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perspective. Phytochemistry 64:3–19
Wright CM, van der Merwe M, DeBrot AH, Bjornsti MA (2015) DNA topoisomerase I domain
interactions impact enzyme activity and sensitivity to camptothecin. J Biol Chem 290
(19):12068–12078
Yan XF, Wang Y, Yu T, Zhang YH, Dai SJ (2003) Variation in camptothecin content in
Camptotheca accuminata leaves. Bot Bull Acad Sin 44:99–105
Zhang ZB, Cheng B, Tse-Dinh YC (2011) Crystal structure of a covalent intermediate in DNA
cleavage and rejoining by Escherichia coli DNA topoisomerase I. Proc Natl Acad Sci USA
108:6939–6944
Zunino F, Dallavalle S, Laccabue D, Beretta G, Merlini L, Pratesi G (2002) Current status and
perspectives in the development of camptothecins. Curr Pharm Des 8(27):2505–2520
9 Camptothecin: Occurrence, Chemistry and Mode of Action
327
perspective. Phytochemistry 64:3–19
Wright CM, van der Merwe M, DeBrot AH, Bjornsti MA (2015) DNA topoisomerase I domain
interactions impact enzyme activity and sensitivity to camptothecin. J Biol Chem 290
(19):12068–12078
Yan XF, Wang Y, Yu T, Zhang YH, Dai SJ (2003) Variation in camptothecin content in
Camptotheca accuminata leaves. Bot Bull Acad Sin 44:99–105
Zhang ZB, Cheng B, Tse-Dinh YC (2011) Crystal structure of a covalent intermediate in DNA
cleavage and rejoining by Escherichia coli DNA topoisomerase I. Proc Natl Acad Sci USA
108:6939–6944
Zunino F, Dallavalle S, Laccabue D, Beretta G, Merlini L, Pratesi G (2002) Current status and
perspectives in the development of camptothecins. Curr Pharm Des 8(27):2505–2520
9 Camptothecin: Occurrence, Chemistry and Mode of Action
327