Table 16.1
(continued)
Bioactivities
Gedunin/Derivatives
Experimental model
Efficacy
References
Cryoprotective
Gedunin
Experimental rat (in vivo)
56.86
lg/mL
a
Lakshmi
et al. (2010)
Primary neuronal and astrocyte cells
0–24
lM
b
Smirnova
et al. (2011)
Experimental rat (in vivo)
66.54
lg/mL
a
Lakshmi
et al. (2010)
Photogedunin
Primary rat hippocampal neurons
500 nM
b
Jang et al.
(2010)
Deoxygedunin
Neuroblastoma cell line SK-N-SH
24.03
c
Zhang et al.
(2009)
Neuroblastoma cell line SK-N-SH
12.77
c
Zhang et al.
(2009)
Deacetylgedunin
Neuroblastoma cell line SK-N-SH
6.02
c
Zhang et al.
(2009)
Deacetoxy-7-oxogedunin
In vivo articular inflammation
experimental model
Pretreatment: 0.005–5 mg/
kg
b
Post-treatment: 0.05 mg/kg
b
Conte et al.
(2015)
Anti-neurological
Gedunin
Inhibit NF-jB activation
3.5–7.5
lM
Tom et al.
(2019)
Neuro-2a cells
20
lM
Yang et al.
(2019)
Anti-inflammation
Gedunin
TPA-induced ear edema inflammation in
Mice
0.16
d
Akihisa et al.
(2009)
Inhibited NLRP3 expression in vivo
0.5 mg/kg
Borges et al.
(2017)
(continued)
16 An Overview of the Bioactivities of Gedunin
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