metformin HCl release over 10 h, in vitro. Even these beads exhibited excellent
bioadhesion onto goat intestinal mucosa, ex vivo and significant antidiabetic action
in alloxan-induced diabetic rats, in vivo. Sinha et al. (2015a) used okra gum as
release retardant polymeric blend with alginate to prepare zinc alginate-okra gum
beads for sustained release of diclofenac sodium (over 8 h). The same research
group, in another research, formulated okra gum-calcium alginate mucoadhesive
beads for controlled releasing glibenclamide (over 8 h) and these beads showed
excellent bioadhesion onto goat intestinal mucosa, ex vivo (Sinha et al. 2015b).
Hasnain et al. (2018a) prepared mucoadhesive beads of diclofenac sodium using
Linum usitatisimum mucilage with sodium alginate. In these beads, Linum
Fig. 3.5 Scanning electron microphotograph of the optimized calcium pectinate-fenugreek
(Trigonella foenum-graecum L.) seed mucilage mucoadhesive beads of metformin HCl (Nayak
et al. 2013a; Copyright @ 2013, with permission from Elsevier Ltd.)
Fig. 3.6 In vitro drug release from various calcium pectinate-fenugreek (Trigonella
foenum-graecum L.) seed mucilage mucoadhesive beads of metformin HCl [mean ± S.D.,
n = 3] (Nayak et al. 2013a; Copyright @ 2013, with permission from Elsevier Ltd.)
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A. K. Nayak et al.
bioadhesion onto goat intestinal mucosa, ex vivo and significant antidiabetic action
in alloxan-induced diabetic rats, in vivo. Sinha et al. (2015a) used okra gum as
release retardant polymeric blend with alginate to prepare zinc alginate-okra gum
beads for sustained release of diclofenac sodium (over 8 h). The same research
group, in another research, formulated okra gum-calcium alginate mucoadhesive
beads for controlled releasing glibenclamide (over 8 h) and these beads showed
excellent bioadhesion onto goat intestinal mucosa, ex vivo (Sinha et al. 2015b).
Hasnain et al. (2018a) prepared mucoadhesive beads of diclofenac sodium using
Linum usitatisimum mucilage with sodium alginate. In these beads, Linum
Fig. 3.5 Scanning electron microphotograph of the optimized calcium pectinate-fenugreek
(Trigonella foenum-graecum L.) seed mucilage mucoadhesive beads of metformin HCl (Nayak
et al. 2013a; Copyright @ 2013, with permission from Elsevier Ltd.)
Fig. 3.6 In vitro drug release from various calcium pectinate-fenugreek (Trigonella
foenum-graecum L.) seed mucilage mucoadhesive beads of metformin HCl [mean ± S.D.,
n = 3] (Nayak et al. 2013a; Copyright @ 2013, with permission from Elsevier Ltd.)
106
A. K. Nayak et al.