382
Li S-W, Yang T-C, Lai C-C, Huang S-H, Liao J-M, Wan L, Lin Y-J, Lin C-W (2014) Antiviral
activity of aloe-emodin against influenza a virus via galectin-3 up-regulation. Eur J Pharmacol
738:125–132. https://doi.org/10.1016/j.ejphar.2014.05.028
Li P, Kong J, Chen Z, Huang S, Lv G, Wei B, Chu J (2019) Aloin promotes osteogenesis of bonemarrow- derived mesenchymal stem cells via the ERK1/2-dependent Runx2 signaling pathway.
J Nat Med 73(1):104–113. https://doi.org/10.1007/s11418-018-1249-z
Lim BO, Seong NS, Choue RW, Kim YD, Lee HY, Jeon TI, Park DK (2003) Efficacy of dietary
Aloe vera supplementation on hepatic cholesterol and oxidative status in aged rats. J Nutr Sci
Vitamonol 49:292–296
Lindsey KL, Jäger AK, A.M. Viljoen, B.-E. van Wyk (2002) Cyclooxygenase inhibitory activity of
Aloe species. S Afr J Bot 68(1):47–50
Liu Z, Ge X, Lu Y, Dong S, Zhao Y, Zeng M (2012) Effects of chitosan molecular weight and
degree of deacetylation on the properties of gelatine-based films. Food Hydrocoll 26:311–317.
https://doi.org/10.1016/j.foodhyd.2011.06.008
Lodovici M, Guglielmi F et al (2001) Effect of natural phenolic acids on DNA oxidation in vitro.
Food Chem Toxicol 39(12):1205–1210
Loots DT, Pieters M, Islam MS, Botes L (2011). Antidiabetic effects of Aloe ferox and Aloe greatheadii var. davyana leaf gel extracts in a low-dose streptozotocin diabetes rat model. S Afr J Sci
107(7/8)., Art. #532, 6 pages. https://doi.org/10.4102/sajs.v107i7/8.532
López A, de Tangil MS, Vega-Orellana O, Ramírez AS, Rico M (2013) Phenolic constituents,
antioxidant and preliminary antimycoplasmic activities of leaf skin and flowers of Aloe vera
(L.) Burm. f. (syn. A. Barbadensis Mill.) from the Canary islands (Spain). Molecules 18:4942–
4954. https://doi.org/10.3390/molecules18054942
Luiz C, da Rocha Neto AC, Franco PO, Di Piero RM (2017) Emulsions of essential oils and Aloe
polysaccharides: antimicrobial activity and resistance inducer potential against Xanthomonas
fragariae. Trop Plant Pathol 42:370–381
Luyckx VA, Ballantine R, Claeys M, Cuyckens F, Vanden Heuvel H, Cimanga RK, Vlietinck AJ,
DeBroe ME, Katz IJ (2002) Herbal remedy-associated acute renal failure secondary to Cape
aloes. Am J Kidney Dis 39:E13
Madhyastha R, Madhyastha H, Pengjam Y, Nurrahmah QI, Nakajima Y, Maruyama M (2019) The
pivotal role of microRNA-21 in osteoclastogenesis inhibition by anthracycline glycoside aloin.
J Nat Med. https://doi.org/10.1007/s11418-018-1237-3
Mahendiran D, Subash G, Arumai Selvan D, Dilaveez R, Senthil Kumar R, Kalilur Rahiman
A (2017) Biosynthesis of zinc oxide nanoparticles using plant extracts of Aloe vera and
Hibiscus sabdariffa: phytochemical, antibacterial, antioxidant and anti-proliferative studies.
BioNanoScience 7(3):530–545. https://doi.org/10.1007/s12668-017-0418-y
Mandal G, Das A (1980) Structure of the D-galactan isolated from Aloe barbadensis Miller.
Carbohydr Res 86(2):247–257
Manitto P, Monti D, Speranza G (1990) Gazz Chim Ital 120:641
Martikainen JA, Ottelin A-M et al (2007) Plant stanol esters are potentially cost-effective in the
prevention of coronary heart disease in men: Bayesian modelling approach. Eur J Cardiovasc
Prev Rehabil 14(2):265–272
Masaldan S, Iyer VV (2014) Exploration of effects of emodin in selected cancer cell lines:
enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxialike conditions. J Appl Toxicol 34(1):95–104
Mbithi CM, Matu EN, Maina NWN (2018) Phytochemical screening, antioxidant activity and
hypoglycemic potential of Kenyan Aloe lateritia and Aloe secundiflora extracts in AlloxanInduced diabetic Swiss Albino Mice. Eur J Med Plant 24:1–18
Misawa E, Tanaka M, Nomaguchi K, Nabeshima K, Yamada M, Toida T, Iwatsuki K (2012)
Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity- associated metabolic disorders in zucker diabetic fatty rats. J Agric Food Chem
60:2799–2806. https://doi.org/10.1021/jf204465j. [PubMed] [CrossRef] [Google Scholar]
Mody N, Parhami F, Sarafian TA, Demer LL (2001) Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 31:509–519. https://doi.org/10.1016/
S0891-5849(01)00610-4
C. Egbuna et al.
Li S-W, Yang T-C, Lai C-C, Huang S-H, Liao J-M, Wan L, Lin Y-J, Lin C-W (2014) Antiviral
activity of aloe-emodin against influenza a virus via galectin-3 up-regulation. Eur J Pharmacol
738:125–132. https://doi.org/10.1016/j.ejphar.2014.05.028
Li P, Kong J, Chen Z, Huang S, Lv G, Wei B, Chu J (2019) Aloin promotes osteogenesis of bonemarrow- derived mesenchymal stem cells via the ERK1/2-dependent Runx2 signaling pathway.
J Nat Med 73(1):104–113. https://doi.org/10.1007/s11418-018-1249-z
Lim BO, Seong NS, Choue RW, Kim YD, Lee HY, Jeon TI, Park DK (2003) Efficacy of dietary
Aloe vera supplementation on hepatic cholesterol and oxidative status in aged rats. J Nutr Sci
Vitamonol 49:292–296
Lindsey KL, Jäger AK, A.M. Viljoen, B.-E. van Wyk (2002) Cyclooxygenase inhibitory activity of
Aloe species. S Afr J Bot 68(1):47–50
Liu Z, Ge X, Lu Y, Dong S, Zhao Y, Zeng M (2012) Effects of chitosan molecular weight and
degree of deacetylation on the properties of gelatine-based films. Food Hydrocoll 26:311–317.
https://doi.org/10.1016/j.foodhyd.2011.06.008
Lodovici M, Guglielmi F et al (2001) Effect of natural phenolic acids on DNA oxidation in vitro.
Food Chem Toxicol 39(12):1205–1210
Loots DT, Pieters M, Islam MS, Botes L (2011). Antidiabetic effects of Aloe ferox and Aloe greatheadii var. davyana leaf gel extracts in a low-dose streptozotocin diabetes rat model. S Afr J Sci
107(7/8)., Art. #532, 6 pages. https://doi.org/10.4102/sajs.v107i7/8.532
López A, de Tangil MS, Vega-Orellana O, Ramírez AS, Rico M (2013) Phenolic constituents,
antioxidant and preliminary antimycoplasmic activities of leaf skin and flowers of Aloe vera
(L.) Burm. f. (syn. A. Barbadensis Mill.) from the Canary islands (Spain). Molecules 18:4942–
4954. https://doi.org/10.3390/molecules18054942
Luiz C, da Rocha Neto AC, Franco PO, Di Piero RM (2017) Emulsions of essential oils and Aloe
polysaccharides: antimicrobial activity and resistance inducer potential against Xanthomonas
fragariae. Trop Plant Pathol 42:370–381
Luyckx VA, Ballantine R, Claeys M, Cuyckens F, Vanden Heuvel H, Cimanga RK, Vlietinck AJ,
DeBroe ME, Katz IJ (2002) Herbal remedy-associated acute renal failure secondary to Cape
aloes. Am J Kidney Dis 39:E13
Madhyastha R, Madhyastha H, Pengjam Y, Nurrahmah QI, Nakajima Y, Maruyama M (2019) The
pivotal role of microRNA-21 in osteoclastogenesis inhibition by anthracycline glycoside aloin.
J Nat Med. https://doi.org/10.1007/s11418-018-1237-3
Mahendiran D, Subash G, Arumai Selvan D, Dilaveez R, Senthil Kumar R, Kalilur Rahiman
A (2017) Biosynthesis of zinc oxide nanoparticles using plant extracts of Aloe vera and
Hibiscus sabdariffa: phytochemical, antibacterial, antioxidant and anti-proliferative studies.
BioNanoScience 7(3):530–545. https://doi.org/10.1007/s12668-017-0418-y
Mandal G, Das A (1980) Structure of the D-galactan isolated from Aloe barbadensis Miller.
Carbohydr Res 86(2):247–257
Manitto P, Monti D, Speranza G (1990) Gazz Chim Ital 120:641
Martikainen JA, Ottelin A-M et al (2007) Plant stanol esters are potentially cost-effective in the
prevention of coronary heart disease in men: Bayesian modelling approach. Eur J Cardiovasc
Prev Rehabil 14(2):265–272
Masaldan S, Iyer VV (2014) Exploration of effects of emodin in selected cancer cell lines:
enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxialike conditions. J Appl Toxicol 34(1):95–104
Mbithi CM, Matu EN, Maina NWN (2018) Phytochemical screening, antioxidant activity and
hypoglycemic potential of Kenyan Aloe lateritia and Aloe secundiflora extracts in AlloxanInduced diabetic Swiss Albino Mice. Eur J Med Plant 24:1–18
Misawa E, Tanaka M, Nomaguchi K, Nabeshima K, Yamada M, Toida T, Iwatsuki K (2012)
Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity- associated metabolic disorders in zucker diabetic fatty rats. J Agric Food Chem
60:2799–2806. https://doi.org/10.1021/jf204465j. [PubMed] [CrossRef] [Google Scholar]
Mody N, Parhami F, Sarafian TA, Demer LL (2001) Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 31:509–519. https://doi.org/10.1016/
S0891-5849(01)00610-4
C. Egbuna et al.
