38
4 Experimental Data
2.1g 4-Methyl-N-(1-oxo-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)-N-phenylbenzenesulfonamide
The product was prepared according to general procedure C. Purification by column chromatography on silica gel (EtOAc:heptane = 1:3) yielded the product
(69.7 mg, 75%) as a white solid.
1
H NMR (400 MHz, CDCl3): δ = 7.36 (d, J = 8.6 Hz, 2H
Ar
), 7.32–7.19 (m,
7H
Ar
), 7.18–7.10 (m, 3H
Ar
), 7.98–7.93 (m, 2H
Ar
), 5.04–4.96 (m, 1H
1
), 3.88–3.78
(m, 1H
6
), 3.40–3.22 (m, 3H
6,9
), 2.59–2.42 (m, 2H
13
), 2.34 (s, 3H
29
), 2.03–1.64 (m,
6H
Alk
) ppm;
13
C NMR (100 MHz, CDCl3): δ = 167.8 (C
2
), 143.5 (C
Ar
), 140.9
(C
Ar
), 137.0 (C
Ar
), 136.0 (C
Ar
), 132.4 (2CH
Ar
), 129.3 (2CH
Ar
), 128.8 (CH
10
), 128.7
(2CH
Ar
), 128.7 (2CH
Ar
), 128.6 (2CH
Ar
), 127.9 (2CH
Ar
), 126.4 (CH
17
), 59.1 (CH
1
),
46.4 (CH2
6
), 46.3 (CH2
9
), 32.6 (CH2
Alk
), 32.4 (CH2
Alk
), 26.5 (CH2
Alk
), 24.3
(CH2
Alk
), 21.7 (CH3
29
) ppm; IR (neat):
= 3061, 3026, 2951, 2874, 2242, 1643,
1597, 1491, 1439, 1342, 1159, 909, 729, 697, 657 cm
-1
; HRMS (ESI): m/z calculated for [M+H]
+
(C27H31N2O3S) 463.2050, found 463.2046.