usitatisimum mucilage was used as matrix former, release retardant and mucoadhesive agents. These beads exhibited prolonged in vitro drug releasing with
excellent ex vivo biomucoadhesion. The use of jackfruit seed starch-low methoxy
pectin blends (Nayak and Pal 2013b) and jackfruit seed starch-sodium alginate
Fig. 3.7 a Comparative in vivo blood glucose level in alloxan-induced diabetic rats after oral
administration of pure metformin HCl and optimized calcium pectinate-fenugreek (Trigonella
foenum-graecum L.) seed mucilage mucoadhesive beads of metformin HCl.The data were
analyzed for significant differences (*p < 0.05) by paired samples t-test, and b comparative in vivo
mean percentage reduction in blood glucose level in alloxan-induced diabetic rats after oral
administration of pure metformin HCl and optimized calcium pectinate-fenugreek seed mucilage
mucoadhesive beads of metformin HCl (Nayak et al. 2013a; Copyright @ 2013, with permission
from Elsevier Ltd.)
Fig. 3.8 a Comparative in vivo blood glucose level in alloxan-induced diabetic rats after oral
administration of pure metformin HCl and fenugreek seed mucilage-calcium alginate beads of
metformin HCl. The data were analyzed for significant differences (p < 0.05) by paired samples
t-test. b Comparative in vivo mean percentage reduction in blood glucose level in alloxan-induced
diabetic rats after oral administration of pure metformin HCl and fenugreek seed mucilage-calcium
alginate beads of metformin HCl (Nayak et al. 2013b; Copyright @ 2012, with permission from
Elsevier B.V.)
3 Plant Polysaccharides in Pharmaceutical Applications
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