunomodulators to mononuclear phagocytes for therapy of cancer.
Adv Drug Deliv Rev 2(1):69–106
Fozzard HA, Lee PJ, Lipkind GM (2005) Mechanism of local anesthetic drug action on
voltage-gated sodium channels. Curr Pharm Des 11(21):2671–2686
Franco-Cereceda A, Lundberg JM (1985) Calcitonin gene-related peptide (CGRP) and
capsaicin-induced stimulation of heart contractile rate and force. Naunyn Schmiedebergs
Arch Pharmacol 331(2–3):146–151
Franco-Cereceda A, Lundberg JM, Saria A, Schreibmayer W, Tritthart HA (1988) Calcitonin
gene-related peptide: release by capsaicin and prolongation of the action potential in the
guinea-pig heart. Acta Physiol Scand 132(2):181–190
Fraser SP, Grimes JA, Djamgoz MB (2000) Effects of voltage-gated ion channel modulators on rat
prostatic cancer cell proliferation: comparison of strongly and weakly metastatic cell lines.
Prostate 44(1):61–76
Friese MA, Fugger L (2005) Autoreactive CD8+ T cells in multiple sclerosis: a new target for
therapy? Brain 128(Pt 8):1747–1763
Fu M, Sun ZH, Zuo HC (2010) Neuroprotective effect of piperine on primarily cultured
hippocampal neurons. Biol Pharm Bull 33(4):598–603
Gadermaier E, Levin M, Flicker S, Ohlin M (2014) The human IgE repertoire. Int Arch Allergy
Immunol 163(2):77–91
Gasior M, Kleinrok Z, Czuczwar SJ (1995) Influence of BAY k-8644, a calcium channel agonist,
on the anticonvulsant activity of conventional anti-epileptics against electroconvulsions in
mice. Neuropharmacology 34(4):433–438
Gasparini C, Feldmann M (2012) NF-jB as a target for modulating inflammatory responses. Curr
Pharm Des 18(35):5735–5745
George K, Thomas NS, Malathi R (2019) Piperine blocks voltage gated K(+) current and inhibits
proliferation in androgen sensitive and insensitive human prostate cancer cell lines. Arch
Biochem Biophys 667:36–48
22 Piperine: Sources, Properties, Applications …
785
prooxidants. Annu Rev Pharmacol Toxicol 28:189–212
D’Hooge R, Pei YQ, Raes A, Lebrun P, van Bogaert PP, de Deyn PP (1996) Anticonvulsant
activity of piperine on seizures induced by excitatory amino acid receptor agonists.
Arzneimittelforschung 46(6):557–560
da Cruz GMP, Felipe CFB, Scorza FA, da Costa MAC, Tavares AF, Menezes MLF, de
Andrade GM, Leal LKAM, Brito GAC, da Graça N-M, Cavalheiro EA, de Barros Viana GS
(2013) Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Pharmacol Biochem Behav 104:144–153
Dama MS, Varshneya C, Dardi MS, Katoch VC (2008) Effect of trikatu pretreatment on the
pharmacokinetics of pefloxacin administered orally in mountain Gaddi goats. J Vet Sci 9
(1):25–29
de la Rosa M, Rutz S, Dorninger H, Scheffold A (2004) Interleukin-2 is essential for CD4+CD25+
regulatory T cell function. Eur J Immunol 34(9):2480–2488
Derosa G, Maffioli P, Sahebkar A (2016) Piperine and Its Role in Chronic Diseases. Adv Exp Med
Biol 928:173–184
Diplock AT (1982) The modulating influence of vitamin E in biological membrane unsaturated
phospholipid metabolism. Acta Vitaminol Enzymol 4(4):303–309
Eksioglu EA, Mahmood SS, Chang M, Reddy V (2007) GM-CSF promotes differentiation of
human dendritic cells and T lymphocytes toward a predominantly type 1 proinflammatory
response. Exp Hematol 35(8):1163–1171
Elnaggar YS, Etman SM, Abdelmonsif DA, Abdallah OY (2015) Novel piperine-loaded
Tween-integrated monoolein cubosomes as brain-targeted oral nanomedicine in Alzheimer’s
disease: pharmaceutical, biological, and toxicological studies. Int J Nanomedicine 10:5459–
5473
Fidler IJ (1985) Immunomodulation of macrophages for cancer and antiviral therapy. Wiley , New
York
Fidler IJ (1988) Targeting of immunomodulators to mononuclear phagocytes for therapy of cancer.
Adv Drug Deliv Rev 2(1):69–106
Fozzard HA, Lee PJ, Lipkind GM (2005) Mechanism of local anesthetic drug action on
voltage-gated sodium channels. Curr Pharm Des 11(21):2671–2686
Franco-Cereceda A, Lundberg JM (1985) Calcitonin gene-related peptide (CGRP) and
capsaicin-induced stimulation of heart contractile rate and force. Naunyn Schmiedebergs
Arch Pharmacol 331(2–3):146–151
Franco-Cereceda A, Lundberg JM, Saria A, Schreibmayer W, Tritthart HA (1988) Calcitonin
gene-related peptide: release by capsaicin and prolongation of the action potential in the
guinea-pig heart. Acta Physiol Scand 132(2):181–190
Fraser SP, Grimes JA, Djamgoz MB (2000) Effects of voltage-gated ion channel modulators on rat
prostatic cancer cell proliferation: comparison of strongly and weakly metastatic cell lines.
Prostate 44(1):61–76
Friese MA, Fugger L (2005) Autoreactive CD8+ T cells in multiple sclerosis: a new target for
therapy? Brain 128(Pt 8):1747–1763
Fu M, Sun ZH, Zuo HC (2010) Neuroprotective effect of piperine on primarily cultured
hippocampal neurons. Biol Pharm Bull 33(4):598–603
Gadermaier E, Levin M, Flicker S, Ohlin M (2014) The human IgE repertoire. Int Arch Allergy
Immunol 163(2):77–91
Gasior M, Kleinrok Z, Czuczwar SJ (1995) Influence of BAY k-8644, a calcium channel agonist,
on the anticonvulsant activity of conventional anti-epileptics against electroconvulsions in
mice. Neuropharmacology 34(4):433–438
Gasparini C, Feldmann M (2012) NF-jB as a target for modulating inflammatory responses. Curr
Pharm Des 18(35):5735–5745
George K, Thomas NS, Malathi R (2019) Piperine blocks voltage gated K(+) current and inhibits
proliferation in androgen sensitive and insensitive human prostate cancer cell lines. Arch
Biochem Biophys 667:36–48
22 Piperine: Sources, Properties, Applications …
785