464
Chang H-P, Chen Y-H (2005) Differential effects of organosulfur compounds from garlic oil on
nitric oxide and prostaglandin E2 in stimulated macrophages. Nutrition 21:530–536. https://
doi.org/10.1016/j.nut.2004.07.018
Chauhan NB (2006) Effect of aged garlic extract on APP processing and tau phosphorylation
in Alzheimer’s transgenic model Tg2576. J Ethnopharmacol. https://doi.org/10.1016/j.
jep.2006.05.030
Chen X-L, Dodd G, Kunsch C (2009) Sulforaphane inhibits TNF-α-induced activation of p38
MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells. Inflamm Res 58:513–
521. https://doi.org/10.1007/s00011-009-0017-7
Cheng AY, Fantus IG (2005) Oral antihyperglycemic therapy for type 2 diabetes mellitus. Can Med
Assoc J 172:213–226. https://doi.org/10.1503/cmaj.1031414
Cho BHS, Xu S (2000) Effects of allyl mercaptan and various allium-derived compounds on cholesterol synthesis and secretion in Hep-G2 cells. Comp Biochem Physiol C Pharmacol Toxicol
Endocrinol. https://doi.org/10.1016/S0742-8413(00)00106-7
Choi YH, Park HS (2012) Apoptosis induction of U937 human leukemia cells by diallyl trisulfide induces through generation of reactive oxygen species. J Biomed Sci. https://doi.
org/10.1186/1423-0127-19-50
Chu Y-L, Ho C-T, Chung J-G, Raghu R, Lo Y-C, Sheen L-Y (2013) Allicin induces anti-human
liver cancer cells through the p53 gene modulating apoptosis and autophagy. J Agric Food
Chem 61(41):9839–9848
Chung LY (2006) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and
allyl disulfide. J Med Food 9:205–213. https://doi.org/10.1089/jmf.2006.9.205
Colín-González AL, Santana RA, Silva-Islas CA, Chánez-Cárdenas ME, Santamaría A,
Maldonado PD (2012) The antioxidant mechanisms underlying the aged garlic extract-and
S-allylcysteine-induced protection. Oxidative Med Cell Longev 2012:1–16. https://doi.
org/10.1155/2012/907162
de Queiroz YS, Antunes PB, Vicente SJ, Sampaio GR, Shibao J, Bastos DH, Torres EA d S (2014)
Bioactive compounds, in vitro antioxidant capacity and Maillard reaction products of raw,
boiled and fried garlic (Allium sativum L.). Int J Food Sci Technol 49(5):1308–1314
Dirsch VM, Vollmar AM (2001) Ajoene, a natural product with non-steroidal anti-inflammatory
drug (NSAID)-like properties? Biochem Pharmacol 61:587–593
DiStefano JK, Watanabe RM (2010) Pharmacogenetics of anti-diabetes drugs. Pharmaceuticals
3:2610–2646. https://doi.org/10.3390/ph3082610
Duan X, Block E, Li Z, Connelly T, Zhang J, Huang Z, Su X, Pan Y, Wu L, Chi Q, Thomas
S, Zhang S, Ma M, Matsunami H, Chen G-Q, Zhang H (2012) Crucial role of copper in detection of metal-coordinating odorants. Proc Natl Acad Sci USA 109:34923497.
Bibcode:2012PNAS.109.3492D. https://doi.org/10.1073/pnas.1111297109. PMC 3295281.
PMID 22328155
Duda G, Suliburska J, Pupek-Musialik D (2008) Effects of short-term garlic supplementation on
lipid metabolism and antioxidant status in hypertensive adults. Pharmacol Rep 60:163–170
Eftekhari Z, Bahmani M, Mohsenzadeghan A et al (2012) Evaluating the anti-leech (Limnatis
nilotica) activity of methanolic extract of Allium sativum L. compared with levamisole and
metronidazole. Comp Clin Pathol 21:1219–1222. https://doi.org/10.1007/s00580-011-1268-6
Eilat S, Oestraicher Y, Rabinkov A et al (1995) Alteration of lipid profile in hyperlipidemic rabbits
by allicin, an active constituent of garlic. Coron Artery Dis 6(12):985–990
El-Demerdash F, Yousef MI, El-Naga NA (2005) Biochemical study on the hypoglycemic effects
of onion and garlic in alloxan-induced diabetic rats. Food Chem Toxicol 43(1):57–63
Elkayam A (2003) The effects of allicin on weight in fructose-induced hyperinsulinemic, hyperlipidemic, hypertensive rats. Am J Hypertens 16:1053–1056. https://doi.org/10.1016/j.
amjhyper.2003.07.011
Fenwick GR, Hanley AB, Whitaker JR (1985a) The genus Allium—part 1. Crit Rev Food Sci Nutr
22(3):199–271
Fenwick GR, Hanley AB, Whitaker JR (1985b) The genus Allium—part 3. Crit Rev Food Sci Nutr
23(1):1–73
A. M. P. Walag et al.
Chang H-P, Chen Y-H (2005) Differential effects of organosulfur compounds from garlic oil on
nitric oxide and prostaglandin E2 in stimulated macrophages. Nutrition 21:530–536. https://
doi.org/10.1016/j.nut.2004.07.018
Chauhan NB (2006) Effect of aged garlic extract on APP processing and tau phosphorylation
in Alzheimer’s transgenic model Tg2576. J Ethnopharmacol. https://doi.org/10.1016/j.
jep.2006.05.030
Chen X-L, Dodd G, Kunsch C (2009) Sulforaphane inhibits TNF-α-induced activation of p38
MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells. Inflamm Res 58:513–
521. https://doi.org/10.1007/s00011-009-0017-7
Cheng AY, Fantus IG (2005) Oral antihyperglycemic therapy for type 2 diabetes mellitus. Can Med
Assoc J 172:213–226. https://doi.org/10.1503/cmaj.1031414
Cho BHS, Xu S (2000) Effects of allyl mercaptan and various allium-derived compounds on cholesterol synthesis and secretion in Hep-G2 cells. Comp Biochem Physiol C Pharmacol Toxicol
Endocrinol. https://doi.org/10.1016/S0742-8413(00)00106-7
Choi YH, Park HS (2012) Apoptosis induction of U937 human leukemia cells by diallyl trisulfide induces through generation of reactive oxygen species. J Biomed Sci. https://doi.
org/10.1186/1423-0127-19-50
Chu Y-L, Ho C-T, Chung J-G, Raghu R, Lo Y-C, Sheen L-Y (2013) Allicin induces anti-human
liver cancer cells through the p53 gene modulating apoptosis and autophagy. J Agric Food
Chem 61(41):9839–9848
Chung LY (2006) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and
allyl disulfide. J Med Food 9:205–213. https://doi.org/10.1089/jmf.2006.9.205
Colín-González AL, Santana RA, Silva-Islas CA, Chánez-Cárdenas ME, Santamaría A,
Maldonado PD (2012) The antioxidant mechanisms underlying the aged garlic extract-and
S-allylcysteine-induced protection. Oxidative Med Cell Longev 2012:1–16. https://doi.
org/10.1155/2012/907162
de Queiroz YS, Antunes PB, Vicente SJ, Sampaio GR, Shibao J, Bastos DH, Torres EA d S (2014)
Bioactive compounds, in vitro antioxidant capacity and Maillard reaction products of raw,
boiled and fried garlic (Allium sativum L.). Int J Food Sci Technol 49(5):1308–1314
Dirsch VM, Vollmar AM (2001) Ajoene, a natural product with non-steroidal anti-inflammatory
drug (NSAID)-like properties? Biochem Pharmacol 61:587–593
DiStefano JK, Watanabe RM (2010) Pharmacogenetics of anti-diabetes drugs. Pharmaceuticals
3:2610–2646. https://doi.org/10.3390/ph3082610
Duan X, Block E, Li Z, Connelly T, Zhang J, Huang Z, Su X, Pan Y, Wu L, Chi Q, Thomas
S, Zhang S, Ma M, Matsunami H, Chen G-Q, Zhang H (2012) Crucial role of copper in detection of metal-coordinating odorants. Proc Natl Acad Sci USA 109:34923497.
Bibcode:2012PNAS.109.3492D. https://doi.org/10.1073/pnas.1111297109. PMC 3295281.
PMID 22328155
Duda G, Suliburska J, Pupek-Musialik D (2008) Effects of short-term garlic supplementation on
lipid metabolism and antioxidant status in hypertensive adults. Pharmacol Rep 60:163–170
Eftekhari Z, Bahmani M, Mohsenzadeghan A et al (2012) Evaluating the anti-leech (Limnatis
nilotica) activity of methanolic extract of Allium sativum L. compared with levamisole and
metronidazole. Comp Clin Pathol 21:1219–1222. https://doi.org/10.1007/s00580-011-1268-6
Eilat S, Oestraicher Y, Rabinkov A et al (1995) Alteration of lipid profile in hyperlipidemic rabbits
by allicin, an active constituent of garlic. Coron Artery Dis 6(12):985–990
El-Demerdash F, Yousef MI, El-Naga NA (2005) Biochemical study on the hypoglycemic effects
of onion and garlic in alloxan-induced diabetic rats. Food Chem Toxicol 43(1):57–63
Elkayam A (2003) The effects of allicin on weight in fructose-induced hyperinsulinemic, hyperlipidemic, hypertensive rats. Am J Hypertens 16:1053–1056. https://doi.org/10.1016/j.
amjhyper.2003.07.011
Fenwick GR, Hanley AB, Whitaker JR (1985a) The genus Allium—part 1. Crit Rev Food Sci Nutr
22(3):199–271
Fenwick GR, Hanley AB, Whitaker JR (1985b) The genus Allium—part 3. Crit Rev Food Sci Nutr
23(1):1–73
A. M. P. Walag et al.