Lorence A, Nessler CL (2004) Camptothecin, over four decades of surprising findings.
Phytochemistry 65(2004):2735–2749
Mao Y, Sun M, Desai SD, Liu LF (2000) SUMO-1 conjugation to topoisomerase I: a possible
repair response to topoisomerase-mediated DNA damage. Proc Natl Acad Sci 97(8):4046–
4051
Marchand C, Antony S, Kohn KW, Cushman M, Ioanoviciu A et al (2006) A novel
norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary
trapping of the topoisomerase I-DNA covalent complex. Mol Cancer Ther 5:287–295
Martino E, Della Volpe S, Terribile E, Benetti E, Sakaj M, Centamore A, Sala A, Collina S (2016)
The long story of camptothecin: from traditional medicine to drugs. Bioorgan Med Chem Lett
Mo YY, Yu Y, Shen Z, Beck WT (2002) Nucleolar delocalization of human topoisomerase I in
response to topotecan correlates with sumoylation of the protein. J Biol Chem 277(4):2958–
2964
Moore BG, Schwartz HS, Hodo H (1970) Inhibition of Macromolecule Synthesis in LI210 Ascites
Tumor Cells. J Cell Biol 47(144A).
Morris EJ, Geller HM (1996) Induction of neuronal apoptosis by camptothecin, an inhibitor of
DNA topoisomerase-I: evidence for cell cycle-independent toxicity. J Cell Biol 134(3):757–
770
Musavi SF, Dhavale A, Balakrishnan RM (2015) Optimization and kinetic modeling of
cell-associated camptothecin production from an endophytic Fusarium oxysporum NFX06.
Prep Biochem Biotechnol 45:158–172
Namdeo AG, Priya T, Bhosale BB (2012) Micropropagation and production of camptothecin form
in vitro plants of Ophiorrhiza mungos. Asian Pac J Trop Biomed 2(2):S662–S666
Oberlies NH, Kroll DJ (2004) Camptothecin and taxol: historic achievements in natural products
research. J Nat Prod 67(2):129–135
Park SY, Cheng YC (2005) Poly (ADP-ribose) polymerase-1 could facilitate the religation of
topoisomerase I-linked DNA inhibited by camptothecin. Can Res 65(9):3894–3902
Perdue RE Jr, Abbott BJ, Hartwell JL (1970) Screening plants for antitumor activity II: a
comparison of two methods of sampling herbaceous plants. Lloydia 33:1–6
Pommier Y (2006) Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer
6:789–802
Pommier Y, Marchand C (2012) Interfacial inhibitors: targeting macromolecular complexes. Nat
Rev Drug Discov 11:25–36
Pommier Y (2009) DNA topoisomerase I inhibitors: chemistry biology and interfacial inhibition.
Chem Rev 109:2894–2902
Prakash L, Middha SK, Mohanty SK et al (2016) 3 Biotech 6:171. https://doi.org/10.1007/s13205016-0490-y
Pu X, Zhang CR, Zhu L, Li QL, Huang QM, Zhang L, Luo YG (2019) Possible clues for
camptothecin biosynthesis from the metabolites in camptothecin-producing plants. Fitoterapia
134:113–128
Pu X, Qu X, Chen F, Bao J, Zhang G, Luo Y (2013) Camptothecin-producing endophytic fungus
Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production. Applied microbiology and biotechnology. 2013 Nov
1;97(21):9365–75
Puri SC, Verma V, Amna T, Qazi GN, Spiteller M (2005) An endophytic fungus from
Nothapodytes foetida that produces camptothecin. J Nat Prod 68:1717–1719
Rahier NJ, Thomas CJ, Hecht SM (2005) Camptothecin and its analogs. In: Cragg GM,
Kingston DGI, Newman DJ (eds) Anticancer agents from natural products. Brunner-Routledge
Psychology Press, Taylor and Francis Group, Boca Raton, Chapter 2. 5
Rallabhandi P, Hashimoto K, Mo YY, Beck WT, Moitra PK, D’Arpa P (2002) Sumoylation of
topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its
clearing from nucleoli in response to camptothecin. J Biol Chem 277(42):40020–40026
Ramawat KG, Goyal S. Natural products in cancer chemoprevention and chemotherapy. In: Herbal
drugs: ethnomedicine to modern medicine. Springer, Berlin, Heidelberg, pp 153–171
9 Camptothecin: Occurrence, Chemistry and Mode of Action
325
Phytochemistry 65(2004):2735–2749
Mao Y, Sun M, Desai SD, Liu LF (2000) SUMO-1 conjugation to topoisomerase I: a possible
repair response to topoisomerase-mediated DNA damage. Proc Natl Acad Sci 97(8):4046–
4051
Marchand C, Antony S, Kohn KW, Cushman M, Ioanoviciu A et al (2006) A novel
norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary
trapping of the topoisomerase I-DNA covalent complex. Mol Cancer Ther 5:287–295
Martino E, Della Volpe S, Terribile E, Benetti E, Sakaj M, Centamore A, Sala A, Collina S (2016)
The long story of camptothecin: from traditional medicine to drugs. Bioorgan Med Chem Lett
Mo YY, Yu Y, Shen Z, Beck WT (2002) Nucleolar delocalization of human topoisomerase I in
response to topotecan correlates with sumoylation of the protein. J Biol Chem 277(4):2958–
2964
Moore BG, Schwartz HS, Hodo H (1970) Inhibition of Macromolecule Synthesis in LI210 Ascites
Tumor Cells. J Cell Biol 47(144A).
Morris EJ, Geller HM (1996) Induction of neuronal apoptosis by camptothecin, an inhibitor of
DNA topoisomerase-I: evidence for cell cycle-independent toxicity. J Cell Biol 134(3):757–
770
Musavi SF, Dhavale A, Balakrishnan RM (2015) Optimization and kinetic modeling of
cell-associated camptothecin production from an endophytic Fusarium oxysporum NFX06.
Prep Biochem Biotechnol 45:158–172
Namdeo AG, Priya T, Bhosale BB (2012) Micropropagation and production of camptothecin form
in vitro plants of Ophiorrhiza mungos. Asian Pac J Trop Biomed 2(2):S662–S666
Oberlies NH, Kroll DJ (2004) Camptothecin and taxol: historic achievements in natural products
research. J Nat Prod 67(2):129–135
Park SY, Cheng YC (2005) Poly (ADP-ribose) polymerase-1 could facilitate the religation of
topoisomerase I-linked DNA inhibited by camptothecin. Can Res 65(9):3894–3902
Perdue RE Jr, Abbott BJ, Hartwell JL (1970) Screening plants for antitumor activity II: a
comparison of two methods of sampling herbaceous plants. Lloydia 33:1–6
Pommier Y (2006) Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer
6:789–802
Pommier Y, Marchand C (2012) Interfacial inhibitors: targeting macromolecular complexes. Nat
Rev Drug Discov 11:25–36
Pommier Y (2009) DNA topoisomerase I inhibitors: chemistry biology and interfacial inhibition.
Chem Rev 109:2894–2902
Prakash L, Middha SK, Mohanty SK et al (2016) 3 Biotech 6:171. https://doi.org/10.1007/s13205016-0490-y
Pu X, Zhang CR, Zhu L, Li QL, Huang QM, Zhang L, Luo YG (2019) Possible clues for
camptothecin biosynthesis from the metabolites in camptothecin-producing plants. Fitoterapia
134:113–128
Pu X, Qu X, Chen F, Bao J, Zhang G, Luo Y (2013) Camptothecin-producing endophytic fungus
Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production. Applied microbiology and biotechnology. 2013 Nov
1;97(21):9365–75
Puri SC, Verma V, Amna T, Qazi GN, Spiteller M (2005) An endophytic fungus from
Nothapodytes foetida that produces camptothecin. J Nat Prod 68:1717–1719
Rahier NJ, Thomas CJ, Hecht SM (2005) Camptothecin and its analogs. In: Cragg GM,
Kingston DGI, Newman DJ (eds) Anticancer agents from natural products. Brunner-Routledge
Psychology Press, Taylor and Francis Group, Boca Raton, Chapter 2. 5
Rallabhandi P, Hashimoto K, Mo YY, Beck WT, Moitra PK, D’Arpa P (2002) Sumoylation of
topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its
clearing from nucleoli in response to camptothecin. J Biol Chem 277(42):40020–40026
Ramawat KG, Goyal S. Natural products in cancer chemoprevention and chemotherapy. In: Herbal
drugs: ethnomedicine to modern medicine. Springer, Berlin, Heidelberg, pp 153–171
9 Camptothecin: Occurrence, Chemistry and Mode of Action
325