Shear-Enhanced Filtration
(SEF) for the Separation and Concentration
of Protein
Wenxiang Zhang, Luhui Ding, and Nabil Grimi
Abstract
In this communication, we reviewed the shear-enhanced
filtration (SEF) for the separation and concentration of
protein. Firstly, the configuration, operation parameter, and
anti-fouling capacity for different SEF modules, including
rotating disk/rotor, rotating membrane, and vibratory
systems, were summarized. Then, two SEF application
cases (milk solution filtration and Luzerne juice filtration)
were introduced. For milk solution, milk proteins were
separated and concentrated. The effects of hydraulic
conditions of SEF on filtration performance were investigated by response surface methodology for process
parameter optimization. Pore-blocking model was utilized
for better understanding the membrane fouling mechanism.
Afterwards, the retentate with high milk proteins was
successfully applied for cheese production. After filtration,
the membrane cleaning process was also conducted by
shear effect to improve the efficiency. The other aspect,
during the Luzerne juice filtration process, leaf proteins
were separated and concentrated. At first, the influence of
filtration module structures on filtration performance was
studied. Secondly, a stepwise multisite Darcy’s law model
(SMDM) was proposed to simulate the complex fouling
process and calculate the key fouling parameters. At last,
the operation conditions were optimized to enhance the
filtration efficiency (permeate flux and filtration time) and
separation performance (the protein rejection and protein
purity in retentate). This work can give a valuable
information for the application of SEF for the separation
and concentration of protein solution.
Keywords
Shear-enhanced filtration (SEF) Á Membrane fouling
mechanism Á Hydraulic condition optimization Á
Separation and concentration of protein Á Membrane
cleaning
1 Introduction
As a considerably effective, flexible (greater flexibility in
design and scale-up) and economical process (energy saving
and no additives and chemicals required), membrane filtration has been considered as an environmentally friendly
separation technique. It has been used in many chemical
processes, including purification, clarification, concentration
dewatering, and so on. According to pore size, it is classified
as microfiltration (MF), ultrafiltration (UF), nanofiltration
(NF), and reverse osmosis (RO). Based on the configurations
of filtration modules and operating conditions, membrane
filtration has two conventional configurations: dead-end filtration (DF) and cross-flow filtration (CF). During membrane filtration process, flux decline caused by membrane
fouling and concentration polarization would increase
feeding flowrate and mean transmembrane pressure (TMP),
then enhancing energy cost and bringing about non-optimal
membrane utilization. Shear-enhanced filtration (SEF) can
impose high shear rates and perturb the concentration
polarization layer on membrane surface for alleviating the
membrane fouling, afterwards decreasing filtration resistance
and flux decline. Thus, compared with conventional modules, SEF module does not only improve substantially the
permeate flux without a much larger inlet flow rate, but also
straightening membrane selectivity (Zhang et al. 2015; Jaffrin 2008; Ding et al. 2015).
W. Zhang (&)
College of Water Conservancy and Civil Engineering,
South China Agricultural University, Guangzhou, China
e-mail: Zhangwenxiang6@hotmail.com
Department of Civil and Environmental Engineering, Faculty
of Science and Technology, University of Macau, Macau, China
L. Ding Á N. Grimi
ESCOM, EA 4297 TIMR, Centre de Recherch Royallieu,
Sorbonne University, Université de Technologire de Compiègne,
CS 60319, 60203 Compiègne Cedex, France
© Springer Nature Switzerland AG 2021
Z. Zhang et al. (eds.), Membrane Technology Enhancement for Environmental Protection
and Sustainable Industrial Growth, Advances in Science, Technology & Innovation,
https://doi.org/10.1007/978-3-030-41295-1_9
127
(SEF) for the Separation and Concentration
of Protein
Wenxiang Zhang, Luhui Ding, and Nabil Grimi
Abstract
In this communication, we reviewed the shear-enhanced
filtration (SEF) for the separation and concentration of
protein. Firstly, the configuration, operation parameter, and
anti-fouling capacity for different SEF modules, including
rotating disk/rotor, rotating membrane, and vibratory
systems, were summarized. Then, two SEF application
cases (milk solution filtration and Luzerne juice filtration)
were introduced. For milk solution, milk proteins were
separated and concentrated. The effects of hydraulic
conditions of SEF on filtration performance were investigated by response surface methodology for process
parameter optimization. Pore-blocking model was utilized
for better understanding the membrane fouling mechanism.
Afterwards, the retentate with high milk proteins was
successfully applied for cheese production. After filtration,
the membrane cleaning process was also conducted by
shear effect to improve the efficiency. The other aspect,
during the Luzerne juice filtration process, leaf proteins
were separated and concentrated. At first, the influence of
filtration module structures on filtration performance was
studied. Secondly, a stepwise multisite Darcy’s law model
(SMDM) was proposed to simulate the complex fouling
process and calculate the key fouling parameters. At last,
the operation conditions were optimized to enhance the
filtration efficiency (permeate flux and filtration time) and
separation performance (the protein rejection and protein
purity in retentate). This work can give a valuable
information for the application of SEF for the separation
and concentration of protein solution.
Keywords
Shear-enhanced filtration (SEF) Á Membrane fouling
mechanism Á Hydraulic condition optimization Á
Separation and concentration of protein Á Membrane
cleaning
1 Introduction
As a considerably effective, flexible (greater flexibility in
design and scale-up) and economical process (energy saving
and no additives and chemicals required), membrane filtration has been considered as an environmentally friendly
separation technique. It has been used in many chemical
processes, including purification, clarification, concentration
dewatering, and so on. According to pore size, it is classified
as microfiltration (MF), ultrafiltration (UF), nanofiltration
(NF), and reverse osmosis (RO). Based on the configurations
of filtration modules and operating conditions, membrane
filtration has two conventional configurations: dead-end filtration (DF) and cross-flow filtration (CF). During membrane filtration process, flux decline caused by membrane
fouling and concentration polarization would increase
feeding flowrate and mean transmembrane pressure (TMP),
then enhancing energy cost and bringing about non-optimal
membrane utilization. Shear-enhanced filtration (SEF) can
impose high shear rates and perturb the concentration
polarization layer on membrane surface for alleviating the
membrane fouling, afterwards decreasing filtration resistance
and flux decline. Thus, compared with conventional modules, SEF module does not only improve substantially the
permeate flux without a much larger inlet flow rate, but also
straightening membrane selectivity (Zhang et al. 2015; Jaffrin 2008; Ding et al. 2015).
W. Zhang (&)
College of Water Conservancy and Civil Engineering,
South China Agricultural University, Guangzhou, China
e-mail: Zhangwenxiang6@hotmail.com
Department of Civil and Environmental Engineering, Faculty
of Science and Technology, University of Macau, Macau, China
L. Ding Á N. Grimi
ESCOM, EA 4297 TIMR, Centre de Recherch Royallieu,
Sorbonne University, Université de Technologire de Compiègne,
CS 60319, 60203 Compiègne Cedex, France
© Springer Nature Switzerland AG 2021
Z. Zhang et al. (eds.), Membrane Technology Enhancement for Environmental Protection
and Sustainable Industrial Growth, Advances in Science, Technology & Innovation,
https://doi.org/10.1007/978-3-030-41295-1_9
127