(IC 50 values = 36.0 and 48.0 µg/mL) than the positive control, Vit. C (IC 50 of
49.0 µg/mL). Antimicrobial activity was performed against E. coli. Quercetin-3-O[a-L-rhamnopyranosyl (1 ! 2)-b-D-glucopyranoside] 225) and Quercetin-3-O[a-L-rhamnopyranosyl (1 ! 2)-b-D-glucopyranoside] (226) exhibited a potential
antibacterial activity with a MIC values of 1.77 µg/mL and 1.92 µg/mL,
respectively.
14.3.4.6 Cytotoxic Activities
Olaoye S. et al. isolated a cytotoxic indole alkaloid, Alstiboonine (227, Fig. 14.44),
from aqueous methanolic extract of A. boonei stem bark and confirmed its cytotoxic
activities through brine shrimp lethality assay (Balogun et al. 2016). The titled
compound exhibited a potent LD 50 value (39.72 µg/mL) and was claimed as a
cytotoxic phytochemical.
14.3.5 Phytochemistry and Pharmacological Activities
of A. Venenata
14.3.5.1 Hypertensive and Neuroleptic Properties
P. K Dey evaluated various pharmacological activities of alstovenine (228,
Fig. 14.45), an alkaloid from A. venenata (Dey 1965). The hypertensive activity of
228 was screened in chloralosed cat, and the desired pharmacological activity was
observed with a concentration of 25–30 µg/kg of body weight. Further, a 100–
Rutin (219)
O
O
O
O
O
O
O H
OH
HO
OH
HO
HO
OH
HO
OH
OH
Quercetin robinobioside (220)
O
O
O
O
O
O
O H
OH
HO
OH
HO
HO
OH
HO
OH
OH
Kaempferol-3-O-rutinoside (221)
O
O
O
O
O
O
O H
OH
HO
HO
HO
OH
HO
OH
OH
Kaempferol-3-O-robinobioside (222)
O
O
O
O
O
O
O H
OH
HO
HO
HO
OH
HO
OH
OH
OH
O
O
O
O
O H
OH
HO
OH
HO
HO
O
O
HO
OH
OH
OH
O
O
O
O
O H
OH
HO
OH
HO
OH
O
O
OH
HO
HO
OH
O
O
O
O
O H
OH
HO
HO
HO
O
O
HO
OH
OH
OH
O
O
O
O
O H
OH
HO
OH
HO
OH
O
O
OH
HO
HO
Quercetin-3-O-[ -L-rhamnopyranosyl
(1 2) -Dgalactopyranoside] (226)
Quercetin-3-O-[ -L-rhamnopyranosyl
(1 2) -Dglucopyranoside] (225)
Quercetin-3-O-[ -L-rhamnopyranosyl
(1 4) -Dglucopyranoside] (223)
Kaempferol-3-O-[ -L-rhamnopyranosyl
(1 4) -Dglucopyranoside] (224)
Fig. 14.43 Chemical structures of various flavonoid glycosides from A. boonei (219–226)
14 Pharmaceutical Application of Bio-actives …
505
49.0 µg/mL). Antimicrobial activity was performed against E. coli. Quercetin-3-O[a-L-rhamnopyranosyl (1 ! 2)-b-D-glucopyranoside] 225) and Quercetin-3-O[a-L-rhamnopyranosyl (1 ! 2)-b-D-glucopyranoside] (226) exhibited a potential
antibacterial activity with a MIC values of 1.77 µg/mL and 1.92 µg/mL,
respectively.
14.3.4.6 Cytotoxic Activities
Olaoye S. et al. isolated a cytotoxic indole alkaloid, Alstiboonine (227, Fig. 14.44),
from aqueous methanolic extract of A. boonei stem bark and confirmed its cytotoxic
activities through brine shrimp lethality assay (Balogun et al. 2016). The titled
compound exhibited a potent LD 50 value (39.72 µg/mL) and was claimed as a
cytotoxic phytochemical.
14.3.5 Phytochemistry and Pharmacological Activities
of A. Venenata
14.3.5.1 Hypertensive and Neuroleptic Properties
P. K Dey evaluated various pharmacological activities of alstovenine (228,
Fig. 14.45), an alkaloid from A. venenata (Dey 1965). The hypertensive activity of
228 was screened in chloralosed cat, and the desired pharmacological activity was
observed with a concentration of 25–30 µg/kg of body weight. Further, a 100–
Rutin (219)
O
O
O
O
O
O
O H
OH
HO
OH
HO
HO
OH
HO
OH
OH
Quercetin robinobioside (220)
O
O
O
O
O
O
O H
OH
HO
OH
HO
HO
OH
HO
OH
OH
Kaempferol-3-O-rutinoside (221)
O
O
O
O
O
O
O H
OH
HO
HO
HO
OH
HO
OH
OH
Kaempferol-3-O-robinobioside (222)
O
O
O
O
O
O
O H
OH
HO
HO
HO
OH
HO
OH
OH
OH
O
O
O
O
O H
OH
HO
OH
HO
HO
O
O
HO
OH
OH
OH
O
O
O
O
O H
OH
HO
OH
HO
OH
O
O
OH
HO
HO
OH
O
O
O
O
O H
OH
HO
HO
HO
O
O
HO
OH
OH
OH
O
O
O
O
O H
OH
HO
OH
HO
OH
O
O
OH
HO
HO
Quercetin-3-O-[ -L-rhamnopyranosyl
(1 2) -Dgalactopyranoside] (226)
Quercetin-3-O-[ -L-rhamnopyranosyl
(1 2) -Dglucopyranoside] (225)
Quercetin-3-O-[ -L-rhamnopyranosyl
(1 4) -Dglucopyranoside] (223)
Kaempferol-3-O-[ -L-rhamnopyranosyl
(1 4) -Dglucopyranoside] (224)
Fig. 14.43 Chemical structures of various flavonoid glycosides from A. boonei (219–226)
14 Pharmaceutical Application of Bio-actives …
505