Ar-X
Pd NPs
0.2 mol %
NaOAc
TBAB, DMSO 120
o
C
Ar
X = Br, Cl
Ar-X
OBu
O
Pd NPs
0.1 mol %
NaOAc
TBAB,
DMSO, 130
o
C
OBu
O
Ar
F
F
N
H
2 N
S
N
74% (45 h)
31% (45 h)
73% (45 h)
98% (42 h)
81% (45 h)
O
OBu
O
OBu
O
OBu
O
OBu
O
OBu
O
O
2 N
F
O
85% (23 h)
57% (30 h)
72% (26 h)
82% (23 h)
S
82% (18 h)
Fig. 11
Ligand and copper-free Pd NP-catalyzed Sonogashira and Heck cross-couplings
88
M. Cortes-Clerget et al.