films for rizatriptan benzoate delivery. In these buccal films, tamarind seed
xyloglucan and Carbopol 934 P were used as mucoadhesive agents. The in vitro
rizatriptan benzoate permeation from these buccal films across the porcine buccal
mucosal membrane exhibited desirable flux over a prolonged time. Hasnain et al.
(2020b) investigated the application of dillenia fruit gum as mucoadhesive film
former excipient in the formulation of atenolol buccal patches to treat hypertension.
They formulated atenolol buccal patches composed of a mucoadhesive layer of
dillenia fruit gum-hydroxypropyl methylcellulose K4M and a backing layer
(drug-free) of 1% ethyl cellulose via solvent-casting method. The ex vivo atenolol
Fig. 3.14 Comparative results of buccoadhesive tablet acceptance for curcumin buccal tablets
(Gowthamarajan et al. 2012; Copyright @ 2012, with permission from Elsevier Ltd.)
Fig. 3.15 The comparative in vitro release of curcumin from buccoadhesive tablets prepared
using 20% cashew gum and 20% hydroxypropyl methylcellulose (Gowthamarajan et al. 2012;
Copyright @ 2012, with permission from Elsevier Ltd.)
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A. K. Nayak et al.
xyloglucan and Carbopol 934 P were used as mucoadhesive agents. The in vitro
rizatriptan benzoate permeation from these buccal films across the porcine buccal
mucosal membrane exhibited desirable flux over a prolonged time. Hasnain et al.
(2020b) investigated the application of dillenia fruit gum as mucoadhesive film
former excipient in the formulation of atenolol buccal patches to treat hypertension.
They formulated atenolol buccal patches composed of a mucoadhesive layer of
dillenia fruit gum-hydroxypropyl methylcellulose K4M and a backing layer
(drug-free) of 1% ethyl cellulose via solvent-casting method. The ex vivo atenolol
Fig. 3.14 Comparative results of buccoadhesive tablet acceptance for curcumin buccal tablets
(Gowthamarajan et al. 2012; Copyright @ 2012, with permission from Elsevier Ltd.)
Fig. 3.15 The comparative in vitro release of curcumin from buccoadhesive tablets prepared
using 20% cashew gum and 20% hydroxypropyl methylcellulose (Gowthamarajan et al. 2012;
Copyright @ 2012, with permission from Elsevier Ltd.)
114
A. K. Nayak et al.