blends (Nayak and Pal 2013c) to formulate two different kinds of mucoadhesive
beads of metformin HCl by ionotropic gelation was also studied and reported.
These beads showed a prolonged metformin HCl release over 10 h, in vitro and
significant antidiabetic effects, in vivo. In another research, the applicability of
jackfruit seed starch-sodium alginate blends for the preparation of controlled drug
releasing was investigated using pioglitazone as a model drug (Nayak et al. 2013c).
Malakar et al. (2013b) studied the efficacy of potato starch used as release retardant
blends with sodium alginate to formulate potato starch-alginate beads of tolbutamide and these beads showed a controlled tolbutamide releasing pattern, in vitro.
Even various plant polysaccharides have been used to formulate buoyant beads for
the uses in floating drug delivery. Bera et al. (2015b) developed alginate-sterculia
gum gel-coated oil-entrapped calcium alginate beads of resperidone for gastrorentive floating drug delivery. In this work, sterculia gum coat was applied for its
bioadhesive nature and these alginate-sterculia gum gel-coated buoyant bioadhesive
beads exhibited prolonged release resperidone over 8 h in gastric pH medium.
Scanning electron microphotographs exhibited rough surface morphology of the
uncoated oil-entrapped calcium alginate beads of resperidone; whereas in case of
the alginate-sterculia gum gel-coated oil-entrapped calcium alginate beads of resperidone, comparatively smooth surface morphology was noticed. The crosssectional view of the alginate-sterculia gum gel-coated oil-entrapped calcium
alginate beads of resperidone exhibited a sponge like structural morphology, in
which the oil was entrapped with the beads. In another work, the same research
group developed risperidone-loaded alginate gel-coated oil-entrapped alginate–tamarind gum–magnesium stearate buoyant beads for gastrorentive floating drug
delivery (Bera et al. 2015c). The use of tamarind gum in these beads imparted
sustained release and bioadhesive behavior. In a work, emulsion-gelled groundnut
oil-entrapped buoyant beads of diclofenac sodium were developed using sodium
alginate and tamarind seed polysaccharide-blends (Nayak et al. 2013d). These
groundnut oil-entrapped buoyant beads showed sustained drug releasing and
excellent floating pattern, in vitro. Guru et al. (2013) also formulated oil-entrapped
beads of aceclofenac using sterculia gum-sodium alginate blends. These beads
exhibited excellent floating behavior with prolonged sustained release of encapsulated aceclofenac.
3.3.6 Microparticles
Since past few years, many plant polysaccharides have already been exploited for
the formulation of microparticles to deliver numerous drugs due to the matrix
forming and release retarding properties of plant polysaccharides. Pal and Nayak
(2012) formulated gliclazide-loaded tamarind seed polysaccharide-calcium alginate
mucoadhesive microspheres for oral adminstration. In these biopolymeric
mucoadhesive microspheres, tamarind seed polysaccharide was employed as
release retardant and bioadhesive polymeric excipients. These beads showed a
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beads of metformin HCl by ionotropic gelation was also studied and reported.
These beads showed a prolonged metformin HCl release over 10 h, in vitro and
significant antidiabetic effects, in vivo. In another research, the applicability of
jackfruit seed starch-sodium alginate blends for the preparation of controlled drug
releasing was investigated using pioglitazone as a model drug (Nayak et al. 2013c).
Malakar et al. (2013b) studied the efficacy of potato starch used as release retardant
blends with sodium alginate to formulate potato starch-alginate beads of tolbutamide and these beads showed a controlled tolbutamide releasing pattern, in vitro.
Even various plant polysaccharides have been used to formulate buoyant beads for
the uses in floating drug delivery. Bera et al. (2015b) developed alginate-sterculia
gum gel-coated oil-entrapped calcium alginate beads of resperidone for gastrorentive floating drug delivery. In this work, sterculia gum coat was applied for its
bioadhesive nature and these alginate-sterculia gum gel-coated buoyant bioadhesive
beads exhibited prolonged release resperidone over 8 h in gastric pH medium.
Scanning electron microphotographs exhibited rough surface morphology of the
uncoated oil-entrapped calcium alginate beads of resperidone; whereas in case of
the alginate-sterculia gum gel-coated oil-entrapped calcium alginate beads of resperidone, comparatively smooth surface morphology was noticed. The crosssectional view of the alginate-sterculia gum gel-coated oil-entrapped calcium
alginate beads of resperidone exhibited a sponge like structural morphology, in
which the oil was entrapped with the beads. In another work, the same research
group developed risperidone-loaded alginate gel-coated oil-entrapped alginate–tamarind gum–magnesium stearate buoyant beads for gastrorentive floating drug
delivery (Bera et al. 2015c). The use of tamarind gum in these beads imparted
sustained release and bioadhesive behavior. In a work, emulsion-gelled groundnut
oil-entrapped buoyant beads of diclofenac sodium were developed using sodium
alginate and tamarind seed polysaccharide-blends (Nayak et al. 2013d). These
groundnut oil-entrapped buoyant beads showed sustained drug releasing and
excellent floating pattern, in vitro. Guru et al. (2013) also formulated oil-entrapped
beads of aceclofenac using sterculia gum-sodium alginate blends. These beads
exhibited excellent floating behavior with prolonged sustained release of encapsulated aceclofenac.
3.3.6 Microparticles
Since past few years, many plant polysaccharides have already been exploited for
the formulation of microparticles to deliver numerous drugs due to the matrix
forming and release retarding properties of plant polysaccharides. Pal and Nayak
(2012) formulated gliclazide-loaded tamarind seed polysaccharide-calcium alginate
mucoadhesive microspheres for oral adminstration. In these biopolymeric
mucoadhesive microspheres, tamarind seed polysaccharide was employed as
release retardant and bioadhesive polymeric excipients. These beads showed a
108
A. K. Nayak et al.