4.3 Materials Chemistry
137
Si
NH 2
N
N
NAr
N
O
Cl
Et 3 N, DCM
rt, 1 h
H2O
30
o C, 0.5 h
MeOEGMA
CuCl, CuBr2, Bipy
NH 2
NH 2
NH 2
NH
O
N
N
ArN
N
NH 2
Polydopamine
Si
Polydopamine
NH 2
NH
O
N
N
ArN
N
NH2
NH
O
ArN
N
Si
Polydopamine
NH2
NH
O
N
N
ArN
N
N
O
O
Br
O
O
NH2
NH
O
ArN
N
Si
Polydopamine
NH2
NH
O
N
N
ArN
N
N
O
O
N
O
O
O
O
Br
h, DCM
rt, 1 h
NH 2
NH
O
N
N
ArN
N
Si
Polydopamine
NH 2
NH
O
N
N
ArN
N
=
Cl
O
O
O
O
O
n
m
Scheme 4.44 The photo-patterning of a surface through the application of NI cycloaddition and a
shadow-mask
immobilisation of a 21-sequence peptide onto a surface, once again employing NI
1,3-dipolar cycloaddition chemistry [144].
While all of the examples discussed up until this point involve the application of
silicon as the heterogenous layer, alternatives are well documented. Cellulose is an
extremely common substrate, and is typically modified via esterification or alkylation
with the NI precursor. One such report from 2014 exemplifies the augmentation
of cellulose with both a polyacrylamide species and the protein streptavidin, both