200 µg bath of 228 did not exhibit any kind of activity in uterine and intestinal
contractions. Higher nervous activity was screened in the rabbit, by injecting 30 µg/
kg of 228. The treated animal did not exhibit any kind of immediate effect. After
30 min, it became quiet, showed a stupor attitude. Neuroleptic properties of 228
were identified with the help of spontaneous motility tests in mice. Intraperitoneal
administration of 500 µg/kg of the drug resulted in somnolence and a state of
apprehension after 30–40 min.
14.3.5.2 Psychopharmacological Effects
Bhatt acharyaa et al. evaluated the psychopharmacological effects of A. venenataderived alkaloids (228, venenatine (229) and echitovenidine (230), Fig. 14.46) by
various methods (Bhattacharya et al. 1975). Compound 228 (1 mg/kg, i.p.) produced signs of central excitation such as piloerection, irritability, enhanced locomotor activity, increased startle response, and exophthalmos. A reduction in motor
N
H
N
H
O
O
HO
O
Alstiboonine (227)
Fig. 14.44 Chemical
structure of alstiboonine (227)
Alstovenine (228)
O
HN
O
O
HO
N
Fig. 14.45 Chemical
structure of alstovenine (228)
Venenatine (229)
O
HN
O
O
HO
N
N
N
H
O
O
O
O
Echitovenidine (230)
Fig. 14.46 Chemical structures of venenatine and echitovenidine (229 and 230)
506
A. T. Paul et al.