Murça TM, Moraes PL, Capuruço CA, Santos SH, Melo MB, Santos RA, Ferreira AJ (2012) Oral
administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced
cardiac dysfunction. Regul Pept 177:107–115
Nair LS, Laurencin CT (2007) Biodegradable polymers as biomaterials. Prog Polym Sci 32:762–798
Narasimhamurthy K, Viswanatha S, Ramesh BS (1999) Acute and subchronic toxicity assessment
of debitterized fenugreek powder in the mouse and rat. Food Chem Toxicol 37:831–838
Nayak AK, Pal D (2014) Trigonella foenum-graecum L. seed mucilage-gellan mucoadhesive
beads for controlled release of metformin HCl. Carbohydr Polym 107:31–40
Nayak AK, Pal D, Das S (2013a) Calcium pectinate-fenugreek seed mucilage mucoadhesive beads
for controlled delivery of metformin HCl. Carbohydr Polym 96:349–357
Nayak AK, Pal D, Pradhan J, Ghorai T (2012) The potential of Trigonella foenum-graecum L.
seed mucilage as suspending agent. Ind J Pharm Educ Res 46:312–317
Nayak AK, Pal D, Pradhan J, Hasnain MS (2013b) Fenugreek seed mucilage-alginate
mucoadhesive beads of metformin HCl: Design, optimization and evaluation. Int J Biol
Macromol 54:144–154
Nokhodchi A, Nazemiyeh H, Khodaparast A, Sorkh-Shahan T, Valizadeh H, Ford JL (2008) An
in vitro evaluation of fenugreek mucilage as a potential excipient for oral controlled-release
matrix tablet. Drug Dev Ind Pharm 34:323–329
Opdyke DL (1978) Fenugreek absolute. Food Chem Toxicol 16:13–22
Ouzir M, El Bairi K, Amzazi S (2016) Toxicological properties of fenugreek (Trigonella foenum
graecum). Food Chem Toxicol 96:145–154
Park JH, Saravanakumar G, Kim K, Kwon IC (2010) Targeted delivery of low molecular drugs
using chitosan and its derivatives. Adv Drug Deliv Rev 62:28–41
Pathak D, Kumar P, Kuppusamy G, Gupta A, Kamble B, Wadhwani A (2014) Physicochemical
characterization and toxicological evaluation of plant-based anionic polymers and their
nanoparticulated system for ocular delivery. Nanotoxicology 8:843–855
Pavelić Ž, Škalko-Basnet N, Schubert R (2001) Liposomal gels for vaginal drug delivery. Int J
Pharm 219:139–149
Pincus T, Marcum SB, Callahan LF (1992) Longterm drug therapy for rheumatoid arthritis in
seven rheumatology private practices: II Second line drugs and prednisone. J Rheumatol
19:1885–1894
Pradeep SR, Srinivasan K (2017) Amelioration of hyperglycemia and associated metabolic
abnormalities by a combination of fenugreek (Trigonella foenum-graecum) seeds and onion
(Allium cepa) in experimental diabetes. J Basic Clin Physiol Pharmacol 28:493–505
Pradeep SR, Srinivasan K (2018) Alleviation of cardiac damage by dietary fenugreek (Trigonella
foenum-graecum) seeds is potentiated by onion (Allium cepa) in experimental diabetic rats via
blocking renin-angiotensin system. Cardiovasc Toxicol 18:221–231
Prajapati VD, Jani GK, Moradiya NG, Randeria NP, Maheriya PM, Nagar BJ (2014) Locust bean
gum in the development of sustained release mucoadhesive macromolecules of aceclofenac.
Carbohydr Polym 113:138–148
Prajapati VD, Jani GK, Moradiya NG, Randeria NP (2013a) Pharmaceutical applications of
various natural gums, mucilages and their modified forms. Carbohydr Polym 92:1685–1699
Prajapati VD, Jani GK, Moradiya NG, Randeria NP, Nagar BJ, Naikwadi NN, Variya BC (2013b)
Galactomannan: a versatile biodegradable seed polysaccharide. Int J Biol Macromol 60:83–92
Preet A, Gupta BL, Siddiqui MR, Yadava PK, Baquer NZ (2005) Restoration of ultrastructural and
biochemical changes in alloxan-induced diabetic rat sciatic nerve on treatment with Na 3 VO 4
and Trigonella—a promising antidiabetic agent. Mol Cell Biochem 278:21–31
Puttewar TY, Kshirsagar MD, Chandewar AV, Chikhale RV (2010) Formulation and evaluation of
orodispersible tablet of taste masked doxylamine succinate using ion exchange resin. J King
Saud Univ Sci 22:229–240
Raghuwanshi N, Kumari P, Srivastava AK, Vashisth P, Yadav TC, Prasad R, Pruthi V (2017)
Synergistic effects of Woodfordia fruticosa gold nanoparticles in preventing microbial
adhesion and accelerating wound healing in Wistar albino rats in vivo. Mater Sci Eng C Mater
Biol Appl 80:252–262
406
P. Mishra et al.
administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced
cardiac dysfunction. Regul Pept 177:107–115
Nair LS, Laurencin CT (2007) Biodegradable polymers as biomaterials. Prog Polym Sci 32:762–798
Narasimhamurthy K, Viswanatha S, Ramesh BS (1999) Acute and subchronic toxicity assessment
of debitterized fenugreek powder in the mouse and rat. Food Chem Toxicol 37:831–838
Nayak AK, Pal D (2014) Trigonella foenum-graecum L. seed mucilage-gellan mucoadhesive
beads for controlled release of metformin HCl. Carbohydr Polym 107:31–40
Nayak AK, Pal D, Das S (2013a) Calcium pectinate-fenugreek seed mucilage mucoadhesive beads
for controlled delivery of metformin HCl. Carbohydr Polym 96:349–357
Nayak AK, Pal D, Pradhan J, Ghorai T (2012) The potential of Trigonella foenum-graecum L.
seed mucilage as suspending agent. Ind J Pharm Educ Res 46:312–317
Nayak AK, Pal D, Pradhan J, Hasnain MS (2013b) Fenugreek seed mucilage-alginate
mucoadhesive beads of metformin HCl: Design, optimization and evaluation. Int J Biol
Macromol 54:144–154
Nokhodchi A, Nazemiyeh H, Khodaparast A, Sorkh-Shahan T, Valizadeh H, Ford JL (2008) An
in vitro evaluation of fenugreek mucilage as a potential excipient for oral controlled-release
matrix tablet. Drug Dev Ind Pharm 34:323–329
Opdyke DL (1978) Fenugreek absolute. Food Chem Toxicol 16:13–22
Ouzir M, El Bairi K, Amzazi S (2016) Toxicological properties of fenugreek (Trigonella foenum
graecum). Food Chem Toxicol 96:145–154
Park JH, Saravanakumar G, Kim K, Kwon IC (2010) Targeted delivery of low molecular drugs
using chitosan and its derivatives. Adv Drug Deliv Rev 62:28–41
Pathak D, Kumar P, Kuppusamy G, Gupta A, Kamble B, Wadhwani A (2014) Physicochemical
characterization and toxicological evaluation of plant-based anionic polymers and their
nanoparticulated system for ocular delivery. Nanotoxicology 8:843–855
Pavelić Ž, Škalko-Basnet N, Schubert R (2001) Liposomal gels for vaginal drug delivery. Int J
Pharm 219:139–149
Pincus T, Marcum SB, Callahan LF (1992) Longterm drug therapy for rheumatoid arthritis in
seven rheumatology private practices: II Second line drugs and prednisone. J Rheumatol
19:1885–1894
Pradeep SR, Srinivasan K (2017) Amelioration of hyperglycemia and associated metabolic
abnormalities by a combination of fenugreek (Trigonella foenum-graecum) seeds and onion
(Allium cepa) in experimental diabetes. J Basic Clin Physiol Pharmacol 28:493–505
Pradeep SR, Srinivasan K (2018) Alleviation of cardiac damage by dietary fenugreek (Trigonella
foenum-graecum) seeds is potentiated by onion (Allium cepa) in experimental diabetic rats via
blocking renin-angiotensin system. Cardiovasc Toxicol 18:221–231
Prajapati VD, Jani GK, Moradiya NG, Randeria NP, Maheriya PM, Nagar BJ (2014) Locust bean
gum in the development of sustained release mucoadhesive macromolecules of aceclofenac.
Carbohydr Polym 113:138–148
Prajapati VD, Jani GK, Moradiya NG, Randeria NP (2013a) Pharmaceutical applications of
various natural gums, mucilages and their modified forms. Carbohydr Polym 92:1685–1699
Prajapati VD, Jani GK, Moradiya NG, Randeria NP, Nagar BJ, Naikwadi NN, Variya BC (2013b)
Galactomannan: a versatile biodegradable seed polysaccharide. Int J Biol Macromol 60:83–92
Preet A, Gupta BL, Siddiqui MR, Yadava PK, Baquer NZ (2005) Restoration of ultrastructural and
biochemical changes in alloxan-induced diabetic rat sciatic nerve on treatment with Na 3 VO 4
and Trigonella—a promising antidiabetic agent. Mol Cell Biochem 278:21–31
Puttewar TY, Kshirsagar MD, Chandewar AV, Chikhale RV (2010) Formulation and evaluation of
orodispersible tablet of taste masked doxylamine succinate using ion exchange resin. J King
Saud Univ Sci 22:229–240
Raghuwanshi N, Kumari P, Srivastava AK, Vashisth P, Yadav TC, Prasad R, Pruthi V (2017)
Synergistic effects of Woodfordia fruticosa gold nanoparticles in preventing microbial
adhesion and accelerating wound healing in Wistar albino rats in vivo. Mater Sci Eng C Mater
Biol Appl 80:252–262
406
P. Mishra et al.