Ramesha BT, Amna T, Ravikanth G, Gunaga RP, Vasudeva R, Ganeshaiah KN, Shaanker RU,
Khajuria RK, Puri SC, Qazi GN (2008) Prospecting for camptothecines from Nothapodytes
nimmoniana in the Western Ghats, south India: identification of high-yielding sources of
campthecin and new families of camptothecines. J Chromatogr Sci 46:362–368
Ravichandra V, Ramesh C, Swamy MK, Purushotham B, Rudramurthy GR (2018) Anticancer plants:
chemistry, pharmacology, and potential applications. In: Akhtar MS, Swamy MK
(eds) Anticancer plants: properties and application, vol 1. Springer Nature, Singapore, pp 485–515
Raveendran VV (2015) Camptothecin-discovery, clinical perspectives and biotechnology. Nat
Prod Chem Res 3(175):2
Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG (1998) Crystal structures of human
topoisomerase I in covalent and noncovalent complexes with DNA. Science 279:1504–1513
Rehman S, Shawl AS, Kour A, Andrabi R, Sudan P (2008) Sultan P (2008) An endophytic
Neurospora sp from Nothapodytes foetida producing camptothecin. Appl Biochem Microbiol
44:203–209
Rehman S, Shawl AS, Kour A, Sultan P, Ahmad K, Khajuria R, Qazi GN (2009) Comparative
studies and identification of camptothecin produced by an endophyte at shake flask and
bioreactor. Nat Prod Res 23:1050–1057
Sadre R, Magallanes-Lundback M, Pradhan S, Salim V, Mesberg A, Jones AD, DellaPenna D.
Metabolite diversity in alkaloid biosynthesis: a multi-lane (diastereomer) highway for
camptothecin synthesis in Camptotheca acuminata. The Plant Cell Online. tpc-00193
Samuelsson G (2004) Drugs of natural origin: a textbook of pharmacognosy, 5th edn. Swedish
pharmaceutical press, Stokkholm
Sasidharan S, Saudagar P (2019) Plant metabolites as new leads to drug discovery. In: Natural
bio-active compounds, Springer, Singapore, pp 275–295
Shweta S, Zuhlke S, Ramesha BT, Priti V, Kumar PM, Ravikanth G, Spitellar M, Vasudeva R,
Shaanker RU (2010) Endophytic fungal strains of Fusarium solani from Apodytes dimidiata E.
Mey. Ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and
9-methoxycamptothecin. Phytochemistry 71:117–22
Shweta S, Gurumurthy BR, Ravikanth G, Ramanan US, Shivanna MB (2013) Endophytic fungi
from Miquelia dentata Bedd., produce the anti-cancer alkaloid, camptothecine.
Phytomedicine.:337–42
Soujanya KN, Siva R, Kumara PM, Srimany A, Ravikanth G, Mulani FA, Aarthy T,
Thulasiram HV, Santhoshkumar TR, Nataraja KN, Shaanker RU (2017) Camptothecinproducing endophytic bacteria from Pyrenacantha volubilis Hook. (Icacinaceae): a possible role
of a plasmid in the production of camptothecin. Phytomedicine 36:160–167
Sriram D, Yogeeswari P, Thirumurugan R, Ratan BT (2005) Camptothecin and its analogues: a
review on their chemotherapeutic potential. Nat Prod Res 19(4):393–412
Tafur S, Nelson JD, Delong DC, Svoboda GH (1979) Antiviral components of Ophiorrhiza
mungos. Isolation of camptothecin and 10-methoxycamptothecin. Lloydia 39:261–262
Uma SR, Ramesha BT, Ravikanth G, Gunaga RP, Vasudeva R, Ganeshaiah KN (2008) Chemical
profiling of Nothapodytes nimmoniana for camptothecin, an important anticancer alkaloid:
towards the development of a sustainable production system. In: Ramawat KG, Merillon JM
(eds) Bioactive molecules and medicinal plants. Springer, Berlin, Heidelberg, pp 197–213
Upadhya V, Pai SR, Sharma AK, Hegde HV, Kholkute SD, Joshi RK (2014) Compound specific
extraction of camptothecin from Nothapodytes nimmoniana and Piperine from Piper nigrum
using accelerated solvent extractor. J Anal Methods Chem
Uzma F, Mohan CD, Hashem A, Konappa NM, Rangappa S, Kamath PV, Singh BP, Mudili V,
Gupta VK, Siddaiah CN, Chowdappa S (2018) Endophytic fungi—alternative sources of
cytotoxic compounds: a review. Front Pharm 9:309
Venditto VJ, Simanek EE (2010) Cancer therapies utilizing the camptothecins: a review of the
in vivo literature. Mol Pharm 7(2):307–349
Wall ME, Wani MC, Cook CE, Palmer KH, McPhail AT, Sim GA (1966) Plant antitumor agents.
The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor
from Camptotheca acuminata. J Am Chem Soc 88:3888–3890
326
M. K. Swamy et al.
Khajuria RK, Puri SC, Qazi GN (2008) Prospecting for camptothecines from Nothapodytes
nimmoniana in the Western Ghats, south India: identification of high-yielding sources of
campthecin and new families of camptothecines. J Chromatogr Sci 46:362–368
Ravichandra V, Ramesh C, Swamy MK, Purushotham B, Rudramurthy GR (2018) Anticancer plants:
chemistry, pharmacology, and potential applications. In: Akhtar MS, Swamy MK
(eds) Anticancer plants: properties and application, vol 1. Springer Nature, Singapore, pp 485–515
Raveendran VV (2015) Camptothecin-discovery, clinical perspectives and biotechnology. Nat
Prod Chem Res 3(175):2
Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG (1998) Crystal structures of human
topoisomerase I in covalent and noncovalent complexes with DNA. Science 279:1504–1513
Rehman S, Shawl AS, Kour A, Andrabi R, Sudan P (2008) Sultan P (2008) An endophytic
Neurospora sp from Nothapodytes foetida producing camptothecin. Appl Biochem Microbiol
44:203–209
Rehman S, Shawl AS, Kour A, Sultan P, Ahmad K, Khajuria R, Qazi GN (2009) Comparative
studies and identification of camptothecin produced by an endophyte at shake flask and
bioreactor. Nat Prod Res 23:1050–1057
Sadre R, Magallanes-Lundback M, Pradhan S, Salim V, Mesberg A, Jones AD, DellaPenna D.
Metabolite diversity in alkaloid biosynthesis: a multi-lane (diastereomer) highway for
camptothecin synthesis in Camptotheca acuminata. The Plant Cell Online. tpc-00193
Samuelsson G (2004) Drugs of natural origin: a textbook of pharmacognosy, 5th edn. Swedish
pharmaceutical press, Stokkholm
Sasidharan S, Saudagar P (2019) Plant metabolites as new leads to drug discovery. In: Natural
bio-active compounds, Springer, Singapore, pp 275–295
Shweta S, Zuhlke S, Ramesha BT, Priti V, Kumar PM, Ravikanth G, Spitellar M, Vasudeva R,
Shaanker RU (2010) Endophytic fungal strains of Fusarium solani from Apodytes dimidiata E.
Mey. Ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and
9-methoxycamptothecin. Phytochemistry 71:117–22
Shweta S, Gurumurthy BR, Ravikanth G, Ramanan US, Shivanna MB (2013) Endophytic fungi
from Miquelia dentata Bedd., produce the anti-cancer alkaloid, camptothecine.
Phytomedicine.:337–42
Soujanya KN, Siva R, Kumara PM, Srimany A, Ravikanth G, Mulani FA, Aarthy T,
Thulasiram HV, Santhoshkumar TR, Nataraja KN, Shaanker RU (2017) Camptothecinproducing endophytic bacteria from Pyrenacantha volubilis Hook. (Icacinaceae): a possible role
of a plasmid in the production of camptothecin. Phytomedicine 36:160–167
Sriram D, Yogeeswari P, Thirumurugan R, Ratan BT (2005) Camptothecin and its analogues: a
review on their chemotherapeutic potential. Nat Prod Res 19(4):393–412
Tafur S, Nelson JD, Delong DC, Svoboda GH (1979) Antiviral components of Ophiorrhiza
mungos. Isolation of camptothecin and 10-methoxycamptothecin. Lloydia 39:261–262
Uma SR, Ramesha BT, Ravikanth G, Gunaga RP, Vasudeva R, Ganeshaiah KN (2008) Chemical
profiling of Nothapodytes nimmoniana for camptothecin, an important anticancer alkaloid:
towards the development of a sustainable production system. In: Ramawat KG, Merillon JM
(eds) Bioactive molecules and medicinal plants. Springer, Berlin, Heidelberg, pp 197–213
Upadhya V, Pai SR, Sharma AK, Hegde HV, Kholkute SD, Joshi RK (2014) Compound specific
extraction of camptothecin from Nothapodytes nimmoniana and Piperine from Piper nigrum
using accelerated solvent extractor. J Anal Methods Chem
Uzma F, Mohan CD, Hashem A, Konappa NM, Rangappa S, Kamath PV, Singh BP, Mudili V,
Gupta VK, Siddaiah CN, Chowdappa S (2018) Endophytic fungi—alternative sources of
cytotoxic compounds: a review. Front Pharm 9:309
Venditto VJ, Simanek EE (2010) Cancer therapies utilizing the camptothecins: a review of the
in vivo literature. Mol Pharm 7(2):307–349
Wall ME, Wani MC, Cook CE, Palmer KH, McPhail AT, Sim GA (1966) Plant antitumor agents.
The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor
from Camptotheca acuminata. J Am Chem Soc 88:3888–3890
326
M. K. Swamy et al.