Table 21.6 In-vitro and in-vivo activities of tannins against cancer
Tannin
Characteristics
Assay
type
Geraniin and corilagin
Inhibits TNF-a
In vitro
Hydrolysable tannins from Eugenia
jambolana, catechin
Inhibits a-amylase
Procyanidin B1 and B2
Epidermal growth factor receptor
phosphorylation, inhibiting the growth of
human colon carcinoma cell line
Gallic acid from Blackberry,
raspberry, walnuts, chocolate, wine,
green tea and vinegar
RhoB regulation and AKT/GTPase
signalling down-regulation
Delphinidin
Prevents NF-jB pathway
Peonidin-3-glucoside
Prevents the invasion and metastasis of
lung cancer cells
Epigallocatechin gallate
Inhibits nicotine-induced lung cancer,
inhibits surviving, interferes with Wnt
pathway in gastric cancer, Akt, ERK and
p38MAPK signaling pathways in colon
cancer
Tenophyllanin A and alienanin B and
C, Epigallocatechin gallate
Skin tumour promotion by DMBA,
tetradecanoylphorbol-13-acetate,
teleocidin is inhibited
In vivo
Proanthocyanidins from Apple and
red wine
Azoxymethane induced colon carcinoma
prevention
Procyanidins hexamer from cocoa and
Japanese quince
Arrests G 2 /M cell cycle colorectal cancer
cells via Akt pathway and interferes with
Caco‐2 colon cancer cell
Ellagic acid
G 0 /G 1 cell cycle arrest in breast cancer
cell, androgen independent prostate
cancer suppression, inhibition of
MMP-9, caspase-dependent apoptosis of
prostate cancer cell line
Gallo tannin
ROS-dependent pro-apoptotic effects on
colon and prostate cancer cells
Gallic acid
down-regulation of MMP-2 and MMP-9
in prostate and cervical cancer cell line
Epigallocatechin gallate
Prevents angiogenesis and EMT, inhibits
androgen action in prostate cancer and
estrogen action in breast cancer
Anthocyanidins
Inhibits tumor growth in lung cancer cell
line, suppressing the growth of
HER2-positive tumor
742
S. Mal and D. Pal