365
18.5.10 Antihyperlipidemic Activity
Recent studies show the antihyperlipidemic activity of A. vera and its positive effect
in the prevention of fatty streak and development of atherosclerosis. Due to less
insulin secretion or its action in the body, the increase in circulatory glucose levels
is responsible for an increase in the free fatty acids (FFA’s) by the action of hormone
sensitive lipase from adipose tissue in the blood. The excess FFAs in circulation
enter into the liver for the synthesis of Tri glycerides (TG) and further lipoprotein
biosynthesis. Liver plays a vital role in glucose and lipid metabolism. In diabetes,
its function is affected and results in liver steatosis (accumulation of lipids) (Seifter
and England 1982). The supplementation of ethanolic extract of Aloe vera leaf gel
(300 mg/kg body weight) in diabetic rats showed an increase in the plasma insulin
levels from remnant or regenerated pancreatic β-cells, whereas blood glucose levels
were brought to normal. In addition, Aloe vera extract administration also showed a
decrease in the plasma lipids, liver cholesterol, and kidney TG levels (Rajasekaran
et al. 2006). Authors concluded that, phenolic and saponin compounds present in
the Aloe vera extract might be responsible for hypoglycemic and hypolipidemic
effects.
In a randomized double-blind placebo-controlled clinical trial, efficacy of A. vera
leaf gel was checked in hyperlipidemic type 2 diabetic patients, results showed the
reduction in low-density lipoprotein (LDL) and total cholesterol levels (Huseini
et al. 2012). In Zucker diabetic fatty rats administration of phytosterols isolated
from gel of A.vera improve hyperglycemia and reduce visceral fat mass (Dana et al.
2012). Medicinal herbs like Aloe barbadensis Mill. or A. vera has shown to possess
anti-hyperlipidemic and hypoglycaemic potential. Letrozole-induced polycystic
ovarian syndrome rat model treated with A. vera gel shows increase in HDL cholesterol along with reduction in LDL and triglyceride levels. The phytoconstituents
present in A. vera gel manage metabolic complications by improving lipid metabolizing enzyme activities, abnormal estrous cyclicity and glucose intolerance (Desai
et al. 2012). A remarkable antihyperlipidemic effect was shown by a dried pulp
extracted from leaf of A. succotrina in high-fat diet and fructose-induced hyperlipidemic Wistar albino rats. A. succotrina normalize serum lipid profile and ameliorate oxidative stress in liver without affecting relative heart weight (Dhingra et al.
2014). The selenium (Se) polysaccharide (Se-AVP) from A. vera was shown to have
cardioprotective effect against myocardial I/R injured in rats, it was noted that
(Se-AVP) act as endogenous antioxidant which protect rat hearts from oxidative
stress-induced myocardial apoptosis (Yang et al. 2017).
The antioxidative and hypocholestrol effects of Aloe vera was assessed in randomly selected liver of male specific pathogen-free (SPF) Fischer 344 rats to 17 of
four groups: Group A (control) was fed test chow without aloe supplementation;
Group B was fed a diet containing a 1% (per weight basis) freeze-dried aloe filet;
Group C was fed a diet containing a 1% (per weight basis) charcoal-processed,
18 Aloe Species as Valuable Sources of Functional Bioactives
18.5.10 Antihyperlipidemic Activity
Recent studies show the antihyperlipidemic activity of A. vera and its positive effect
in the prevention of fatty streak and development of atherosclerosis. Due to less
insulin secretion or its action in the body, the increase in circulatory glucose levels
is responsible for an increase in the free fatty acids (FFA’s) by the action of hormone
sensitive lipase from adipose tissue in the blood. The excess FFAs in circulation
enter into the liver for the synthesis of Tri glycerides (TG) and further lipoprotein
biosynthesis. Liver plays a vital role in glucose and lipid metabolism. In diabetes,
its function is affected and results in liver steatosis (accumulation of lipids) (Seifter
and England 1982). The supplementation of ethanolic extract of Aloe vera leaf gel
(300 mg/kg body weight) in diabetic rats showed an increase in the plasma insulin
levels from remnant or regenerated pancreatic β-cells, whereas blood glucose levels
were brought to normal. In addition, Aloe vera extract administration also showed a
decrease in the plasma lipids, liver cholesterol, and kidney TG levels (Rajasekaran
et al. 2006). Authors concluded that, phenolic and saponin compounds present in
the Aloe vera extract might be responsible for hypoglycemic and hypolipidemic
effects.
In a randomized double-blind placebo-controlled clinical trial, efficacy of A. vera
leaf gel was checked in hyperlipidemic type 2 diabetic patients, results showed the
reduction in low-density lipoprotein (LDL) and total cholesterol levels (Huseini
et al. 2012). In Zucker diabetic fatty rats administration of phytosterols isolated
from gel of A.vera improve hyperglycemia and reduce visceral fat mass (Dana et al.
2012). Medicinal herbs like Aloe barbadensis Mill. or A. vera has shown to possess
anti-hyperlipidemic and hypoglycaemic potential. Letrozole-induced polycystic
ovarian syndrome rat model treated with A. vera gel shows increase in HDL cholesterol along with reduction in LDL and triglyceride levels. The phytoconstituents
present in A. vera gel manage metabolic complications by improving lipid metabolizing enzyme activities, abnormal estrous cyclicity and glucose intolerance (Desai
et al. 2012). A remarkable antihyperlipidemic effect was shown by a dried pulp
extracted from leaf of A. succotrina in high-fat diet and fructose-induced hyperlipidemic Wistar albino rats. A. succotrina normalize serum lipid profile and ameliorate oxidative stress in liver without affecting relative heart weight (Dhingra et al.
2014). The selenium (Se) polysaccharide (Se-AVP) from A. vera was shown to have
cardioprotective effect against myocardial I/R injured in rats, it was noted that
(Se-AVP) act as endogenous antioxidant which protect rat hearts from oxidative
stress-induced myocardial apoptosis (Yang et al. 2017).
The antioxidative and hypocholestrol effects of Aloe vera was assessed in randomly selected liver of male specific pathogen-free (SPF) Fischer 344 rats to 17 of
four groups: Group A (control) was fed test chow without aloe supplementation;
Group B was fed a diet containing a 1% (per weight basis) freeze-dried aloe filet;
Group C was fed a diet containing a 1% (per weight basis) charcoal-processed,
18 Aloe Species as Valuable Sources of Functional Bioactives