Table 16.1
(continued)
Bioactivities
Gedunin/Derivatives
Experimental model
Efficacy
References
In vitro antimalarial microdilution assay
against Plasmodium falciparum
chloroquine-sensitive clone W2 and
chloroquine-resistance clone D6
D6: 306 ng/mL
a
W2: 315 ng/mL
a
Omar et al.
(2003a)
In vitro human erythrocyte infected with
Plasmodium falciparum
chloroquine-sensitive clone D10 and
chloroquine-resistance clone W2
D10: 1.66
± 0.37
a
W2: 1.31
± 0.42
a
Chianese
et al. (2010)
In vitro MTT assay for female Brugia
malayi
adult worm
0.24
lM
a
Misra et al.
(2011)
In vitro MTT assay for female Brugia
malayi
microfilaria
2.03
lM
a
MacKinnon
et al. (1997),
Misra et al.
(2011)
In vivo experimental model
intra-peritonealy inoculated with Brugia
malayi
adult worm
−80.0 ± 10.0%
b
changes in
worm recovery
In vitro antimalarial microdilution assay
against Plasmodium falciparum
chloroquine-sensitive clone W2 and
chloroquine-resistance clone D6
D6: 39 ng/mL
a
W2: 20 ng/mL
a
In vitro antimalarial microdilution assay
against Plasmodium falciparum
chloroquine-sensitive clone W2 and
chloroquine-resistance clone D6
D6: >10,000 ng/mL
a
W2: 840 ng/mL
a
MacKinnon
et al. (1997),
Chianese
et al. (2010)
1,2-Dihydrogegunin
In vitro antimalarial microdilution assay
against Plasmodium falciparum
chloroquine-sensitive clone W2 and
chloroquine-resistance clone D6
In vitro human erythrocyte infected with
Plasmodium falciparum
D6: 2580 ng/mL
a
W2: 980 ng/mL
a
1,2-Epoxygedunin
D6: 4210 ng/mL
a
W2: 2440 ng/mL
a
1,2-Dihydro-3b-gedunol
D6: > 10,000 ng/mL
a
W2: > 10,000 ng/mL
a
(continued)
16 An Overview of the Bioactivities of Gedunin
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