Table 13.3
(continued)
S.
No.
Cell lines
Effect and mechanism
IC
50
(µM/l)/dose
Reference
8
Human prostate cancer DU145
Antiproliferative agent,
"apoptosis, "caspase-3, #
DWm, cell cycle arrest at G0/G1 phase
DU145:84.39
lM
Khan et al. (2017)
9
Human gastric adenocarcinoma AGS
cells
┴proliferation, "apoptosis,, #GSH levels,,
"Bax,
"caspase-3, "caspase-9, # Bcl-2,
AGS:82.57
± 5.58
lM
G
ünes-Bayir et al.
(2017)
10
Prostate cancer cell lines DU145
Prostate cancer cell lines: PC3
Antiproliferative effect,
#MMP-2, #p-Akt, and
#p-ERK1/2, ┴migration, ┴invasion
DU145: 498.3
± 12.2
PC3: 430.6
± 21.9
Luo et al. (2016)
11
Human T lymphocyte Cells: Jurkat
Inflection of T cell activity by
# IL-2,
# IFN-c,
"AP-1 and
"NFAT2
50
lg/ml (Dose)
Gholijani et al.
(2015)
12
Human acute promyelocytic leukemia
cell line (HL-60), and (immortalized
human T cell lymphocyte cell line
(Jurkat)
Induced apoptosis,
"caspase-3, "Bax, # Bcl-2,
#
DWm
HL-60: 100
lM
Jurkat: 50
lM
Bhakkiyalakshmi
et al. (2016)
13
Human oral squamous cell carcinoma:
Tca-8113
┴Proliferation, "apoptosis, cell cycle arrest at
G1/S phase,
#cyclin D1,
#CDK4, "Bax/Bcl-2
ratio
0-80
lM (Doses)
Dai et al. (2016)
14
Human hepatomacell lines: HepG2
┴Proliferation, "apoptosis, cell cycle arrest at
G1/S phase
HepG2: 425
lM
Melušová et al.
(2014)
15
Murine melanoma cell line:B16(F10)
┴tumer growth
B16F10: 120
± 15
lM
He et al. (1997)
16
N2a neuroblastoma cells
"cytotoxicity, ┴proliferation, anticancer activity
>200 mg
Aydin et al. (2014)
17
MDA-MB 231
┴proliferation, induced morphological changes,
"apoptosis
MDA-MB 231: 100
Arunasree (2010)
18
Human hepatocellular carcinoma cell
line HepG2
Induced anti-proliferation and
"apoptosis,
"caspase-3, # Bcl-2,
"cleavage of PARP,
#
p-ERK1/2,
"phosphorylation of p38
HepG2: 0.4 mM/ml
Yin et al. (2012)
19
Human non-small cell lung cancer
cell line: A549
Anticancerogenic activity
100–1000
lM
Koparal and
Zeytinoglu (2003)
(continued)
13 Carvacrol (Origanum vulgare): Therapeutic Properties …
449
(continued)
S.
No.
Cell lines
Effect and mechanism
IC
50
(µM/l)/dose
Reference
8
Human prostate cancer DU145
Antiproliferative agent,
"apoptosis, "caspase-3, #
DWm, cell cycle arrest at G0/G1 phase
DU145:84.39
lM
Khan et al. (2017)
9
Human gastric adenocarcinoma AGS
cells
┴proliferation, "apoptosis,, #GSH levels,,
"Bax,
"caspase-3, "caspase-9, # Bcl-2,
AGS:82.57
± 5.58
lM
G
ünes-Bayir et al.
(2017)
10
Prostate cancer cell lines DU145
Prostate cancer cell lines: PC3
Antiproliferative effect,
#MMP-2, #p-Akt, and
#p-ERK1/2, ┴migration, ┴invasion
DU145: 498.3
± 12.2
PC3: 430.6
± 21.9
Luo et al. (2016)
11
Human T lymphocyte Cells: Jurkat
Inflection of T cell activity by
# IL-2,
# IFN-c,
"AP-1 and
"NFAT2
50
lg/ml (Dose)
Gholijani et al.
(2015)
12
Human acute promyelocytic leukemia
cell line (HL-60), and (immortalized
human T cell lymphocyte cell line
(Jurkat)
Induced apoptosis,
"caspase-3, "Bax, # Bcl-2,
#
DWm
HL-60: 100
lM
Jurkat: 50
lM
Bhakkiyalakshmi
et al. (2016)
13
Human oral squamous cell carcinoma:
Tca-8113
┴Proliferation, "apoptosis, cell cycle arrest at
G1/S phase,
#cyclin D1,
#CDK4, "Bax/Bcl-2
ratio
0-80
lM (Doses)
Dai et al. (2016)
14
Human hepatomacell lines: HepG2
┴Proliferation, "apoptosis, cell cycle arrest at
G1/S phase
HepG2: 425
lM
Melušová et al.
(2014)
15
Murine melanoma cell line:B16(F10)
┴tumer growth
B16F10: 120
± 15
lM
He et al. (1997)
16
N2a neuroblastoma cells
"cytotoxicity, ┴proliferation, anticancer activity
>200 mg
Aydin et al. (2014)
17
MDA-MB 231
┴proliferation, induced morphological changes,
"apoptosis
MDA-MB 231: 100
Arunasree (2010)
18
Human hepatocellular carcinoma cell
line HepG2
Induced anti-proliferation and
"apoptosis,
"caspase-3, # Bcl-2,
"cleavage of PARP,
#
p-ERK1/2,
"phosphorylation of p38
HepG2: 0.4 mM/ml
Yin et al. (2012)
19
Human non-small cell lung cancer
cell line: A549
Anticancerogenic activity
100–1000
lM
Koparal and
Zeytinoglu (2003)
(continued)
13 Carvacrol (Origanum vulgare): Therapeutic Properties …
449