Amna T, Puri SC, Verma V, Sharma JP, Khajuria RK, Musarrat J et al (2006) Bioreactor studies
on the endophytic fungus Entrophospora infrequens for the production of an anticancer
alkaloid camptothecin. Can J Microbiol 52:189–196
Arbain D, Putra DP, Sargent MV (1993) The alkaloids of Ophiorrhiza filistipula. Aust J Chem 46
(1993):977–985
Arisawa M, Gunasekera SP, Cordell GA, Farmsworth NA (1981) Plant anticancer agents XXI.
constituents of merrilliodendron megacarpum. Planta Med 43(1981):404–407
Bai YH, Song QS (2014) Chemical constituents from the roots of Nothapodytes pittosporoides.
Nat Prod Res Dev 26:197–201
Bhalkar BN, Bedekar PA, Kshirsagar SD, Govindwar SP (2016) Solid state fermentation of
soybean waste and an up-flow column bioreactor for continuous production of camptothecine
by an endophytic fungus Fusarium oxysporum. RSC Adv 6(61):56527–56536
Champoux JJ (2001) DNA topoisomerases: structure function and mechanism. Annu Rev
Biochem 70:369–413
Clarance P, Khusro A, Lalitha J, Sales J, Paul A (2019) Optimization of camptothecin production
and biomass yield from endophytic fungus Fusarium solani strain ATLOY-8. J Appl Pharm
Sci 9(10):035–046
Cliby WA, Lewis KA, Lilly KK, Kaufmann SH (2002) S Phase and G2 arrests induced by
topoisomerase I poisons are dependent on ATR kinase function. J Biol Chem 277:1599–1606
Das BB, Shar-yin NH, Murai J, Rehman I, Amé JC, Sengupta S, Das SK, Majumdar P, Zhang H,
Biard D, Majumder HK (2014) PARP1–TDP1 coupling for the repair of topoisomerase I–
induced DNA damage. Nucleic Acids Res p.gku088.
Das SK, Rehman I, Ghosh A, Sengupta S, Majumdar P, Jana B, Das BB (2016) Poly (ADP-ribose)
polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity
in living cells. Nucleic Acids Res p.gkw665.
David A, Michael RZ (2010) Cancer: an old disease, a new disease or something in between?. Nat
Rev Cancer 10(10):728–733
De LV, St-Pierre B (2000) The cell and development biology of alkaloid biosynthesis. Trends in
Plant Sci 5:168–173
Deorukhkar A, Krishnan S, Sethi G, Aggarwal BB (2007) Back to basics: how natural products
can provide the basis for new therapeutics. Expert Opin Investig Drugs 16(11):1753–1773
Desai SD, Li TK, Rodriguez-Bauman A, Rubin EH, Liu LF (2001) Ubiquitin/26S
proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells. Can Res 61(15):5926–5932
Desai SD, Liu LF, Vazquez-Abad D, D’Arpa P (1997) Ubiquitin-dependent destruction of
topoisomerase I is stimulated by the antitumor drug camptothecin. J Biol Chem 272
(39):24159–24164
Ding X, Liu K, Deng B, Chen W, Li W, Liu F (2013) Isolation and characterization of endophytic
fungi from Camptotheca acuminata. World Journal of Microbiology and Biotechnology.
2013 Oct 1, 29(10):1831–8
Efferth T, Fu YJ, Zu YG, Schwarz G, Konkimalla VS, Wink M (2007) Molecular target-guided
tumor therapy with natural products derived from traditional Chinese medicine. Curr Med
Chem 14(19):2024–2032
Govindachari TR, Viswnathan N (1972) the stem bark of Mappia foetida, a tree native to India,
has proved to be another source significant for the isolation of camptothecin. Phytochemistry
11(12):3529–3531
Gunasekera SP, Badawi MM, Cordell GA, Farnsworth NR, Chitnis M (1981) Plant anticancer
agents X. Isolation of camptothecin and 9-methoxycamptothecin from Ervatamia heyneana.
J Nat Prod 42 (1979) 475–477
Hartwell JL (1970) Plants used against cancer a Survey. Lloydia 33:97–194
Horwitz SB, Chang CK, Grollman AP (1971) Studies on Camptothecin. I. effects on nucleic acid
and protein synthesis. Mol Pharmacol 7:632–644
Hsiang YH, Liu LF (1988) Identification of mammalian DNA topoisomerase I as an intracellular
target of the anticancer drug camptothecin. Cancer Res 48:1722–1726
9 Camptothecin: Occurrence, Chemistry and Mode of Action
323
on the endophytic fungus Entrophospora infrequens for the production of an anticancer
alkaloid camptothecin. Can J Microbiol 52:189–196
Arbain D, Putra DP, Sargent MV (1993) The alkaloids of Ophiorrhiza filistipula. Aust J Chem 46
(1993):977–985
Arisawa M, Gunasekera SP, Cordell GA, Farmsworth NA (1981) Plant anticancer agents XXI.
constituents of merrilliodendron megacarpum. Planta Med 43(1981):404–407
Bai YH, Song QS (2014) Chemical constituents from the roots of Nothapodytes pittosporoides.
Nat Prod Res Dev 26:197–201
Bhalkar BN, Bedekar PA, Kshirsagar SD, Govindwar SP (2016) Solid state fermentation of
soybean waste and an up-flow column bioreactor for continuous production of camptothecine
by an endophytic fungus Fusarium oxysporum. RSC Adv 6(61):56527–56536
Champoux JJ (2001) DNA topoisomerases: structure function and mechanism. Annu Rev
Biochem 70:369–413
Clarance P, Khusro A, Lalitha J, Sales J, Paul A (2019) Optimization of camptothecin production
and biomass yield from endophytic fungus Fusarium solani strain ATLOY-8. J Appl Pharm
Sci 9(10):035–046
Cliby WA, Lewis KA, Lilly KK, Kaufmann SH (2002) S Phase and G2 arrests induced by
topoisomerase I poisons are dependent on ATR kinase function. J Biol Chem 277:1599–1606
Das BB, Shar-yin NH, Murai J, Rehman I, Amé JC, Sengupta S, Das SK, Majumdar P, Zhang H,
Biard D, Majumder HK (2014) PARP1–TDP1 coupling for the repair of topoisomerase I–
induced DNA damage. Nucleic Acids Res p.gku088.
Das SK, Rehman I, Ghosh A, Sengupta S, Majumdar P, Jana B, Das BB (2016) Poly (ADP-ribose)
polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity
in living cells. Nucleic Acids Res p.gkw665.
David A, Michael RZ (2010) Cancer: an old disease, a new disease or something in between?. Nat
Rev Cancer 10(10):728–733
De LV, St-Pierre B (2000) The cell and development biology of alkaloid biosynthesis. Trends in
Plant Sci 5:168–173
Deorukhkar A, Krishnan S, Sethi G, Aggarwal BB (2007) Back to basics: how natural products
can provide the basis for new therapeutics. Expert Opin Investig Drugs 16(11):1753–1773
Desai SD, Li TK, Rodriguez-Bauman A, Rubin EH, Liu LF (2001) Ubiquitin/26S
proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells. Can Res 61(15):5926–5932
Desai SD, Liu LF, Vazquez-Abad D, D’Arpa P (1997) Ubiquitin-dependent destruction of
topoisomerase I is stimulated by the antitumor drug camptothecin. J Biol Chem 272
(39):24159–24164
Ding X, Liu K, Deng B, Chen W, Li W, Liu F (2013) Isolation and characterization of endophytic
fungi from Camptotheca acuminata. World Journal of Microbiology and Biotechnology.
2013 Oct 1, 29(10):1831–8
Efferth T, Fu YJ, Zu YG, Schwarz G, Konkimalla VS, Wink M (2007) Molecular target-guided
tumor therapy with natural products derived from traditional Chinese medicine. Curr Med
Chem 14(19):2024–2032
Govindachari TR, Viswnathan N (1972) the stem bark of Mappia foetida, a tree native to India,
has proved to be another source significant for the isolation of camptothecin. Phytochemistry
11(12):3529–3531
Gunasekera SP, Badawi MM, Cordell GA, Farnsworth NR, Chitnis M (1981) Plant anticancer
agents X. Isolation of camptothecin and 9-methoxycamptothecin from Ervatamia heyneana.
J Nat Prod 42 (1979) 475–477
Hartwell JL (1970) Plants used against cancer a Survey. Lloydia 33:97–194
Horwitz SB, Chang CK, Grollman AP (1971) Studies on Camptothecin. I. effects on nucleic acid
and protein synthesis. Mol Pharmacol 7:632–644
Hsiang YH, Liu LF (1988) Identification of mammalian DNA topoisomerase I as an intracellular
target of the anticancer drug camptothecin. Cancer Res 48:1722–1726
9 Camptothecin: Occurrence, Chemistry and Mode of Action
323