husk mucilage-zinc pectinate beads for controlled delivery of aceclofenac. These
beads showed a controlled aceclofenac releasing pattern over 10 h with favorable
pH dependent swelling. Nayak et al. (2014a; b) developed metformin HCl releasing
calcium pectinate-ispagula husk mucilage mucoadhesive beads and calcium
pectinate-tamarind seed polysaccharide mucoadhesive beads. Both the mucoadhesive bead formulations showed controlled in vitro drug releasing with good ex vivo
mucoadhesion and in vivo antidiabetic activity in diabetic rats. The same group also
developed similar kinds of calcium pectinate-fenugreek seed mucilage mucoadhesive beads for oral delivery of metformin HCl (Nayak et al. 2013a). These calcium
pectinate-fenugreek (Trigonella foenum-graecum L.) seed mucilage mucoadhesive
beads of metformin HCl were of spherical in shape with rough surface morphology
(Fig. 3.5) and exhibited controlled in vitro drug releasing over 10 h (Fig. 3.6). In
addition, these mucoadhesive beads showed significant antidiabetic action in
alloxan-induced diabetic rats, in vivo (Fig. 3.7). In another research, an almost
similar result of in vivo antidiabetic action in alloxan-induced diabetic rats was
noticed by the fenugreek seed mucilage-calcium alginate beads of metformin HCl
(Fig. 3.8) (Nayak et al. 2013b). The same research group developed metformin HCl
releasing ispaghula husk mucilage-gellan gum mucoadhesive beads for oral
administration (Nayak et al. 2014c). These ispaghula husk mucilage-gellan gum
mucoadhesive beads exhibited controlled in vitro release of metformin HCl with
good ex vivo bioadhesion. They also developed similar kinds of controlled
releasing mucoadhesive beads of metformin HCl using polymeric blends of
tamarind seed polysaccharide-gellan gum (Nayak et al. 2014b), fenugreek seed
mucilage-gellan gum (Nayak and Pal 2014) and jackfruit (Artocarpus heterophyllus
L.) seed starch-gellan gum (Nayak et al. 2014e). Tamarind seed
polysaccharide-calcium alginate beads of metformin HCl were formulated for the
use in oral administration (Nayak et al. 2016; Nayak and Pal 2013a). In these
biopolymeric beads, tamarind seed polysaccharide was employed as release retardant and bioadhesive polymeric excipients. These beads showed a prolonged
Fig. 3.4 In vitro drug release from zinc pectinate-sterculia gum interpenetrating polymer network
beads of ziprasidone HCl (Bera et al. 2015a; Copyright @ 2015, with permission from Elsevier
Ltd.)
3 Plant Polysaccharides in Pharmaceutical Applications
105
beads showed a controlled aceclofenac releasing pattern over 10 h with favorable
pH dependent swelling. Nayak et al. (2014a; b) developed metformin HCl releasing
calcium pectinate-ispagula husk mucilage mucoadhesive beads and calcium
pectinate-tamarind seed polysaccharide mucoadhesive beads. Both the mucoadhesive bead formulations showed controlled in vitro drug releasing with good ex vivo
mucoadhesion and in vivo antidiabetic activity in diabetic rats. The same group also
developed similar kinds of calcium pectinate-fenugreek seed mucilage mucoadhesive beads for oral delivery of metformin HCl (Nayak et al. 2013a). These calcium
pectinate-fenugreek (Trigonella foenum-graecum L.) seed mucilage mucoadhesive
beads of metformin HCl were of spherical in shape with rough surface morphology
(Fig. 3.5) and exhibited controlled in vitro drug releasing over 10 h (Fig. 3.6). In
addition, these mucoadhesive beads showed significant antidiabetic action in
alloxan-induced diabetic rats, in vivo (Fig. 3.7). In another research, an almost
similar result of in vivo antidiabetic action in alloxan-induced diabetic rats was
noticed by the fenugreek seed mucilage-calcium alginate beads of metformin HCl
(Fig. 3.8) (Nayak et al. 2013b). The same research group developed metformin HCl
releasing ispaghula husk mucilage-gellan gum mucoadhesive beads for oral
administration (Nayak et al. 2014c). These ispaghula husk mucilage-gellan gum
mucoadhesive beads exhibited controlled in vitro release of metformin HCl with
good ex vivo bioadhesion. They also developed similar kinds of controlled
releasing mucoadhesive beads of metformin HCl using polymeric blends of
tamarind seed polysaccharide-gellan gum (Nayak et al. 2014b), fenugreek seed
mucilage-gellan gum (Nayak and Pal 2014) and jackfruit (Artocarpus heterophyllus
L.) seed starch-gellan gum (Nayak et al. 2014e). Tamarind seed
polysaccharide-calcium alginate beads of metformin HCl were formulated for the
use in oral administration (Nayak et al. 2016; Nayak and Pal 2013a). In these
biopolymeric beads, tamarind seed polysaccharide was employed as release retardant and bioadhesive polymeric excipients. These beads showed a prolonged
Fig. 3.4 In vitro drug release from zinc pectinate-sterculia gum interpenetrating polymer network
beads of ziprasidone HCl (Bera et al. 2015a; Copyright @ 2015, with permission from Elsevier
Ltd.)
3 Plant Polysaccharides in Pharmaceutical Applications
105