zone 12.6 mm of killing Proteus vulgaris strain (El-Refai et al. 2018). In the next
series of modified silver NPs, Vimala et al. (2011) prepared curcumin fabricated
chitosan polyvinyl alcohol silver NPs and reviewed its antimicrobial activity on
some wound born bacteria and fungi, i.e., Escherichia coli, pseudomonas,
Table 12.4 Clinical trials of phytoconstituents of turmeric and garlic
Clinical trial id Disease
Drug
Phase
Status
Period
Sponsored by
Turmeric
NCT02018328 Helicobacter
pylori
infection
Curcumin
Not
applicable
Unknown
Jan 2014–
Dec 2015
Gingold Belfer
Rachel
NCT04012424 Acute
Pulpitis
Curcumin
Not
applicable
Not yet
required
Aug 2019–
Nov 2020
Cairo University
NCT03790605 Periodontitis
Curcumin
Phase III
Recruiting Sep 2019–
Dec 2020
KLE Society’s
Institute of
Dental Sciences
NCT01035580 Uterine
Cervical
Dysplasia
Curcumin
Phase I
Completed Jan 2010–
Jan 2012
Emory
University
NCT03746158 Metabolites
Gut
Microbiota
Curcumin
Not
applicable
Not yet
required
Dec 2018–
Apr 2019
University of
Massachusetts,
Amherst
NCT03141918 HIV
infection
Curcumin
Not
applicable
Completed Sept 2017–
Dec 2017
Universidade
Federal do Rio
Grande do Norte
NCT03016039 Wound
infection in
female
Curcumin
Not
applicable
Unknown
Jan 2017–
Oct 2017
Meir Medical
Centre
NCT04071106 Psoriasis
Turmeric
extract
Phase II
Not yet
required
19-Sep
Zagazig
University
Turmeric
extract in
olive oil
Phase III
NCT02152475 Oral
disinfection
Curcumin
mouthwash
Phase I
Completed 13-May
University of
Sao Paulo
NCT02442453 Chronic
Periodontitis
Curenext
gel
Phase IV
Completed 14-Jan
Tatyasaheb Kore
Dental College
NCT04032132 Periodontitis
Curcumin
paste
Phase IV
Completed 16-Aug
Ain Shams
University
Garlic
NCT03795636 Intracanal
irrigant
Garlic
Not
applicable
Completed Oct 2016–
Aug 2018
Minia University
NCT01198223 Chronic oral
candidiasis
Garlic,
nystatin
Phase II
Completed July 2010–
Oct 2010
Qazvin
University of
Medical
Sciences
NCT03492723 Periodontitis
Garlic
Not
applicable
Recruiting Apr 2018–
Apr 2020
Hadassah
Medical
Organization
12 Antimicrobial Application Potential …
425
series of modified silver NPs, Vimala et al. (2011) prepared curcumin fabricated
chitosan polyvinyl alcohol silver NPs and reviewed its antimicrobial activity on
some wound born bacteria and fungi, i.e., Escherichia coli, pseudomonas,
Table 12.4 Clinical trials of phytoconstituents of turmeric and garlic
Clinical trial id Disease
Drug
Phase
Status
Period
Sponsored by
Turmeric
NCT02018328 Helicobacter
pylori
infection
Curcumin
Not
applicable
Unknown
Jan 2014–
Dec 2015
Gingold Belfer
Rachel
NCT04012424 Acute
Pulpitis
Curcumin
Not
applicable
Not yet
required
Aug 2019–
Nov 2020
Cairo University
NCT03790605 Periodontitis
Curcumin
Phase III
Recruiting Sep 2019–
Dec 2020
KLE Society’s
Institute of
Dental Sciences
NCT01035580 Uterine
Cervical
Dysplasia
Curcumin
Phase I
Completed Jan 2010–
Jan 2012
Emory
University
NCT03746158 Metabolites
Gut
Microbiota
Curcumin
Not
applicable
Not yet
required
Dec 2018–
Apr 2019
University of
Massachusetts,
Amherst
NCT03141918 HIV
infection
Curcumin
Not
applicable
Completed Sept 2017–
Dec 2017
Universidade
Federal do Rio
Grande do Norte
NCT03016039 Wound
infection in
female
Curcumin
Not
applicable
Unknown
Jan 2017–
Oct 2017
Meir Medical
Centre
NCT04071106 Psoriasis
Turmeric
extract
Phase II
Not yet
required
19-Sep
Zagazig
University
Turmeric
extract in
olive oil
Phase III
NCT02152475 Oral
disinfection
Curcumin
mouthwash
Phase I
Completed 13-May
University of
Sao Paulo
NCT02442453 Chronic
Periodontitis
Curenext
gel
Phase IV
Completed 14-Jan
Tatyasaheb Kore
Dental College
NCT04032132 Periodontitis
Curcumin
paste
Phase IV
Completed 16-Aug
Ain Shams
University
Garlic
NCT03795636 Intracanal
irrigant
Garlic
Not
applicable
Completed Oct 2016–
Aug 2018
Minia University
NCT01198223 Chronic oral
candidiasis
Garlic,
nystatin
Phase II
Completed July 2010–
Oct 2010
Qazvin
University of
Medical
Sciences
NCT03492723 Periodontitis
Garlic
Not
applicable
Recruiting Apr 2018–
Apr 2020
Hadassah
Medical
Organization
12 Antimicrobial Application Potential …
425