Hsiang YH, Hertzberg R, Hecht S, Liu LF (1985) Camptothecin induces protein-linked DNA
breaks via mammalian DNA topoisomerase I. J Bio Chem. 1985 Nov 25, 260(27):14873–8
Hsiang YH, Liu LF, Wall ME, Wani MC, Nicholas AW (1989) DNA topoisomerase I-mediated
DNA cleavage and cytotoxicity of camptothecin analogues. Cancer Res 49:4385–4389
Isah T, Mujib A (2015) Camptothecin from Nothapodytes nimmoniana: review on biotechnology
applications. Acta Physiol Plant 37(6):106
Kacprzak KM (2013) Chemistry and biology of camptothecin and its derivatives. In: Natural
products. Springer, Berlin, Heidelberg, pp 643–682
Kai G, Wu C, Gen L, Zhang L, Cui L, Ni X (2015) Biosynthesis and biotechnological production
of anti-cancer drug Camptothecin. Phytochemistry Reviews. 2015 Jun 1;14(3):525–39
Kaushik PS, Swamy MK, Balasubramanya S, Anuradha M. Rapid plant regeneration, analysis of
genetic fidelity and camptothecin content of micropropagated plants of Ophiorrhiza mungos
Linn.—a potent anticancer plant. J Crop Sci Biotechnol 18(1):1–8
Kehrer DFS, Soepenberg O, Loos WJ, Verweil J, Sparreboom A (2001) Modulation of
camptothecin analogues in the treatment o cancer: a review. Anticancer Drugs 12:89–106
Kessel D (1971a) Some determinants of camptothecin responsiveness in leukemia L1210 cells.
Cancer Res 31:883–887
Kessel D (1971b) Effects of camptothecin on RNA synthesis in leukemia L1210 cells. Biochim
Biophys Acta 246:225–232
Khan N, Tamboli ET, Sharma VK, Kumar S (2013) Phytochemical and pharmacolo-gical aspects
of Nothapodytes nimmoniana, an overview. Herba Pol 59:53–66
Koster DA, Palle K, Bot ES, Bjornsti MA, Dekker NH (2007) Antitumour drugs impede DNA
uncoiling by topoisomerase I. Nature 448:213–217
Kulkarni AV, Patwardhan AA, Lele U, Malpathak NP (2010) Production of camptothecin in
cultures of Chonemorpha grandiflora. Pharm Res 2:296–299
Larsson S (2007) The new chemosystematics: phylogeny and phytochemistry. Phytochemistry
68:2904–2908
Lee KH (1999) Anticancer drug design based on plant-derived natural products1. J Biomed Sci 6
(4):236–250
Lee KW, Ching SM, Hoo FK, Ramachandran V, Swamy MK (2018) Traditional medicinal plants
and their therapeutic potential against major cancer types. In: Akhtar MS, Swamy MK
(eds) Anticancer plants: natural products and biotechnological implications, vol 2. Springer
International, Singapore, pp 383–410
Li F, Jiang T, Li Q, Ling X (2017) Camptothecin (CPT) and its derivatives are known to target
topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue
molecular targets for treating human disease such as cancer? Am J Cancer Res 7(12):2350
Li QY, Zu YG, Shi RZ, Yao LP (2006) Review camptothecin: current perspectives. Curr Med
Chem 13:2021–2039
Li Y, Li CJ, Yu D, Pardeep AB (2000) Potent induction of apoptosis by b- lapachone in human
multiple myeloma cell lines and patient cells. Mol Med 6:1008–1015
Liu Z, Carpenter SB, Bourgeois WJ, Yu Y, Constantin RJ, Falcon MJ et al (1998) Variations in the
secondary metabolite camptothecin in relation to tissue age and season in Camptotheca
acuminata. Tree Physiol 18:265–270
Liu K, Ding X, Deng B, Chen W (2010) 10-Hydroxycamptothecin produced by a new endophytic
Xylaria sp. M20, from Camptotheca acuminata. Biotechnol Lett 32: 689–693
Liu LF, Desai SD, Li TK, Mao Y, Sun MEI, Sim SP (2000) Mechanism of action of camptothecin.
Ann N Y Acad Sci 922(1):1–10
Ljungman M, Hanawalt PC (1996) The anti-cancer drug camptothecin inhibits elongation but
stimulates initiation of RNA polymerase II transcription. Carcinogenesis 17(1):31–36
Lodh S, Swamy MK (2019) Phytochemical aspects of medicinal plants of northeast India to
improve the gynaecological disorders: an update. In: Natural bio-active compounds. Springer,
Singapore, pp 353–367
Lopez MM, Nessler CL, McKnight TD (1994) Sites of the accumulation of the anti tumor alkaloid
camptothecin in Camptotheca acuminata. Planta Med 60:558–560
324
M. K. Swamy et al.
breaks via mammalian DNA topoisomerase I. J Bio Chem. 1985 Nov 25, 260(27):14873–8
Hsiang YH, Liu LF, Wall ME, Wani MC, Nicholas AW (1989) DNA topoisomerase I-mediated
DNA cleavage and cytotoxicity of camptothecin analogues. Cancer Res 49:4385–4389
Isah T, Mujib A (2015) Camptothecin from Nothapodytes nimmoniana: review on biotechnology
applications. Acta Physiol Plant 37(6):106
Kacprzak KM (2013) Chemistry and biology of camptothecin and its derivatives. In: Natural
products. Springer, Berlin, Heidelberg, pp 643–682
Kai G, Wu C, Gen L, Zhang L, Cui L, Ni X (2015) Biosynthesis and biotechnological production
of anti-cancer drug Camptothecin. Phytochemistry Reviews. 2015 Jun 1;14(3):525–39
Kaushik PS, Swamy MK, Balasubramanya S, Anuradha M. Rapid plant regeneration, analysis of
genetic fidelity and camptothecin content of micropropagated plants of Ophiorrhiza mungos
Linn.—a potent anticancer plant. J Crop Sci Biotechnol 18(1):1–8
Kehrer DFS, Soepenberg O, Loos WJ, Verweil J, Sparreboom A (2001) Modulation of
camptothecin analogues in the treatment o cancer: a review. Anticancer Drugs 12:89–106
Kessel D (1971a) Some determinants of camptothecin responsiveness in leukemia L1210 cells.
Cancer Res 31:883–887
Kessel D (1971b) Effects of camptothecin on RNA synthesis in leukemia L1210 cells. Biochim
Biophys Acta 246:225–232
Khan N, Tamboli ET, Sharma VK, Kumar S (2013) Phytochemical and pharmacolo-gical aspects
of Nothapodytes nimmoniana, an overview. Herba Pol 59:53–66
Koster DA, Palle K, Bot ES, Bjornsti MA, Dekker NH (2007) Antitumour drugs impede DNA
uncoiling by topoisomerase I. Nature 448:213–217
Kulkarni AV, Patwardhan AA, Lele U, Malpathak NP (2010) Production of camptothecin in
cultures of Chonemorpha grandiflora. Pharm Res 2:296–299
Larsson S (2007) The new chemosystematics: phylogeny and phytochemistry. Phytochemistry
68:2904–2908
Lee KH (1999) Anticancer drug design based on plant-derived natural products1. J Biomed Sci 6
(4):236–250
Lee KW, Ching SM, Hoo FK, Ramachandran V, Swamy MK (2018) Traditional medicinal plants
and their therapeutic potential against major cancer types. In: Akhtar MS, Swamy MK
(eds) Anticancer plants: natural products and biotechnological implications, vol 2. Springer
International, Singapore, pp 383–410
Li F, Jiang T, Li Q, Ling X (2017) Camptothecin (CPT) and its derivatives are known to target
topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue
molecular targets for treating human disease such as cancer? Am J Cancer Res 7(12):2350
Li QY, Zu YG, Shi RZ, Yao LP (2006) Review camptothecin: current perspectives. Curr Med
Chem 13:2021–2039
Li Y, Li CJ, Yu D, Pardeep AB (2000) Potent induction of apoptosis by b- lapachone in human
multiple myeloma cell lines and patient cells. Mol Med 6:1008–1015
Liu Z, Carpenter SB, Bourgeois WJ, Yu Y, Constantin RJ, Falcon MJ et al (1998) Variations in the
secondary metabolite camptothecin in relation to tissue age and season in Camptotheca
acuminata. Tree Physiol 18:265–270
Liu K, Ding X, Deng B, Chen W (2010) 10-Hydroxycamptothecin produced by a new endophytic
Xylaria sp. M20, from Camptotheca acuminata. Biotechnol Lett 32: 689–693
Liu LF, Desai SD, Li TK, Mao Y, Sun MEI, Sim SP (2000) Mechanism of action of camptothecin.
Ann N Y Acad Sci 922(1):1–10
Ljungman M, Hanawalt PC (1996) The anti-cancer drug camptothecin inhibits elongation but
stimulates initiation of RNA polymerase II transcription. Carcinogenesis 17(1):31–36
Lodh S, Swamy MK (2019) Phytochemical aspects of medicinal plants of northeast India to
improve the gynaecological disorders: an update. In: Natural bio-active compounds. Springer,
Singapore, pp 353–367
Lopez MM, Nessler CL, McKnight TD (1994) Sites of the accumulation of the anti tumor alkaloid
camptothecin in Camptotheca acuminata. Planta Med 60:558–560
324
M. K. Swamy et al.