383
Moon E-J, Lee YM et al (1999) A ncovel angiogenic factor derived from Aloe vera gel: β-sitosterol,
a plant sterol. Angiogenesis 3(2):117–123
Morgan M, Bone K, Mills S et al (2005) Aloe. Safety monograph. In: Mills S, Bone K (eds) The
essential guide to herbal safety. Elsevier Churchill Livingstone, St. Louis, pp 233–240
Muller SO, Eckert I, Lutz WK, Stopper H (1996) Genotoxicity of the laxative drug components
emodin, aloe-emodin and danthron in mammalian cells: topoisomerase II mediated? Mutat
Res 371:165–173
Nash RJ, Beaumont J, Veitch NC, Reynolds T, Benner J, Hughes CNG, Dring JV, Bennett RN,
Dellar JE (1992) Planta Med 58:84
Nath D, Sethi N, Singh RK, Jain AK (1992) Commonly used Indian abortifacient plants with special reference to their terratologic effects in rats. J Ethnopharmacol 36:147–154
National Toxicology Program (2001) NTP toxicology and carcinogenesis studies of emodiN (CAS
NO. 518-82-1) feed studies in F344/N rats and B6C3F1 mice. Natl Toxicol Program Tech Rep
Ser 493:1–278
National Toxicology Program (2015) Toxicology and carcinogenesis studies of a nondecolorized
whole leaf extract of Aloe vera in F344/N rats and B6C3F1 mice. http://ntp.niehs.nih.gov/ntp/
htdocs/lt_rpts/tr577_508.pdf. Accessed Oct 2015
Navarro D, Díaz-Mula HM, Guillén F, Zapata PJ, Castillo S, Serrano M, Valero D, MartínezRomero D (2011) Reduction of nectarine decay caused by rhizopus stolonifer, botrytis cinerea
and penicillium digitatum with Aloe vera gel alone or with the addition of thymol. Int J Food
Microbiol 151:241–246. https://doi.org/10.1016/j.ijfoodmicro.2011.09.009
Ndhlala A, Amoo S, Stafford G, Finnie J, Van Staden J (2009) Antimicrobial, anti-inflammatory
and mutagenic investigation of the south african tree aloe (Aloe barberae). J Ethnopharmacol
124:404–408. https://doi.org/10.1016/j.jep.2009.05.037
Negahdari S, Galehdari H, Kesmati M, Rezaie A, Shariati G (2017) Wound healing activity of
extracts and formulations of Aloe vera, Henna, Adiantum capillus-veneris, and Myrrh on mouse
dermal fibroblast cells. Int J Prev Med 8:18–18. https://doi.org/10.4103/ijpvm.IJPVM_338_16
Nejatzadeh-Barandozi F (2013) Antibacterial activities and antioxidant capacity of Aloe vera. Org
Med Chem Lett 3:5
Nejatzadeh-Barandozi F, Enferadi ST (2012) FT-IR study of the polysaccharides isolated from the
skin juice, gel juice, and flower of Aloe vera tissues affected by fertilizer treatment. Org Med
Chem Lett 2(1):33
Nesslany F, Simar-Meintieres S, Ficheux H, Marzin D (2009) Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay. Mutat Res 678:13–19
Ngo MQ, Nguyen NN, Shah SA (2010) Oral aloe vera for treatment of diabetes mellitus and
dyslipidemia. Am J Health Syst Pharm 67(21):1804–1811, 1806, 1808 passim. https://doi.
org/10.2146/ajhp100182 PMID:20966143
Ni Y, Tizard IR (2004) Analytical methodology: the gel-analysis of aloe pulp and its derivatives.
In: Reynolds T (ed) Aloes the genus Aloe. CRC Press, Boca Raton, pp 111–126
Ni Y, Turner D et al (2004) Isolation and characterization of structural components of Aloe vera L.
leaf pulp. Int Immunopharmacol 4(14):1745–1755
Niciforovic A, Adzic M, Zabric B, Radojcic MB (2007) Adjuvant antiproliferative and cytotoxic
effect of aloin in irradiated HeLaS3 cells. Biophys Chem 81:1463–1466
Noor A, Gunasekaran S, Manickam AS, Vijayalakshmi MA (2008) Antidiabetic activity of Aloe
vera and histology of organs in streptozotocin-induced diabetic rats. Curr Sci 94:1070–1076
Noor A, Gunasekaran S, Vijayalakshmi MA (2017) Improvement of insulin secretion and pancreatic β-cell function in Streptozotocin-induced diabetic rats treated with Aloe vera extract.
Pharm Res 9(Suppl 1):S99–S104. https://doi.org/10.4103/pr.pr_75_17
Okamura N, Hine N, Harada S, Fujioka T, Mihashi K, Yagi A (1996) Three chromone components
from Aloe vera leaves. Phytochemistry 43:495–498
Okamura N, Hine N, Tateyama Y, Nakazawa M, Fujioka T, Mihashi K, Yagi A (1997) Three chromone of Aloe vera leaves. Phytochemistry 45:1511–1513
18 Aloe Species as Valuable Sources of Functional Bioactives
Moon E-J, Lee YM et al (1999) A ncovel angiogenic factor derived from Aloe vera gel: β-sitosterol,
a plant sterol. Angiogenesis 3(2):117–123
Morgan M, Bone K, Mills S et al (2005) Aloe. Safety monograph. In: Mills S, Bone K (eds) The
essential guide to herbal safety. Elsevier Churchill Livingstone, St. Louis, pp 233–240
Muller SO, Eckert I, Lutz WK, Stopper H (1996) Genotoxicity of the laxative drug components
emodin, aloe-emodin and danthron in mammalian cells: topoisomerase II mediated? Mutat
Res 371:165–173
Nash RJ, Beaumont J, Veitch NC, Reynolds T, Benner J, Hughes CNG, Dring JV, Bennett RN,
Dellar JE (1992) Planta Med 58:84
Nath D, Sethi N, Singh RK, Jain AK (1992) Commonly used Indian abortifacient plants with special reference to their terratologic effects in rats. J Ethnopharmacol 36:147–154
National Toxicology Program (2001) NTP toxicology and carcinogenesis studies of emodiN (CAS
NO. 518-82-1) feed studies in F344/N rats and B6C3F1 mice. Natl Toxicol Program Tech Rep
Ser 493:1–278
National Toxicology Program (2015) Toxicology and carcinogenesis studies of a nondecolorized
whole leaf extract of Aloe vera in F344/N rats and B6C3F1 mice. http://ntp.niehs.nih.gov/ntp/
htdocs/lt_rpts/tr577_508.pdf. Accessed Oct 2015
Navarro D, Díaz-Mula HM, Guillén F, Zapata PJ, Castillo S, Serrano M, Valero D, MartínezRomero D (2011) Reduction of nectarine decay caused by rhizopus stolonifer, botrytis cinerea
and penicillium digitatum with Aloe vera gel alone or with the addition of thymol. Int J Food
Microbiol 151:241–246. https://doi.org/10.1016/j.ijfoodmicro.2011.09.009
Ndhlala A, Amoo S, Stafford G, Finnie J, Van Staden J (2009) Antimicrobial, anti-inflammatory
and mutagenic investigation of the south african tree aloe (Aloe barberae). J Ethnopharmacol
124:404–408. https://doi.org/10.1016/j.jep.2009.05.037
Negahdari S, Galehdari H, Kesmati M, Rezaie A, Shariati G (2017) Wound healing activity of
extracts and formulations of Aloe vera, Henna, Adiantum capillus-veneris, and Myrrh on mouse
dermal fibroblast cells. Int J Prev Med 8:18–18. https://doi.org/10.4103/ijpvm.IJPVM_338_16
Nejatzadeh-Barandozi F (2013) Antibacterial activities and antioxidant capacity of Aloe vera. Org
Med Chem Lett 3:5
Nejatzadeh-Barandozi F, Enferadi ST (2012) FT-IR study of the polysaccharides isolated from the
skin juice, gel juice, and flower of Aloe vera tissues affected by fertilizer treatment. Org Med
Chem Lett 2(1):33
Nesslany F, Simar-Meintieres S, Ficheux H, Marzin D (2009) Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay. Mutat Res 678:13–19
Ngo MQ, Nguyen NN, Shah SA (2010) Oral aloe vera for treatment of diabetes mellitus and
dyslipidemia. Am J Health Syst Pharm 67(21):1804–1811, 1806, 1808 passim. https://doi.
org/10.2146/ajhp100182 PMID:20966143
Ni Y, Tizard IR (2004) Analytical methodology: the gel-analysis of aloe pulp and its derivatives.
In: Reynolds T (ed) Aloes the genus Aloe. CRC Press, Boca Raton, pp 111–126
Ni Y, Turner D et al (2004) Isolation and characterization of structural components of Aloe vera L.
leaf pulp. Int Immunopharmacol 4(14):1745–1755
Niciforovic A, Adzic M, Zabric B, Radojcic MB (2007) Adjuvant antiproliferative and cytotoxic
effect of aloin in irradiated HeLaS3 cells. Biophys Chem 81:1463–1466
Noor A, Gunasekaran S, Manickam AS, Vijayalakshmi MA (2008) Antidiabetic activity of Aloe
vera and histology of organs in streptozotocin-induced diabetic rats. Curr Sci 94:1070–1076
Noor A, Gunasekaran S, Vijayalakshmi MA (2017) Improvement of insulin secretion and pancreatic β-cell function in Streptozotocin-induced diabetic rats treated with Aloe vera extract.
Pharm Res 9(Suppl 1):S99–S104. https://doi.org/10.4103/pr.pr_75_17
Okamura N, Hine N, Harada S, Fujioka T, Mihashi K, Yagi A (1996) Three chromone components
from Aloe vera leaves. Phytochemistry 43:495–498
Okamura N, Hine N, Tateyama Y, Nakazawa M, Fujioka T, Mihashi K, Yagi A (1997) Three chromone of Aloe vera leaves. Phytochemistry 45:1511–1513
18 Aloe Species as Valuable Sources of Functional Bioactives