Table 6
(continued)
Reference
and study
Location
Design
Study dates
Population sample
size
Exposure assessment
Pesticides/
metabolites
Outcomes of interest
Main pyrethroid
findings
[60]
Mexico
(ELEMENT
cohort)
1997–2001
during the third trimester of pregnancy
(BSID-IIS using
mental and psychomotor developmental
index
– MDI and
PDI) at 24 and
36 months of age
(assessments by
research personnel)
scores
At 24 months, lower
MDI among participants in the median
and high 3-PBA
level categories
compared to those
with no detectable
3-PBA (only marginally significant, p
for trend
¼ 0.07),
slightly stronger in
girls
Viel et al.,
2015
[61]
France
Subset of the longitudinal motherchild cohort study
(PELAGIE cohort)
2002–2006
287 mother-child
pairs
Urine sample collected from the
mothers during early
pregnancy (6–
19 weeks) (205 samples) and
from the
infant at 6 years of
age (282 samples)
Metabolites of pyrethroids (3-PBA, cisand trans-DCCA, cisDBCA)
(6–9% 4-F-3PBA
> LOD,
detected vs not
detected for this
analysis)
Cognitive development at 6 years of age
(using verbal comprehension and working memory index
from WISC-IV)
(assessments by
psychologist)
No association
between prenatal
metabolite levels and
any children’s cognitive scores
Negative association
between childhood
3-PBA and cisDBCA levels and
verbal and working
memory scores
No association with
childhood
DCCA
(cis and trans)
and
4-F-3-PBA levels
288
A.-M. Saillenfait and S. Malard