Table 16.1
(continued)
Bioactivities
Gedunin/Derivatives
Experimental model
Efficacy
References
to achieve 80% parasitaemia
clearance
D6: 783 ng/mL
a
W2: 749 ng/mL
a
Omar et al.
(2003a)
In vitro antimalarial microdilution assay
against Plasmodium falciparum
chloroquine-sensitive clone W2 and
chloroquine-resistance clone D6
In vitro MTT assay for female Brugia
malayi
adult worm
D6: 556 ng/mL
a
W2: 473 ng/mL
a
7-Benzyloxygedunin
D6: 1828 ng/mL
a
W2: 1998 ng/mL
a
7-Hydroxygedunin
0.21
lg/mL
a
Photogedunin
In vitro MTT assay for female Brugia
malayi
microfilaria
2.23
lg/mL
a
Misra et al.
(2011),
Okhale et al.
(2012)
In vivo experimental model
intra-peritoneally inoculated with Brugia
malayi
adult worm
−70.0 ± 10.0%
b
changes in
worm recovery
Minimum inhibitory concentration
(MIC) against: Bacillus subtilis,
Staphylococcus aureus, Klebsiella
pneumonia, Escherichia coli
Bs: NA
Sa: NA
Kp: NA
Ec: NA
Antimicrobial
Gedunin
Minimum inhibitory concentration
(MIC) against: Bacillus subtilis,
Staphylococcus aureus, Klebsiella
pneumonia, Escherichia coli
Bs: NA
Sa: 2000
lg/mL
b
Kp: 1000
lg/mL
b
Ec: 2000
lg/mL
b
Okhale et al.
(2013),
Cespedes
et al. (2016)
7-deacetoxy-7a-hydroxygedunin
potassium salt
Minimum inhibitory concentration
(MIC) against: Bacillus subtilis,
Staphylococcus aureus, Klebsiella
pneumonia, Escherichia coli
Bs: 2000
lg/mL
b
Sa: NA
b
Kp: 1000
lg/mL
b
Ec: 2000
lg/mL
b
7-deacetoxy-7a-hydroxygedunin
In vitro bioassay with fall armyworm
larvae
39.0 ppm
b
with 48.3% larvae
survival
(continued)
16 An Overview of the Bioactivities of Gedunin
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