4 Experimental Data
39
2.1h N-(4-Methoxyphenyl)-4-methyl-N-(1-oxo-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)benzenesulfonamide
The product was prepared according to general procedure C. Purification by column chromatography on silica gel (EtOAc:heptane = 1:2) yielded the product
(70.4 mg, 72%) as a pale yellow solid.
1
H NMR (400 MHz, CDCl3): δ = 7.40 (d, J = 8.3 Hz, 2H
24,28
), 7.31–7.16 (m,
7H
Ar
), 7.13–7.08 (m, 2H
Ar
), 6.77 (d, J = 9.0 Hz, 2H
5,12
), 5.03 (dd, J = 8.1, 6.4 Hz,
1H
1
), 3.93–3.85 (m, 1H
6
), 3.78 (s, 3H
22
), 3.45–3.28 (m, 3H
6,9
), 2.64–2.48 (m,
2H
13
), 2.39 (s, 3H
29
), 2.07–1.82 (m, 6H
Alk
) ppm;
13
C NMR (100 MHz, CDCl3): δ
= 167.9 (C
2
), 159.7 (C
Ar
), 143.4 (C
Ar
), 141.0 (C
Ar
), 137.0 (C
Ar
), 133.5 (2CH
Ar
),
129.2 (2CH
Ar
), 128.6 (2CH
Ar
), 128.6 (2CH
Ar
), 128.2 (C
Ar
), 127.9 (2CH
Ar
), 126.3
(CH
17
), 113.9 (2CH
Ar
), 59.0 (CH3
22
), 55.4 (CH
1
), 46.4 (CH2
6
), 46.2 (CH2
9
), 32.5
(CH2
Alk
), 32.4 (CH2
Alk
), 26.5 (CH2
Alk
), 24.3 (CH2
Alk
), 21.6 (CH3
29
) ppm; IR (neat):
= 3062, 3026, 2952, 2874, 2240, 1644, 1602, 1505, 1439, 1341, 1249, 1158,
914, 727, 589 cm
-1
; HRMS (ESI): m/z calculated for [M+H]
+
(C28H33N2O4S)
493.2156, found 493.2164.