21.9.7 Anti-aging Properties
The extract of Boerhaavia diffusa can be served as diuretics, anti-convulsants,
opthalmic and anti-aging products (Rajpoot and Mishra 2011). The gall of
Terminalia chebula was tested for inhibitory activity against tyrosinase as well as
the proliferative and MMP-2 inhibition activity on early aging human skin
fibroblasts in order to evaluate their in vitro anti-aging activity and it resulted in a
potent tannin extract that could be used as anti-aging drug (Manosroi et al. 2010).
Phyllanthus emblica extracted tannins showed marked anti-aging and skin protection activity (Chaudhuri et al. 2007). The tannins, catechins, epigallocatechin
gallate, naringenin obtained from Cochlospermum vitifolium also possess anti-aging
potency due to its ability to inhibit collagenase, elastase, hyaluronidase enzymes
(German-Baez et al. 2017).
21.9.8 Other Therapeutic Activities of Tannins
Tannins from Mouriri pusa showed a good in-vivo anti-ulcer activity by giving
cyto-protective effects against gastric ulcers in rats (Vasconcelos et al. 2010).
Kaki-tannin is seen to have the ability in preventing the rise of total plasma
cholesterol, non-HDL cholesterol, triglycerides in type 2 diabetic mice fed high fat
diet. It also induces the genes which can metabolize cholesterol (Matsumoto and
Yokoyama 2012). Induction of immune response by stimulating interleukin 1
(IL-1) can be seen in case of different ellagitannin oligomers such as oenothein A
and B, camellin B, woodfordin C, D, E and F (Okuda and Ito 2011).
Some in-vivo and in-vitro assays had been done to check its effectiveness against
alzheimer’s disease and epilepsy (convulsion) and tannic acid was seen to inhibit
b-secretase activity via interfering with amyloid beta production and also it prevented cognitive impairment (Pal et al. 2008, 2009; Pal and Mazumder 2014; Gupta
et al. 2003; Pal and Nandi 2005; Mori et al. 2012). The hydrolysable tannins
Table 21.9 Anti-inflammatory property of different tannins
Tannin
Characteristics
Assay
type
Tannin from Terminalia
chebula
Keratinocyte and fibroblast proliferation mediated
wound healing property
In-vitro
Grape seed
proanthocyanidins
Amelioration of mitochondrial oxidative stress
Tannic acid
Crosslinks fibrous collagen and prevents collagen
matrix degradation
Corilagin
Prevents membrane breakdown of lung epithelial cell
and fibrosis
In-vivo
21 Tannins and Polyphenols Extracted from Natural Plants …
745
The extract of Boerhaavia diffusa can be served as diuretics, anti-convulsants,
opthalmic and anti-aging products (Rajpoot and Mishra 2011). The gall of
Terminalia chebula was tested for inhibitory activity against tyrosinase as well as
the proliferative and MMP-2 inhibition activity on early aging human skin
fibroblasts in order to evaluate their in vitro anti-aging activity and it resulted in a
potent tannin extract that could be used as anti-aging drug (Manosroi et al. 2010).
Phyllanthus emblica extracted tannins showed marked anti-aging and skin protection activity (Chaudhuri et al. 2007). The tannins, catechins, epigallocatechin
gallate, naringenin obtained from Cochlospermum vitifolium also possess anti-aging
potency due to its ability to inhibit collagenase, elastase, hyaluronidase enzymes
(German-Baez et al. 2017).
21.9.8 Other Therapeutic Activities of Tannins
Tannins from Mouriri pusa showed a good in-vivo anti-ulcer activity by giving
cyto-protective effects against gastric ulcers in rats (Vasconcelos et al. 2010).
Kaki-tannin is seen to have the ability in preventing the rise of total plasma
cholesterol, non-HDL cholesterol, triglycerides in type 2 diabetic mice fed high fat
diet. It also induces the genes which can metabolize cholesterol (Matsumoto and
Yokoyama 2012). Induction of immune response by stimulating interleukin 1
(IL-1) can be seen in case of different ellagitannin oligomers such as oenothein A
and B, camellin B, woodfordin C, D, E and F (Okuda and Ito 2011).
Some in-vivo and in-vitro assays had been done to check its effectiveness against
alzheimer’s disease and epilepsy (convulsion) and tannic acid was seen to inhibit
b-secretase activity via interfering with amyloid beta production and also it prevented cognitive impairment (Pal et al. 2008, 2009; Pal and Mazumder 2014; Gupta
et al. 2003; Pal and Nandi 2005; Mori et al. 2012). The hydrolysable tannins
Table 21.9 Anti-inflammatory property of different tannins
Tannin
Characteristics
Assay
type
Tannin from Terminalia
chebula
Keratinocyte and fibroblast proliferation mediated
wound healing property
In-vitro
Grape seed
proanthocyanidins
Amelioration of mitochondrial oxidative stress
Tannic acid
Crosslinks fibrous collagen and prevents collagen
matrix degradation
Corilagin
Prevents membrane breakdown of lung epithelial cell
and fibrosis
In-vivo
21 Tannins and Polyphenols Extracted from Natural Plants …
745