366
freeze-dried aloe filet; and group D was fed a diet containing a charcoal processed
freeze-dried, whole leaf aloe (0.02% per weight basis) in the drinking water. Results
show that a life-long intake of aloe had superior anti-oxidative action against lipid
peroxidation in vivo, as indicated by reduced levels of hepatic phosphatidyl choline
hydroperoxide. Additional anti-oxidative action was evidenced by enhanced superoxide dismutase (SOD) and catalase activity in groups B and C. furthermore, study
revealed that hepatic cholesterol significantly increased in the control group in contest to the aloe-supplemented groups, which showed approximately 30% lower cholesterol levels, thereby an effective hypocholestermic efficacy (Lim et al. 2003). The
effect on man triglyceride level was estimated which is due to inhibition of the
hepatic production of chylomicron (Boban et al. 2006). Saponin and phenolic components of Aloe vera extract also exerted the antihyperlipidemic effect by decreasing the levels of total cholesterol, triglyceride and lipoprotein. High blood cholesterol
is a major risk factor for heart disease and stroke.
A study was conducted on the effect of Aloe vera extract on the serum cholesterol level on male Calote sversicolor Daudin. The calotes versicolor Daudin were
made hypercholesterolemic by oral administration of cholesterol (100 mg/kg body
weight/day) suspended in ground nut oil using dropper. In 1 month cholesterol feeding experiment, the serum cholesterol level in normal controls (not given cholesterol) was 321.333 ± 16.621 mg/dl and in cholesterol fed animals 437.333 ± 8.066 mg/
dl. To such animals when different doses of raw extracts of Aloe vera leaves were
given along with cholesterol, there was significant decrease in serum cholesterol
level. Four groups of Calotes were administered Aloe vera (L) extract in four different doses (3 mg/kg, 4 mg/kg, 5 mg/kg and 6 mg/kg/day) for 21 days. There was a
significant increase in serum cholesterol levels at 1% level after feeding with high
cholesterol diet. There was a significant decrease in serum cholesterol levels in all
the Aloe vera (L) treated groups. Significance level is 5% for a dose of 6 mg/kg and
other doses i.e. of 3 mg/kg, of 4 mg/kg and of 5 mg/kg show significant decrease at
0.1%, 0.5% and 0.2% level, respectively (Chandrakar et al. 2008).
18.5.11 Antiaging Effects of Aloes
Photochemoprotection has recently become valuable way to prevent aging. Although
there are many active synthetic antiaging drugs that have been used for years, these
drugs may exert safety risk on human health. Therefore, present era of treating an
aged skin has been diverted towards natural biomaterials (Rajashree and Rose
2018). The plant Aloe has also been studied to protect the skin again UV rays
(Surjushe et al. 2008).
Aloe vera gel was reported to improve skin hydration and to possess moisturizing
effect for stratum corneum at different tested concentrations (0.1%, 0.25%, and
0.5%) (Chandan et al. 2007). Mucopolysaccharides (MPS) present in Aloe gel is
responsible for the water-holding capacity exerted by the gel to the skin. Aloe vera
can improve the elasticity of the skin through activation of the fibroblasts which
C. Egbuna et al.
freeze-dried aloe filet; and group D was fed a diet containing a charcoal processed
freeze-dried, whole leaf aloe (0.02% per weight basis) in the drinking water. Results
show that a life-long intake of aloe had superior anti-oxidative action against lipid
peroxidation in vivo, as indicated by reduced levels of hepatic phosphatidyl choline
hydroperoxide. Additional anti-oxidative action was evidenced by enhanced superoxide dismutase (SOD) and catalase activity in groups B and C. furthermore, study
revealed that hepatic cholesterol significantly increased in the control group in contest to the aloe-supplemented groups, which showed approximately 30% lower cholesterol levels, thereby an effective hypocholestermic efficacy (Lim et al. 2003). The
effect on man triglyceride level was estimated which is due to inhibition of the
hepatic production of chylomicron (Boban et al. 2006). Saponin and phenolic components of Aloe vera extract also exerted the antihyperlipidemic effect by decreasing the levels of total cholesterol, triglyceride and lipoprotein. High blood cholesterol
is a major risk factor for heart disease and stroke.
A study was conducted on the effect of Aloe vera extract on the serum cholesterol level on male Calote sversicolor Daudin. The calotes versicolor Daudin were
made hypercholesterolemic by oral administration of cholesterol (100 mg/kg body
weight/day) suspended in ground nut oil using dropper. In 1 month cholesterol feeding experiment, the serum cholesterol level in normal controls (not given cholesterol) was 321.333 ± 16.621 mg/dl and in cholesterol fed animals 437.333 ± 8.066 mg/
dl. To such animals when different doses of raw extracts of Aloe vera leaves were
given along with cholesterol, there was significant decrease in serum cholesterol
level. Four groups of Calotes were administered Aloe vera (L) extract in four different doses (3 mg/kg, 4 mg/kg, 5 mg/kg and 6 mg/kg/day) for 21 days. There was a
significant increase in serum cholesterol levels at 1% level after feeding with high
cholesterol diet. There was a significant decrease in serum cholesterol levels in all
the Aloe vera (L) treated groups. Significance level is 5% for a dose of 6 mg/kg and
other doses i.e. of 3 mg/kg, of 4 mg/kg and of 5 mg/kg show significant decrease at
0.1%, 0.5% and 0.2% level, respectively (Chandrakar et al. 2008).
18.5.11 Antiaging Effects of Aloes
Photochemoprotection has recently become valuable way to prevent aging. Although
there are many active synthetic antiaging drugs that have been used for years, these
drugs may exert safety risk on human health. Therefore, present era of treating an
aged skin has been diverted towards natural biomaterials (Rajashree and Rose
2018). The plant Aloe has also been studied to protect the skin again UV rays
(Surjushe et al. 2008).
Aloe vera gel was reported to improve skin hydration and to possess moisturizing
effect for stratum corneum at different tested concentrations (0.1%, 0.25%, and
0.5%) (Chandan et al. 2007). Mucopolysaccharides (MPS) present in Aloe gel is
responsible for the water-holding capacity exerted by the gel to the skin. Aloe vera
can improve the elasticity of the skin through activation of the fibroblasts which
C. Egbuna et al.