Table 16.1
(continued)
Bioactivities
Gedunin/Derivatives
Experimental model
Efficacy
References
chloroquine-sensitive clone D10 and
chloroquine-resistance clone W2
7-Ketogedunin
D6: 2500 ng/mL
a
W2: 900 ng/mL
a
Tetrahydrogedunin
D6: 133 ng/mL
a
W2: 39 ng/mL
a
21-Acetylgedunin
D6: 832 ng/mL
a
W2: 156 ng/mL
a
23-Acetylgedunin
D6: 10,000 ng/mL
a
W2: 2130 ng/mL
a
Hexahydrogedunin
D6: 2610 ng/mL
a
W2: 1280 ng/mL
a
7-Deacetylgedunin
D10: 5.14
± 1.23
a
W2: 3.29
± 0.59
a
In vivo Plamodium berghei-infected
experimental model
50 mg kg
−1
day
−1b
to
achieve 67.5% parasitaemia
clearance
50 mg kg
−1
day
−1b
synergize with
25 mg kg
−1
day
−1
dillapiol
to achieve 80.7%
parasitaemia clearance
Omar et al.
(2003b)
7-Methoxygedunin
In vivo Plamodium berghei-infected
experimental model
In vitro antimalarial microdilution assay
against Plasmodium falciparum
chloroquine-sensitive clone W2 and
chloroquine-resistance clone D6
50 mg kg
−1
day
−1b
to
achieve 67% parasitaemia
clearance
50 mg kg
−1
day
−1b
synergize with
25 mg kg
−1
day
−1
dillapiol
Omar et al.
(2003a)
(continued)
572
Y. S. Ong et al.