13.7 Acute Toxicity of Carvacrol
Data on carvacrol toxicology is limited. Various toxicology studies have been done
in different animal models. Andre et al. (2016) investigated the acute toxicity study
in carvacrol administered through esophageal gavage route in Swiss albino mice.
The result revealed that depression occurs within 10 min of carvacrol administration, coma, and death of animals within 1 h to 3 days. Administration of the
essential oil carvacrol in rabbits, rats, and dogs exhibited the non-toxic nature,
although the detailed information was not documented (Budavari 1989; Livingston
1921; Andersen 2006; Ghorani et al. 2019). But some reports showed the toxic
behavior of the test drug carvacrol in Osborne-Mendel rats and mice, where
depression, ataxia, decreased spontaneous motor activity, somnolence, coma, and
death were observed (Jenner et al. 1964; Viana et al. 1981) Detail reports of animal
acute toxicity studies have been enlisted in Table 13.1. However, the likely toxicity
impacts of carvacrol on humans have not been reported till date.
Fig. 13.3 Metabolic pathway of carvacrol
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Data on carvacrol toxicology is limited. Various toxicology studies have been done
in different animal models. Andre et al. (2016) investigated the acute toxicity study
in carvacrol administered through esophageal gavage route in Swiss albino mice.
The result revealed that depression occurs within 10 min of carvacrol administration, coma, and death of animals within 1 h to 3 days. Administration of the
essential oil carvacrol in rabbits, rats, and dogs exhibited the non-toxic nature,
although the detailed information was not documented (Budavari 1989; Livingston
1921; Andersen 2006; Ghorani et al. 2019). But some reports showed the toxic
behavior of the test drug carvacrol in Osborne-Mendel rats and mice, where
depression, ataxia, decreased spontaneous motor activity, somnolence, coma, and
death were observed (Jenner et al. 1964; Viana et al. 1981) Detail reports of animal
acute toxicity studies have been enlisted in Table 13.1. However, the likely toxicity
impacts of carvacrol on humans have not been reported till date.
Fig. 13.3 Metabolic pathway of carvacrol
13 Carvacrol (Origanum vulgare): Therapeutic Properties …
443