Table 14.12 Cytotoxic
effects of various alkaloids
from A. macrophylla and
vinblastine sulfate against
various cell lines
Compound
Cell lines
IC 50 values (µM for the compounds and nM
for vinblastine)
114
115
116
Vinblastine sulfate
MOR-P
6.3
4.6
2.3
3.1
COR-L23
4.1
5.3
2.9
0.9
BF
21.9
8.1
8.5
>100
StMl la
3.3
2.9
2.4
1.7
Caki-2
4.6
7.3
2.9
1.9
MCF-7
2.4
1.9
3.4
0.5
Ls 174T
2.4
1.8
1.9
0.8
MOR-P-adenocarcinoma, COR-L23 human lung cancer cell
lines; BF-normal human breast fibroblast cell line; StMl
la-melanoma; Caki-2-renal cell carcinoma; Ls174T-colon
adenocarcinoma
Talcarpine (118)
O
N
N
O
Pleiocarpamine (119)
N
N
O
O
Alstoumerine (120)
N
N
OH
OH
N
H
N
OH
H
H
H
20-Epi-antirhine (121)
Alstonerine (122), R = H
Alstophylline (123), R = OMe
O
O
N
N
R
Macralstonine (124); R = OH
O-Methyl macralstonine (125); R = OMe
O
O
N
N
O
R
N
N
O
Alstomacrophylline (126)
O
O
N
N
O O
N
N
O
Alstomacroline (128)
N
OH
O
O
N
O
OH
N
N
N
O
N
N
N
O
H
H
H 3 COOC
H
H
Villalstonine N
b -oxide (127)
O
Fig. 14.29 Chemical structures of various alkaloids from A. macrophylla (118–128)
14 Pharmaceutical Application of Bio-actives …
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